False item recognition in patients with Alzheimer's disease

Abe, Nobuhito; Fujii, Toshikatsu; Nishio, Yoshiyuki; Iizuka, Osamu; Kanno, Shigenori; Kikuchi, Hiroe; Takagi, Masahito; Hiraoka, Kotaro; Yamasaki, Hiroshi; Choi, Hyunjoo; Hirayama, Kazumi; Shinohara, Mayumi; Mori, Etsuro

doi:10.1016/j.neuropsychologia.2011.03.015

Cited by 35 publications

(39 citation statements)

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“…For example, it has been shown that patients with Alzheimer's disease, compared with healthy controls, show difficulty using recollection (i.e., the mental reinstatement of experienced events during which unique details of memory are recalled) to counteract false recognition (e.g., Budson, Daffner, Desikan, & Schacter, 2000;Gallo, Sullivan, Daffner, Schacter, & Budson, 2004;Abe et al, 2011;Hanaki et al, 2011). These findings lead to the conclusion that the memory distortions observed in the patients are caused by cognitive deficits due to damage to specific brain areas.…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging Studies of False Memory: A Selective Review

Abe

2012

PSYCHOLOGIA -An International Journal of Psychological Sciences

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It is widely recognized that human memory is an imperfect process that sometimes causes various kinds of distortions and illusions. Recently, some light has been shed on the brain mechanisms involved in this false memory phenomenon as a result of research into its neural basis embarked on by cognitive neuroscientists. This article reviews neuroimaging studies that have attempted to distinguish between true and false memory retrieval. It also reviews neuroimaging studies that have measured neural activity during encoding and addresses the question of whether the encodingrelated neural activity predicts subsequent memory distortions. Finally, there is a brief discussion from the cognitive neuroscience perspective about whether the memory distortion reflects deficient cognitive processing or is a by-product of adaptive cognitive processing.Key words: false memory, fMRI, PET, recognition, recollection.Memory problems are mainly characterized by the failure to retrieve desired information, but sometimes people have memories of events that did not occur. Studies of this false memory phenomenon have a long history in the field of psychology, and it is now broadly accepted that human memory is prone to various kinds of distortions and illusions (Roediger, 1996;Schacter, 1999;Loftus, 2003). Memory distortions, as well as normal forgetting, provide valuable opportunities for researchers to analyze scientifically memory processing, which would be extremely difficult if memory were perfect.The development of neuroimaging techniques during the past two decades -positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) -has enabled us directly to measure brain activity associated with various cognitive functions. Many researchers in cognitive neuroscience have used functional neuroimaging to delineate the neural correlates of memory distortion and have attempted to distinguish true and false memories. The present paper reviews current progress in the study of the neural basis of false memory. This paper consists of three main sections. The first section discusses attempts to use PET and fMRI to distinguish retrieval processes between true and false memories. The second section discusses attempts to measure brain activity during encoding processes and to determine whether encoding-related brain activity predicts subsequent memory distortions. The concluding section of this paper briefly discusses from the cognitive neuroscience perspective whether memory distortion reflects deficient cognitive processing or is a by-product of adaptive cognitive processing.

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Section: Discussionmentioning

confidence: 99%

Neuroimaging Studies of False Memory: A Selective Review

Abe

2012

PSYCHOLOGIA -An International Journal of Psychological Sciences

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“…Therefore, to control for response bias, we will calculate the corrected false recognition rates by subtracting the proportion of "old" responses to new lure pairs (FAN) from the proportion of "old" responses to rearranged lure pairs (e.g. Abe et al, 2011;Budson et al, 2006aBudson et al, , 2006bHudon et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, pair repetition also increases false recognition, especially in healthy older people, as stimulus repetition increases the familiarity of the items (Tussing and Green, 2001), leading to more false alarms on rearranged pairs (Light et al, 2004;Rhodes et al, 2008). However, young adults, as their recollection-based recognition ability is intact, use practice to enhance recollection and reduce their false alarm rates on rearranged pairs (e.g., using the "recall-to-reject" strategy, which involves rejecting a non-studied XY lure pair because the participant can consciously recollect that stimulus X was associated with stimulus Z during the study task, and not with stimulus Y; see Abe et al (2011), Cohn et al (2008 and Gallo et al (2004)). This "recallto-reject" strategy, where recollection combats familiarity in young adults to reduce false recognition, has found extensive experimental support (e.g.…”

