False-Positive FDG Positron Emission Tomography Uptake in Nonmalignant Chest Abnormalities

Asad, Syed Daniyal; Aquino, Suzanne L.; Piyavisetpat, Nitra; Fischman, Alan J.

doi:10.2214/ajr.182.4.1820983

Cited by 75 publications

(35 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 Additionally, if tumour implants are smaller than 5 mm, they may not be detected by conventional imaging. 18 In our study, the overall sensitivity, specificity, PPV, NPV, and accuracy of PET/CT was 81.8%, 54.5%, 64.3%, 75%, and 68.2% for patients with pleural thickening and 100%, 56.5%, 41.1%, 100%, and 60% for patients with pleural fluid, respectively. Two patients were diagnosed with epithelioid-type MPM with false-negative PET findings in the pleural thickening group, and five patients were diagnosed with epithelioid-type MPM in the pleural fluid group.…”

Section: Discussionsupporting

confidence: 51%

Accuracy of 18-FDG PET/CT in the Differential Diagnosis of Malignant and Benign Pleural Diseases

Ceylan¹

2013

UHOD

View full text Add to dashboard Cite

Integrated whole-body 18-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) is a non-invasive imaging technique for identifying several types of malignant diseases. We evaluated the role of PET/CT in distinguishing malignant from benign pleural diseases. Thirty patients, who had pleural abnormalities on computed tomography (CT), such as thickening, fluid with suspicion of malignant pleural mesothelioma or any other malignancy underwent PET/CT. Maximum standardized uptake values (SUVmax) were calculated separately for pleural thickening and pleural fluid and compared with pathological results obtained by video thoracoscopy. Twenty-two patients with pleural thickening and 25 patients with pleural fluid were assessed with regard to the accuracy of PET/CT. The overall sensitivity,specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT was 81.8%, 54.5%, 64.3%, 75%, and 68.2% for pleural thickening and it was 100%, 56.5%, 41.1%, 100%, and 60% for patients with pleural fluid. When the pleural thickening was evaluated, the SUVmax values were higher in the malignant pleural diseases than in the benign pleural diseases but the difference was not statistically significantly (p = 0.063). When the pleural fluid was evaluated, the SUVmax values were also higher in the malignant pleural diseases than in the benign pleural diseases and the difference was statistically significantly (p= 0.03). The accuracy of PET/CT for detecting malignant pleural fluids was high. However, PET/CT was not adequate to make the differential diagnosis of pleural malignancies especially in case of pleural thickening because of its relatively low sensitivity,specificity,PPV, and NPV. A tissue biopsy is necessary to determine the diagnosis. Keywords: 18-fluorodeoxiglucose-positron emission tomography, Pleural Disease ÖZET Malign ve Benign Plevral Hastal›klar›n Ay›r›c› Tan›s›nda 18-FDG PET/BT'nin Etkinli¤iTüm vücut 18-florodeoksiglukoz pozitron emisyon tomografi /bilgisayarl› tomografisi (PET / BT) birçok malign hastal›¤›n tan›s›nda kullan›lan non-invaziv bir hibrid görüntüleme tekni¤idir. Çal›flmam›zda malign ve benign plevral hastal›klar›n ay›r›c› tan›s›nda PET / BT'nin etkinli¤i de¤erlendirildi. Bilgisayarl› tomografide malign plevral mezotelyoma ve di¤er malignite flüphesi oluflturan plevral kal›nlaflma veya plevral s›v›s› saptanan 30 hastaya PET / BT uyguland›. SUVmax de¤erleri plevral kal›nlaflma ve plevral s›v› için ayr› ayr› hesaplanarak video torakoskopi ile elde edilen patoloji sonuçlar› ile karfl›laflt›r›ld›. Plevral kal›nlaflmas› olan 22 hasta ve plevral s›v›s› olan 25 hasta PET / BT etkinli¤i aç›s›ndan de¤erlendirildi. Plevral kal›nlaflma için duyarl›l›k, özgüllük, pozitif prediktif de¤er (PPV), negatif prediktif de¤eri (NPD) ve PET / BT'nin etkinlik oran› s›ras›yla %81.8, %54.5, %64.3, %75 ve %68.2, plevra s›v› için s›ras›yla %100, %56.5, %41.1, %100 ve %60 idi. Plevral kal›nlaflma için bak›ld›¤›nda SUVmax de¤erleri malign hastalarda daha yüksek olmakla beraber...

