False positivity of gamma-glutamyl transpeptidase measurement in urine

Crivellenti, Leandro Zuccolotto; Mesa, Javier Sousa; Meirelles, Adriana Érica Wilkes Burton; Crivellenti, Sofia Borin; Mireya, Edna; Canola, Júlio Carlos; Hatayde, M. R.; Santana, Áureo Evangelista; Dantas, Márcio; Silva, Gyl Eanes Barros

doi:10.3109/0886022x.2014.880325

Cited by 8 publications

(9 citation statements)

References 10 publications

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“…Furthermore, induction of muscular inflammation with injection of Freund's complete adjuvant resulted in decreased uGGT/c in horses, and it was suggested that the presence of inflammation may affect the reliability of uGGT/c as an index of renal damage . One study reported that uGGT/c was increased after the administration of a nonnephrotoxic agent in dogs and concluded that this reflected false positive results . However, mild tubular damage might still have been missed on ultrastructural examination given the tendency for such lesions to be focally distributed.…”

Section: Renal Biomarkers: Urinementioning

confidence: 99%

Renal biomarkers in domestic species

Hokamp

Nabity

2016

Veterinary Clinical Pathol

140

147

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Current conventional tests of kidney damage and function in blood (serum creatinine and urea nitrogen) and urine (urine protein creatinine ratio and urine specific gravity) are widely used for diagnosis and monitoring of kidney disease. However, they all have important limitations, and additional markers of glomerular filtration rate and glomerular and tubular damage are desirable, particularly for earlier detection of renal disease when therapy is most effective. Additionally, urinary markers of kidney damage and function may help localize damage to the affected portion of the kidney. In general, the presence of high- and intermediate-molecular weight proteins in the urine are indicative of glomerular damage, while low-molecular weight proteins and enzymes in the urine suggest tubular damage due to decreased reabsorption of proteins, direct tubular damage, or both. This review aims to discuss many of these new blood and urinary biomarkers in domestic veterinary species, focusing primarily on dogs and cats, how they may be used for diagnosis of renal disease, and their limitations. Additionally, a brief discussion of serum creatinine is presented, highlighting its limitations and important considerations for its improved interpretation in domestic species based on past literature and recent studies.

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Section: Renal Biomarkers: Urinementioning

confidence: 99%

Renal biomarkers in domestic species

Hokamp

Nabity

2016

Veterinary Clinical Pathol

140

147

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“…Em pequenas concentrações, pode ser encontrado em outros órgãos como fígado, pâncreas, baço, pulmões, intestino delgado, placenta, sistema nervoso central, próstata e coração (RUDOLPH e CORVALAN, 1992). A espectrofotometria é o método mais utilizado para sua dosagem urinária, porém outras técnicas também são descritas (CRIVELLENTI et al 2014).…”

Section: Gama Glutamiltransferase Urinária (Ggt Urinária)unclassified

“…Em contrapartida Crivellenti et al (2014) demonstram que aumento da GGT urinária pode não estar necessáriamente relacionada as alterações histopatológica dos rins em casos de intoxicação por substâncias não nefrotóxicas.…”

Section: Gama Glutamiltransferase Urinária (Ggt Urinária)unclassified

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Conceitos E Aplicabilidade Dos Principais Biomarcadores Na Nefrologia Veterinária – Revisão De Literatura

