FAM3B Serves as a Biomarker for the Development and Malignancy of Oral Lichen Planus

Wang, Wenfang; Wang, Meijuan; Ahmed, Madiha Mohammed Saleh; Zhao, Yunshan; Wu, Hong; Musa, Mazen; Chen, Xi

doi:10.2147/ijgm.s346617

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Although genetic status, immune system background, and infectious diseases are considered to be the most important incriminating and determining factors, the etiopathogenesis of OLP remains poorly known [9].…”

Section: Genetics Updatementioning

confidence: 99%

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Oral Lichen Planus Genetics Update

Albu

Bencze

Dragomirescu

et al. 2022

EJDENT

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Lichen planus is a chronic autoimmune multi-factorial inflammatory condition of the mucocutaneous skin that mainly interests the skin and oral mucosa. Oral Lichen Planus (OLP) affects 0.5 to 1% of the world's population and all human races equally. The factors that act as triggers of autoimmune processes and determine the appearance of OLP are represented by genetic predisposition, skin injuries, viral infections, contact allergies, and medications. OLP affects the oral mucosa and occurs frequently on the inside of the cheeks and less often on the edges of the tongue, gums, or lips. The condition is manifested by the appearance of painful erosions and mouth ulcers, accompanied by erythema and gingival scaling, and sometimes localized inflammation of the gums, near the amalgam fillings. There are 132 genes currently involved in the etiopathogenesis of OLP, but only a few appear to play a major role. These genes have been termed "leader genes". Thus, based on bioinformatics studies, the main genes involved in the pathogenesis of OPL are JUN, EGFR, FOS, IL2, and ITGB4. Although genetic status, immune system background, and infectious diseases are considered to be the most important incriminating and determining factors, the etiopathogenesis of OLP remains poorly known. Further genetic research is needed in order to achieve the generalizability of the findings and to strengthen the obtaining results.

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Section: Genetics Updatementioning

confidence: 99%

“…Also, FAM3B could be also associated with the initiation and malignant evolution of OLP and might be a potential predictive biomarker for OLP [9].…”

Section: Fam3b Genementioning

confidence: 99%

Oral Lichen Planus Genetics Update

Albu

Bencze

Dragomirescu

et al. 2022

EJDENT

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“…keratin-forming cells replace CD8 + T cells in the major tissue, which is activated directly by the major histocompatibility complex (MHC)-1 on keratinocytes or indirectly by antigen-presenting [ 10 ]. OLP rarely regresses spontaneously and is classified as a potentially malignant disease by the World Health Organization[ 11 ]. Therefore, exploring the malignant mechanism of OLP to OSCC is crucial for early diagnosis of OSCC and for providing more effective therapeutic measures.…”

Section: Introductionmentioning

confidence: 99%

CD8 + T-cell marker genes reveal different immune subtypes of oral lichen planus by integrating single-cell RNA-seq and bulk RNA-sequencing

et al. 2023

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Background Oral lichen planus (OLP) is a local autoimmune disease induced by T-cell dysfunction that frequently affects middle-aged or elderly people, with a higher prevalence in women. CD8 + T cells, also known as killer T cells, play an important role in the progression and persistence of OLP. In order to identify different OLP subtypes associated with CD8 + T cell pathogenesis, consensus clustering was used. Methods In this study, we preprocessed and downscaled the OLP single-cell dataset GSE211630 cohort downloaded from Gene Expression Omnibus (GEO) to finally obtain the marker genes of CD8 + T cells. Based on the expression of marker genes, we classified OLP patients into CMGs subtypes using unsupervised clustering analysis. The gene expression profiles were analyzed by WGCNA using the “WGCNA” R package based on the clinical disease traits and typing results, and 108 CD8 + T-cell related OLP pathogenicity-related genes were obtained from the intersection. Patients were once again classified into gene subtypes based on intersection gene expression using unsupervised clustering analysis. Results After obtaining the intersecting genes of CD8 + T cells related to pathogenesis, OLP patients can be precisely classified into two different subtypes based on unsupervised clustering analysis, and subtype B has better immune infiltration results, providing clinicians with a reference for personalized treatment. Conclusions Classification of OLP into different subtypes improve our current understanding of the underlying pathogenesis of OLP and provides new insights for future studies.

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