False Positive Uptake in Post-treatment Iodine-131 Whole-Body Scans Secondary to Contamination

Schlosser, J.; Paliou, Maria; Bravo-Vera, Rafael; Sheikh, Arsalan; Gouller, Alina

doi:10.1089/thy.2005.0085

Cited by 8 publications

(3 citation statements)

References 2 publications

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“…Misinterpretations of physiologic or benign pathologic uptakes of radioiodine or contamination as being metastatic lesions of thyroid cancer could lead to unnecessary surgery or the administration of therapeutic I-131 resulting in unnecessary fruitless radiation exposure (3,5,7). Many falsepositive findings have been documented in radioiodine scans, but radioiodine uptake by fungus balls related to aspergilloma is extremely rare and typically the subject of single case reports (4,8).…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary Aspergilloma Mimicking Metastasis from Papillary Thyroid Cancer

Ahn

Lee²,

Lee³

et al. 2011

Thyroid

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Section: Discussionmentioning

confidence: 99%

“…However, a variety of unusual lesions may cause falsepositive results, and therefore, abnormal scans must be carefully evaluated to avoid unnecessary surgical removal or high-dose radioiodine treatment (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Aspergilloma Mimicking Metastasis from Papillary Thyroid Cancer

Ahn

Lee²,

Lee³

et al. 2011

Thyroid

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“…Contamination artifacts are caused by radioiodinated bodily fluids on the skin, hair, and clothes. Perspiration can result in skin and hair contamination in the axilla [86] and scalp [87]. Contamination has also been described in artificial eyeballs by tear contamination [88 • , 89 • ] and within tracheostomy sites [90].…”

Section: Contamination By Radioiodinated Bodily Fluidmentioning

confidence: 99%

Causes of False-Positive Radioactive Iodine Uptake in Patients with Differentiated Thyroid Cancer

Ozomaro

Flavell

et al. 2021

Curr Radiol Rep

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Purpose Radioactive iodine (RAI) whole-body scan is a sensitive imaging modality routinely used in patients with differentiated thyroid cancer to detect persistent and recurrent disease. However, there can be false-positive RAI uptake that can lead to misdiagnosis and misclassification of a patient’s cancer stage. Recognizing the causes of false positivity can avoid unnecessary testing and treatment as well as emotional stress. In this review, we discuss causes and summarize various mechanisms for false-positive uptake. Recent Findings We report a patient with differentiated thyroid cancer who was found to have Mycobacterium avium complex infection as the cause of false-positive RAI uptake in the lungs. Using this case example, we discuss and summarize findings from the literature on etiologies of false-positive RAI uptake. We also supplement additional original images illustrating other examples of false RAI uptake. Summary False-positive RAI uptake may arise from different causes and RAI scans need to be interpreted in the context of the patient’s history and corresponding cross-sectional imaging findings on workup. Understanding the potential pitfalls of the RAI scan and the mechanisms underlying false uptake are vital in the care of patients with differentiated thyroid cancer.

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