Section: Introductionmentioning

confidence: 99%

The effects of healthy aging, amnestic mild cognitive impairment, and Alzheimer's disease on recollection, familiarity and false recognition, estimated by an associative process-dissociation recognition procedure

et al. 2016

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a b s t r a c tGiven the uneven experimental results in the literature regarding whether or not familiarity declines with healthy aging and cognitive impairment, we compare four samples (healthy young people, healthy older people, older people with amnestic mild cognitive impairment -aMCI -, and older people with Alzheimer's disease -AD -) on an associative recognition task, which, following the logic of the processdissociation procedure, allowed us to obtain corrected estimates of recollection, familiarity and false recognition. The results show that familiarity does not decline with healthy aging, but it does with cognitive impairment, whereas false recognition increases with healthy aging, but declines significantly with cognitive impairment. These results support the idea that the deficits detected in recollection, familiarity, or false recognition in older people could be used as early prodromal markers of cognitive impairment.

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“…When processing stimuli that share perceptual characteristics, the LCR participants seem to first encode the stimuli through weaker episodic traces than young people, mistakenly combining features from studied events due to their binding deficits (Old & Naveh-Benjamin, 2008). Second, their retrieval can produce misrecollections or source monitoring errors, produced by their inability to use recall to reduce false recognition (Abe et al, 2011;Gallo et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…There is also a large body of research showing that false recognition (and false memories) increases with age in healthy people (e.g., Abe et al, 2011;Dodson, Bawa, & Slotnick, 2007;Hildebrandt, Haldenwanger, & Eling, 2009;McCabe, Roediger, McDaniel, & Balota, 2009;Norman & Schacter, 1997). Associative recognition is an optimal paradigm for studying false recognition in older people (Cohn & Moscovitch, 2007), because it has been established that aging causes more impairment in recognition memory for associations than for components (e.g., Boywitt, Kuhlmann, & Meiser, 2012;Kilb & NavehBenjamin, 2011;Old & Naveh-Benjamin, 2008;Rhodes, Castel, & Jacoby, 2008).…”

Section: Introductionmentioning

confidence: 99%

Differences in false recollection according to the cognitive reserve of healthy older people

Pitarque

Meléndez

Sales

et al. 2016

Aging, Neuropsychology, and Cognition

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We present an associative recognition experiment comparing three samples of healthy people (young people, older people with high cognitive reserve [HCR], and older people with low cognitive reserve [LCR], with each sample consisting of 40 people), manipulating stimuli repetition during the study phase. The results show significant differences among the three samples in their overall performance. However, these differences are not due to a different use of familiarity, but rather due to a different way of using recollection: although there are no differences in the hit rates between the HRC and LRC samples, the LCR group makes significantly more recollective false alarms than the HCR group. Moreover, repetition provokes an increase in the recollective false alarms in the LCR group, but this does not occur in the group of young people or in the HCR group. These findings are explained in terms of recollection-based monitoring errors and seem to provide support for the cognitive reserve hypothesis. ARTICLE HISTORY

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False item recognition in patients with Alzheimer's disease

Cited by 35 publications

References 49 publications

Neuroimaging Studies of False Memory: A Selective Review

Neuroimaging Studies of False Memory: A Selective Review

The effects of healthy aging, amnestic mild cognitive impairment, and Alzheimer's disease on recollection, familiarity and false recognition, estimated by an associative process-dissociation recognition procedure

Differences in false recollection according to the cognitive reserve of healthy older people

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