False positive MIBG scan

Abstract

The fortuitous discovery of a left posterior cervico‐mediastinal mass during hospitalization for hemolytic anemia in an 18 month old baby is reported. Metaiodobenzylguanidine (MIBG) uptake suggested a sympathetic tissue origin of the mass despite negative catecholamines excretion, but histopathologic examination revealed a juvenile capillary angioma within a normal sympathic ganglion. Med. Pediatr. Oncol. 29:589–592, 1997. © 1997 Wiley‐Liss, Inc.

False-Positive Accumulation of Metaiodobenzylguanidine in a Case with Acute Intermittent Porphyria

“…One major cause of falsepositive findings is urinary tract retention, since the reagent is excreted in the urine (12). Other rare false-positive MIBG accumulations have been reported in the adrenal gland with adenoma (13), carcinoma (14) or metastatic choriocarcinoma, and adenomatous polyp of the cecum, infantile myofibromatosis (15), pancreatoblastoma (15), acute focal pyelonephritis, hepatic hemangioma, hepatocellular carcinoma (16), and juvenile capillary hemangioma (17). The non-specific accumulation of MIBG is thought to be mediated by a passive uptake and diffusion.…”

False-positive radio-iodinated metaiodobenzylguanidine (123I-MIBG) accumulation in a mast cell-infiltrated infantile haemangioma

“…The high specificity of 123 I-MIBG accumulation is useful for the classification of tumours, such as pheochromocytomas, neuroblastomas or carcinoids, in the area of the I-MIBG uptake have been described, including haemangiomas [6,7].…”

“…This specific uptake and storage mechanism provides the basis for the imaging of neuroendocrine tumours such as pheochromocytomas and neuroblastomas. Nevertheless, cases of false-positive 123 I-MIBG scintigraphy with accumulation in non-chromaffin tumours such as angiomyolipoma [3], adrenocortical carcinoma [4], adrenocortical adenoma [5], juvenile capillary angioma [6] or cavernous haemangioma [7] have been described. Here, we present another case of a falsepositive 123 I-MIBG scan of a tumour within the adrenal gland area and discuss the possible mechanism.…”

Cervical Ganglioneuroblastoma Mimicking Thyroid Tissue in a Young Adult: Differential Diagnosis

“…4 An cak nö rob las tik tü mör, fe ok ro ma sito ma, kar si no id tü mör, me dül ler ti ro id kan se ri gibi sem pa tik do ku kay nak lı tü mör ayı rı mı nı ya pa maz. 4 Ul tra so nog ra fik in ce le me de nor mal tiro id do ku su nu gör dü ğü müz den sin tig ra fik gö rün -tü le me uy gu la ma dık. Tü mö rün I…”

“…Gang li o nö rob las to ma da tüm sem pa tik ağın pel vi se ka dar in ce len me si nin ikin ci bir odak ve ya Turkiye Klinikleri J Med Sci 2011;31 (4) …”