False positivity of FDG‐PET/CT in a child with Hodgkin disease

Beker, Dildar Bahar; Berrak, Su Gülsün; Canpolat, Cengiz; Tuğtepe, Halil; Öneş, Tunç; Tecimer, Tülay

doi:10.1002/pbc.21197

Cited by 13 publications

(8 citation statements)

References 7 publications

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“…An open biopsy, however, revealed nodal RFH [6]. Similar findings were observed by Beker et al [2] in a 7-year-old child with Hodgkin lymphoma. The patient was considered cured, but 18 F-FDG uptake in the abdomen was observed, which microscopically revealed RFH.…”

Section: Discussionsupporting

confidence: 88%

“…During the follow-up, negative FDG-PET/CT scans almost exclude a relapse of the disease, but 18 F-FDG uptake does not necessarily means its returns [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…18 F-FDG accumulation in the major salivary glands, spinal cord, and vocal cords is variable; whereas in the inferior concha, thyroid gland, and tongue is typically minimal [4]. In lymphoma patients, unfortunately, false-positive results are possible, because an infection, inflammation, hypermetabolic brown fat surrounding lymph nodes or reactive process producing strong 18 F-FDG uptake might be present [2,[5][6][7][8]. In these cases, and not uncommonly after chemotherapy, reactive enlargement of the lymph nodes, tonsils, and thymus gland can be detected [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Reactive Tonsillar Enlargement Showing Strong 18F-Fdg Uptake During the Follow-Up of Follicular Lymphoma

Feio

Gomes

Nogueira

et al. 2012

Head and Neck Pathol

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The 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become a standard procedure for the diagnosis, staging, and restaging in lymphoma patients. However, a relative high rate of false-positive results has been reported. We report a case of a 40-year-old man with a previous history of a nodal follicular lymphoma, stage IVA, treated with R-CHOP, which showed strong 18 F-FDG uptake in the Waldeyer's tonsillar ring during his follow-up, being considered highly suspicious of relapsed lymphoma. A surgical removal of the palatine tonsils and adenoids was performed, which showed reactive follicular hyperplasia. Furthermore, bone marrow biopsy revealed absence of neoplasia. The patient is still in follow-up with no signs of recurrent lymphoma. This case illustrates that, despite the high sensitivity for the detection of recurrent lymphoma, 18 F-FDG uptake should be interpreted with great caution and confirmatory studies should be performed before any therapy.

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Section: Discussionsupporting

confidence: 88%

“…During the follow-up, negative FDG-PET/CT scans almost exclude a relapse of the disease, but 18 F-FDG uptake does not necessarily means its returns [1,2].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reactive Tonsillar Enlargement Showing Strong 18F-Fdg Uptake During the Follow-Up of Follicular Lymphoma

Feio

Gomes

Nogueira

et al. 2012

Head and Neck Pathol

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“…In addition to being more cost-effective, there is considerably less radiation exposure to patients undergoing PET/CT alone. [8,9] …”

Section: Clinical Applications Of Pet/ct In Childrenmentioning

confidence: 98%

“…A retrospective study [8,9] was done to compare the performance of PET/ low-dose CT and diagnostic CT in the follow-up of children with lymphoma. The data collected consisted of nodal and extra-nodal disease in the neck, chest, abdomen, and pelvis, as well as incidental findings.…”

Section: Clinical Applications Of Pet/ct In Childrenmentioning

confidence: 99%

PET/CT in pediatric oncology

Samuel¹

2010

Indian J Cancer

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Radionuclide functional imaging has become a central part of pediatric oncological practice. There have been a number of major advances in imaging technology in recent years, but multislice CT with PET is the modality generating most interest in cancer imaging. In this review, we discuss the common uses and specific issues with regard to PET-CT imaging in pediatric practice. Brain tumors form a significant percentage of pediatric oncology. Use of FDG-PET in brain tumors has helped distinguish viable, residual, or recurrent tumor from post-therapeutic changes and necrosis. High-grade tumors show high uptake of FDG at diagnosis. FDG-PET results may also not accurately correlate with tumor progression after intensive radiation therapy. FDG-PET has been applied to accurate biopsy of infiltrative tumors, tumor grading, and prognostication. Limited available data also suggest that FDG-PET findings correlate well with histopathology and clinical outcome in children. FDG uptake is generally greater in higher grade lymphomas than in lower grade lymphomas. FDG-PET reveals disease sites that are not detected by conventional staging methods, resulting in upstaging of disease with potential therapeutic review. FDG-PET is useful for assessing need for marrow biopsy, residual or recurrent soft tissue masses seen on CT after therapy. The primary role of FDG-PET in neuroblastoma is in non-MIBG concentrating tumors. [11C]-Hydroxyephedrine ([11C]-HED), an analogue of norepinephrine, and [11C]-epinephrine PET have also been used in evaluating neuroblastoma. Uptake of these tracers is demonstrated within minutes after tracer administration, an advantage over MIBG imaging. The exact roles of FDG-PET in osteosarcoma and Ewing's sarcoma are not definitive. FDG-PET may play an important role in monitoring response to therapy Another diagnostic role may be in assessing patients with suspected metastatic disease.

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