False-Positive Plasma Troponin I with the AxSYM Analyzer

Galambos, Csaba; Brink, David S.; Ritter, Detlef; Chung, Hyung D.; Creer, Michael H.

doi:10.1093/clinchem/46.7.1014

Cited by 15 publications

(7 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include heterophilic antibodies, 34 rheumatoid factor, 35 fibrin clots, 36 microparticles, 36 and malfunction of the analyzer itself. 37 The role of heterophilic antibodies in causing interference in immunoassays has been reported in a number of studies. 34,38 -41 The incidence of this interference varies considerably in the literature, 40 -43 ranging from 0.17 to 40%.…”

Section: False-positive Troponinmentioning

confidence: 99%

“…Finally, malfunction of the analyzer itself is another reported cause of false elevations in cardiac TnI results. Galambos et al 37 reported several cases of falsely elevated plasma cardiac TnI levels due to a temporary malfunction of the AxSYM analyzer (Abbott Laboratories; Abbott Park, IL). The operation manual provided by the manufacturer mentions the possibility of a solution dispenser misalignment if the dispensers are repositioned incorrectly during the weekly maintenance.…”

Section: False-positive Troponinmentioning

confidence: 99%

See 1 more Smart Citation

Common Causes of Troponin Elevations in the Absence of Acute Myocardial Infarction

Roongsritong

Warraich

Bradley

2004

Chest

218

139

View full text Add to dashboard Cite

Section: False-positive Troponinmentioning

confidence: 99%

Section: False-positive Troponinmentioning

confidence: 99%

Common Causes of Troponin Elevations in the Absence of Acute Myocardial Infarction

Roongsritong

Warraich

Bradley

2004

Chest

218

139

View full text Add to dashboard Cite

“…Other endogenous substances such as rheumatoid factor, excess fibrin, and endogenous alkaline phosphatase can also produce false-positive results. [12][13][14] Our laboratory uses the AccuTnIC3 assay, which uses monoclonal antibodies specifically directed against human cardiac troponin I. The AccuTnIC assay uses mouse monoclonal antihuman cTnI alkaline phosphatase conjugate and uses a surfactant, bovine serum albumin matrix, and protein (bovine, goat, mouse) as reagents.…”

Section: Discussionmentioning

confidence: 99%

Multiple admissions to the coronary care unit due to falsely elevated cardiac troponin

Ayan

Gheith

Ananthula

et al. 2018

Baylor University Medical Center Proceedings

View full text Add to dashboard Cite

The measurement of cardiac troponin, released from injured cardiomyocytes, is of paramount importance in the diagnosis of acute myocardial infarction. Elevated troponin can be encountered, however, in patients with cardiomyopathy, significant cardiac arrhythmias, vasculitis, right-sided heart strain, critical systemic illnesses, stroke, drug toxicity (such as Adriamycin), poisons (such as snake venoms), renal failure, seizure, and rhabdomyolysis. If the clinical picture is not consistent with any of these causes, a false-positive result should be considered. We herein describe a 94-year-old man with a prior history of coronary artery disease who presented with altered mental status and was found to have a persistently high troponin level resulting in three admissions to the coronary care unit for various noncardiac complaints. Because of discordance between clinical and laboratory data, immunological interference due to heterophile antibodies in the locally used assay (AccuTnI+3, Beckman Coulter) was suspected. The same serum sample tested on a different assay (Elecsys Troponin I Assay, Roche) resulted in an undetectable cardiac troponin I level, thus confirming the diagnosis.

show abstract

“…Despite the advantages of troponins, clinicians should keep in mind other processes that elevate troponin levels apart from myocardial infarction. 2 , 3 , 6 , 7 , 8 , 9 , 10 , 11 While some of the events with troponin elevation other than myocardial infarction are associated with myocardial injury, some of them occur as a result of troponin tests giving false positive results.…”

Section: Discussionmentioning

confidence: 99%

“…False positive troponin testing may result from: heterophile antibodies, Rheumatoid factor, or macroenzymes. Several additional examples of interfering substances are found in the literature; 3 , 10 , 11 among which are circulating antibodies from immunotherapies, vaccinations or blood transfusions, fibrin clots, immunocomplexes, and malfunction of the analyzers.…”

Section: Discussionmentioning

confidence: 99%

False Positive Troponin Levels due to Heterophil Antibodies in a Pregnant Woman

Kaplan

Orhan

Erkan

2015

Turkish Journal of Emergency Medicine

View full text Add to dashboard Cite

SUMMARYPositive troponin test results in peripheral blood can be detected either during myocardial injury or from falsely positive test results. In this report, we present the positive results of a troponin test in a 24-year-old pregnant woman referred to the emergency department with atypical chest pain, and the clinical algorithm that we used to make the correct diagnosis. This patient presented with the same complaint of chest pain at different times while positive troponin levels were detected. In the absence of signs of myocardial injury, we suspected that heterophil antibodies were playing a major role. Further examinations revealed heterophil antibodies that could cross react with the troponin tests in peripheral blood.

show abstract

False-Positive Plasma Troponin I with the AxSYM Analyzer

Cited by 15 publications

References 1 publication

Common Causes of Troponin Elevations in the Absence of Acute Myocardial Infarction

Common Causes of Troponin Elevations in the Absence of Acute Myocardial Infarction

Multiple admissions to the coronary care unit due to falsely elevated cardiac troponin

False Positive Troponin Levels due to Heterophil Antibodies in a Pregnant Woman

Contact Info

Product

Resources

About