This paper reconsiders the degree to which the sign patterns of hypothesized structural arrays limit the possible outcomes for the sign pattern of the corresponding estimated reduced form. To now, the conditions under which any such restrictions would apply were believed to be very narrow, are rarely found to apply, and are virtually never investigated. As a result, current practice does not test the structural hypothesis in terms of the outcome of the estimated reduced form in terms of permissible reduced form sign patterns alone. This paper shows that such tests are always possible. Namely, that the sign patterns of the hypothesized structural arrays always limit the sign patterns that can be consistently taken on by the estimated reduced form. Given this, it is always possible to falsify a structural hypothesis based only upon the sign pattern proposed. Necessary conditions, algorithmic principles, and examples are provided to illustrate the analytic principle and the means of its application. JEL Classification: C15, C18, C51, C52 . 4 E.g., Hicks (1932) assumes the production function is homogeneous of degree one when demonstrating "Marshall's Rules" for the size of factor price elasticities. 5 Lady and Quirk (2007, 2010) showed that the LeChatelier Principle could be established based upon the sign pattern of β.6 Hale, et al (1999) reviews much of this literature. Additional citations are provided in the next section.7 Buck and Lady (2005) consider this problem using a traditional qualitative analysis and the stability hypothesis.