et al. 2017

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Concepts and applicability of main biomarkers in veterinary nephrology -literature review RESUMO ABSTRACTOs biomarcadores são substâncias específicas de um órgão ou tecido sob investigação, que são produzidas ou liberadas proporcionalmente à injúria ou doença intercorrente. Na nefrologia a análise dos biomarcadores renais permitiu melhor entendimento das doenças, diagnóstico precoce, além de respostas à terapia. Porém, na veterinária ainda existem muitas lacunas não respondidas ou com resultados questionáveis. O objetivo desta revisão de literatura foi abordar temas referentes aos principais biomarcadores renais visando sua realização técnica e aplicabilidade clínica. Biomarcadores, como a cistina C, a lipocalina associada com gelatinase de neutrófilos (NGAL), N-acetil-β-d-glucosaminidase (NAG), a gama glumatiltransferase urinária (GGT urinária), interleucina 18 (IL-18) e a dimetilarginina simétrica (SDMA) serão abordadas nessa revisão. Conclui-se que apesar dos biomarcadores renais serem uma ferramenta promissora para diagnóstico precoce, prognóstico e auxiliar no tratamento de nefropatias são ainda necessários maiores estudos na medicina veterinária buscando identificar suas particularidades clínicas.Palavras-chave: Doença renal crônica, lesão renal aguda, diagnóstico precoce.TBiomarkers are specific substances of an organ or tissue under investigation that are produced or released proportionally to the injury or disease. In nephrology the renal biomarkers allowed a better understanding of the disease, early diagnosis, and response to the therapy. However, there are still many unanswered or questionable gaps in veterinary medicine. The objective of this literature review was to discuss topics related to the renal biomarkers and their technical realization and clinical applicability. New biomarkers, such as cystine C, lipocalin associated with neutrophil gelatinase (NGAL), N-acetyl-β-d-glucosaminidase (NAG), urinary glutathyltransferase (urinary GGT), interleukin 18 (IL-18) and Symmetrical dimethylarginine (SDMA) will be addressed in this review. It is concluded that although renal biomarkers are a promising tool for early diagnosis, prognosis and help in the treatment of nephropathies, further studies in veterinary medicine are still necessary to identify their clinical characteristics and relevance.

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“…Reported disorders associated with increased values of uGGT are shown in Table 1. Urinary GGT activity has great potential in safety assessment studies (Narita et al 2007;Borges et al 2013) Nevertheless, Crivellenti et al (2014) reported false positive results of urinary GGT measurement in dogs poisoned by a non-nephrotoxic agent (Nerium oleander).…”

Section: Gamma-glutamyl Transpeptidasementioning

confidence: 99%

Urinary biomarkers of renal function in dogs and cats: a review

Kovaříková¹

2015

Vet. Med.

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Kidney diseases commonly affect dogs and cats. Early diagnosis of renal impairment may be challenging even when urinalysis is used to provide additional information. Serum creatinine concentration is often used in the diagnosis, but it is a relatively insensitive marker of renal function. Particular attention is aimed at the investigation of certain molecules that may occur in urine at elevated levels as a result of glomerular or tubular dysfunction. These changes may be found before the increase of serum creatinine levels. This review article summarises reports of urine biomarkers and their utility in detecting early kidney disease in dogs and cats. Detection of multiple urinary biomarkers in diagnosis of acute kidney injury and chronic kidney disease may increase specificity and sensitivity. Early diagnosis of reduced renal functional mass allows early therapeutic interventions which may decrease morbidity and mortality. Keywords: microalbuminuria; neutrophil gelatinase-associated lipocalin; N-acetyl-β-d-glucosaminidase; gammaglutamyl transpeptidase; immunoglobulin GAbbreviations AKI = acute kidney injury; ARF = acute renal failure; CKD = chronic kidney disease; CRP = C-reactive protein; GFR = glomerular filtration rate; GGT = gamma-glutamyl transpeptidase; HMW = high molecular weight; ICU = intensive care unit; IgG = immunoglobulin G; NAG = N-acetyl-β-d-glucosaminidase; NGAL = neutrophil gelatinaseassociated lipocalin; PTH = parathormone; RBP = retinol binding protein; UAC = urinary albumin to creatinine ratio; uGGT = urinary gamma-glutamyl transpeptidase; uNAG = urinary N-acetyl-β-d-glucosaminidase; UNCR = urinary neutrophil gelatinase-associated lipocalin to creatinine ratio; UPC = urinary protein to creatinine ratio; uRBP = urinary retinol binding protein; UTI = urinary tract infection

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False positivity of gamma-glutamyl transpeptidase measurement in urine

Cited by 8 publications

References 10 publications

Renal biomarkers in domestic species

Renal biomarkers in domestic species

Conceitos E Aplicabilidade Dos Principais Biomarcadores Na Nefrologia Veterinária – Revisão De Literatura

Urinary biomarkers of renal function in dogs and cats: a review

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