False-negative frozen section of sentinel lymph node biopsy for breast cancer

Holck, Susanne; Galatius, Hanne; Engel, Uwe; Wagner, F.; Hoffmann, J

doi:10.1016/s0960-9776(03)00124-3

Cited by 46 publications

(30 citation statements)

References 41 publications

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“…Sensitivities between 92% and 100% to detect SLN macro-metastases are reported in the literature [11][12][13][14][15][16]. Other series which did not distinguish between macro-and micro-metastases reported sensitivities for SLN frozen section between 54% and 94% [17][18][19][20][21][22][23][24][25][26] (Table 3). These large variations reflect the different histopathological techniques used for frozen section analyses and final histopathology.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of frozen section of sentinel lymph nodes: a prospective analysis of 659 breast cancer patients of the Swiss multicenter study

Langer

Güller

Berclaz

et al. 2008

Breast Cancer Res Treat

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SLN frozen section provides highly accurate information regarding identification of SLN macro-metastases, a delayed completion ALND can be avoided in 98% of these patients. More importantly, in the present investigation the vast majority (96%) of patients with SLN micro-metastases or isolated tumor cells undergoing delayed completion ALND did not benefit from the second operation as ALND specimens were free of macro-metastases. We strongly recommend the routine use of SLN frozen section in early stage breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Accuracy of frozen section of sentinel lymph nodes: a prospective analysis of 659 breast cancer patients of the Swiss multicenter study

Langer

Güller

Berclaz

et al. 2008

Breast Cancer Res Treat

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“…De plus, la signification et l'attitude thérapeutique devant la découverte de micrométastases restent controversées [20]. Certaines équipes [21] réalisent un complément de curage ganglionnaire lorsqu'il existe au moins une micrométastase bien que cette attitude ne soit pas validée [22]. L'intérêt d'une prise en charge chirurgicale active des micrométastases n'est en effet pas démontré même si leur présence semble avoir un impact négatif sur la survie globale des patientes [23].…”

Section: Discussionunclassified

Existe-t-il encore une place pour l'examen extemporané dans le cancer du sein ?

Michy

Bouëdec

Mishellany

et al. 2006

Gynécologie Obstétrique & Fertilité

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“…This is not surprising, because ILC as a histologic subtype of breast carcinoma remains a challenge for histopathologic evaluation. 4,12 It metastasizes to lymph nodes in a scattered fashion, lacking severe cytologic atypia. Metastatic cells tend to fill the sinuses, mimicking sinus histiocytosis.…”

Section: Discussionmentioning

confidence: 99%

“…1,4,5 To date, studies have attempted to solve the problem of low diagnostic sensitivity by implementing intraoperative (IHC). 6 -9 These studies are based on a small study population and have been inconclusive in resolving the added value of IHC in histologic subgroups of breast carcinoma.…”

mentioning

confidence: 99%

Rapid immunohistochemistry enhances the intraoperative diagnosis of sentinel lymph node metastases in invasive lobular breast carcinoma

Leikola¹,

Toivonen²,

Krogerus³

et al. 2005

Cancer

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The main objective of the work is to compare the growth and nutritional status of Australian Aboriginal term infants born with (n = 81) and without fetal growth restriction (n = 260). A prospective birth cohort study of 341 Aboriginal babies from the Top End of the Northern Territory of Australia was recruited at birth (1987–1990) and re‐examined at a mean age of 18.3 years (2006–2008) for outcome measures of growth and nutrition status. Those with growth restriction at birth were 3 cm shorter (P = 0.0026) and 9 kg lighter (P = 0.0001) with head circumferences 0.95 cm smaller (P = 0.0008) than those without growth restriction. The proportions of growth restricted participants with body mass index <18.5 kg/m2 were significantly greater (P = 0.028), and those with BMI > 25 kg/m2 and with fat percentage >85th percentile were significantly smaller (P = 0.012 and 0.004, respectively). In this cohort, those Aboriginal babies born smaller and lighter have remained smaller and lighter at 18 years of age. However, the highest risk of later chronic noncommunicable disease has been reported in subjects who were born small and become relatively larger in later life. The continued study of this Aboriginal birth cohort will give us an opportunity to determine if and when in later life the effects of birth weight are modified by environmental nutritional factors. Am. J. Hum. Biol., 2011. © 2010 Wiley‐Liss, Inc.

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False-negative frozen section of sentinel lymph node biopsy for breast cancer

Cited by 46 publications

References 41 publications

Accuracy of frozen section of sentinel lymph nodes: a prospective analysis of 659 breast cancer patients of the Swiss multicenter study

Accuracy of frozen section of sentinel lymph nodes: a prospective analysis of 659 breast cancer patients of the Swiss multicenter study

Existe-t-il encore une place pour l'examen extemporané dans le cancer du sein ?

Rapid immunohistochemistry enhances the intraoperative diagnosis of sentinel lymph node metastases in invasive lobular breast carcinoma

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