Abstract:The education or licensing process is essentially required for the proper anti-tumor function of natural killer (NK) cells. Although several models for education have been proposed, the genetic factors regulating these processes still remain largely elusive. Here we show that FAM13A (family with sequence similarity 13, member A), strongly linked to the risk of prominent death-causing lung diseases, i.e., lung cancer and chronic obstructive pulmonary disease, critically modulated NK cell maturation and effector… Show more
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