show abstract

Section: Discussionsupporting

confidence: 51%

Accuracy of 18-FDG PET/CT in the Differential Diagnosis of Malignant and Benign Pleural Diseases

Ceylan¹

2013

UHOD

View full text Add to dashboard Cite

show abstract

“…They may consist of fat, epithelial, fibrous or chondroid tissues. Popcorn calcification may be seen in some cases [4,10,11] which is a highly diagnostic feature when seen on chest CT but mostly CT findings are nonspecific as in our case that doesn't have the specific popcorn calcification.…”

Section: Discussionmentioning

confidence: 74%

“…Hamartoma is the most common benign tumor of the lung containing normal pulmonary tissue including bronchi, cartilage and fat [1] . It is mostly asymptomatic and show no FDG uptake on PET [1,2] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary hamartoma with low FDG uptake: A case report

Çakmak

Selcuk

Savas

2014

CRIM

View full text Add to dashboard Cite

Introduction: Pulmonary hamartomas are the most common benign tumors of the lung. It usually shows no FDG uptake and has a low risk for malignant transformation. We present a rare case of pulmonary hamartoma with low Fluorodeoxyglucose uptake to call attention to the low malignancy potential of this benign tumor.Case presentation: 67-year old male patient on the preoperative evaluation for his lumbar disc surgery was found out to have a solid lesion detected on chest computed tomography with low Fluorodeoxyglucose uptake. Conclusion:Pulmonary hamartomas are benign tumors. But although their benignity they may show Fluorodeoxyglucose uptake and also they have a low risk for malignant transformation. So they should be followed up closely.

show abstract

“…The pleural deposits stimulate a chronic granulomatous reaction that may be FDG-avid and thus mimic tumor recurrence on PET in patients treated for pulmonary or pleural malignancy (see Figure 15). The characteristic high CT attenuation of talc density from matched FDG-avid curvi-linear features helps to differentiate this entity from pleural tumors [1,25] .…”

Section: Trauma Iatrogenic and Post-procedural Changesmentioning

confidence: 99%

Features of non-malignant thoracic lesions on F-18 FDG PET/CT scan

Nguyen

2014

IJDI

View full text Add to dashboard Cite

Introduction: During PET/CT chest interpretation, the radiologist may encounter non-malignant positive findings originating from physiologic variants, inflammation, infection, iatrogenic causes, post-surgical/post-therapeutic changes and benign tumors of different components of the thorax. This article illustrates and raises the awareness of these benign FDG-avid findings. Methods:We use a search engine to retrospectively review the 10-year PET/CT and pathology database of our institution for cases with thoracic findings linked to physiologic variations, and to benign processes and diseases. The keywords used for the search include all the entities presented in this article. We select the cases presenting with the most didactic value of benignity related to (1) established imaging patterns already published in the literature, which serves as reference articles in this paper, (2) final diagnosis from tissue sampling of ambiguous and difficult cases, and (3) long term monitoring based on clinical evaluation and anatomic and functional imaging.Results: Among the pool of cases fulfilling the required search criteria, we choose the most illustrative ones to present the different categories of benign findings encompassing the physiologic variants, inflammation, infection, iatrogenic causes, post-operative and post-therapeutic changes, and benign neoplasms. The most representative reference articles of the presented cases concerning all the benign thoracic entities are selected for the bibliography. Conclusion:The presented PET/CT cases raise the awareness and strengthen the interpretation confidence of the radiologist during the evaluation of cancer. The familiarity with these benign thoracic entities would obviate any suspicion of malignancy and avoid unnecessary additional assessment using expansive and potentially harmful procedures.

show abstract

False-Positive FDG Positron Emission Tomography Uptake in Nonmalignant Chest Abnormalities

Cited by 75 publications

References 8 publications

Accuracy of 18-FDG PET/CT in the Differential Diagnosis of Malignant and Benign Pleural Diseases

Accuracy of 18-FDG PET/CT in the Differential Diagnosis of Malignant and Benign Pleural Diseases

Pulmonary hamartoma with low FDG uptake: A case report

Features of non-malignant thoracic lesions on F-18 FDG PET/CT scan

Contact Info

Product

Resources

About