False positive effect of sulfur sources used in growing and processing of vine (<i>Vitis Vinifera</i>L.) leaves on the results of dithiocarbamate analysis based on carbon disulfide measurement

Arslan, Sinan; Güler, Ali; SAVAŞ, Nurdan GÜNGÖR; Dağaşan, Ö.; Yiğitkaya, Sema; Kale, Leyla Yeşim; Numanoğlu, Eren; Balaban, Beyza; Özaltın, Kadir Emre; Merken, Özen; Kacar, Güneş

doi:10.1080/19440049.2022.2093987

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…In addition, the quantication of the total carbon disulde is affected by false positive effects due to suldes other than DTC in the environment. 15 Surface assisted laser desorption ionization (SALDI) is a technique to indirectly desorb and ionize sample molecules through the absorption of pulsed laser power by inorganic nanoparticles or a plate with a nanostructured surface. 16,17 SALDI/MS is a mass spectrometric technique using a nanostructured surface instead of matrices, and that reduces the background noise in the low m/z range (<500 Da) compared to those by MALDI/MS.…”

Section: Introductionmentioning

confidence: 99%

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Direct detection of dithiocarbamate fungicides by SALDI/MS using porous TiC ceramic powder as a substrate

Moriwaki,

Osaka,

Hashimoto

et al. 2024

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

“…In addition, the quantification of the total carbon disulfide is affected by false positive effects due to sulfides other than DTC in the environment. 15…”

Section: Introductionmentioning

confidence: 99%

Direct detection of dithiocarbamate fungicides by SALDI/MS using porous TiC ceramic powder as a substrate

Moriwaki,

Osaka,

Hashimoto

et al. 2024

Anal. Methods

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“…Dithiocarbamates are an important class of sulfur-containing organic compounds with a wide range of applications in both academia and industry [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. They serve as fungicides and pesticides in agriculture [ 17 , 18 , 19 ], vulcanization agents in the rubber industry [ 20 ], radical chain transfer agents in polymerization [ 21 ], effective ligands in coordination chemistry [ 22 ], and, last but not least, as biologically important structural motifs in medicinal chemistry ( Scheme 2 ) [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Oleanolic Acid-Dithiocarbamate Conjugates and Evaluation of Their Broad-Spectrum Antitumor Activities

Tang

Zhang

et al. 2023

Molecules

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Efficient and mild synthetic routes for bioactive natural product derivatives are of current interest for drug discovery. Herein, on the basis of the pharmacophore hybrid strategy, we report a two-step protocol to obtain a series of structurally novel oleanolic acid (OA)-dithiocarbamate conjugates in mild conditions with high yields. Moreover, biological evaluations indicated that representative compound 3e exhibited the most potent and broad-spectrum antiproliferative effects against Panc1, A549, Hep3B, Huh-7, HT-29, and Hela cells with low cytotoxicity on normal cells. In terms of the IC50 values, these OA-dithiocarbamate conjugates were up to 30-fold more potent than the natural product OA. These compounds may be promising hit compounds for the development of novel anti-cancer drugs.

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Synthesis and antitumor evaluation of glycyrrhetinic acid‐dithiocarbamate hybrids

Su,

Wang,

et al. 2024

Archiv der Pharmazie

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Glycyrrhetinic acid (GA) is a naturally occurring triterpene compound. The aim of this study was to employ the pharmacophore hybrid strategy to merge GA with various dithiocarbamates and obtain novel compounds with better antitumor activities. We present a two‐step synthetic protocol wherein the GA derivative underwent reaction with carbon disulfide and various secondary amines in a one‐pot manner under mild conditions, facilitating the preparation of a series of structurally novel GA‐dithiocarbamate derivatives. Bioassay screening revealed that the representative compound 3c demonstrated the capacity to reduce the mitochondrial membrane potential in Hep3B and Huh‐7 cells, induce nuclear apoptosis, inhibit invasion and migration, and prompt both early and late apoptosis. Furthermore, our research findings indicated that this apoptotic phenomenon may be associated with the expression of Bcl‐2, Bax, Bak, PARP, and cleaved‐PARP proteins. Utilizing network pharmacology for predicting core targets and signaling pathways of compound 3c for hepatocellular carcinoma (HCC) treatment involved employing molecular docking models to demonstrate high affinity between compound and target protein. In conjunction with Western blot analysis, compound 3c may impact HCC through the PI3K‐AKT‐mTOR pathway.

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False positive effect of sulfur sources used in growing and processing of vine (Vitis ViniferaL.) leaves on the results of dithiocarbamate analysis based on carbon disulfide measurement

Cited by 3 publications

References 23 publications

Direct detection of dithiocarbamate fungicides by SALDI/MS using porous TiC ceramic powder as a substrate

Direct detection of dithiocarbamate fungicides by SALDI/MS using porous TiC ceramic powder as a substrate

Synthesis of Oleanolic Acid-Dithiocarbamate Conjugates and Evaluation of Their Broad-Spectrum Antitumor Activities

Synthesis and antitumor evaluation of glycyrrhetinic acid‐dithiocarbamate hybrids

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