Familial Aggregation and Childhood Blood Pressure

Wang, Xiaoling; Xu, Xiaojing; Su, Shaoyong; Snieder, Harold

doi:10.1007/s11906-014-0509-x

Cited by 18 publications

(16 citation statements)

References 70 publications

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“…The finding that BMI and FHH were associated with hypertension is consistent with previous cross-sectional and longitudinal studies [7–9, 11–15, 17]. After adjustment for all of the behavioural risk factors in our study, ORs for hypertension in Han and Yugur people with overweight (or obesity) and a FHH remained significant (Table 3).…”

Section: Discussionsupporting

confidence: 91%

“…The interactions between shared genes and environments lead to the aggregation of blood pressure within a family and result in physiological and biochemical processes that contribute to the increase of blood pressure [13]. It is estimated that 30% to 60% of the interindividual variation of blood pressure can be explained by genetic factors [9, 11, 14].…”

Section: Introductionmentioning

confidence: 99%

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The Additive Interaction between Body Mass Index and Hypertension Family History in Han and Yugur: The China National Health Survey (CNHS)

Zhao

Pan

et al. 2019

International Journal of Hypertension

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Objective. To estimate the additive interaction of body mass index (BMI) and family history of hypertension (FHH) on hypertension and explore whether the interaction could be influenced by behavioural risk factors. Methods. The cross-sectional data on 5791 participants were from the China National Health Survey in Gansu province in 2016. We assessed the additive interaction by calculating the relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP), and the synergy index (SI). Results. ORs for hypertension were highest in Han (13.52, 95% CI: 9.45 to 19.34) and Yugur (13.85, 95% CI: 8.48 to 22.63) with the combination of obesity and FHH. The interaction of BMI and FHH was significant in Han people, with the RERI, AP, and SI and their 95% CIs being 2.48 (1.13 to 3.82), 0.33 (0.19 to 0.47), and 1.61 (1.26 to 2.07) for overweight and FHH and 6.32 (1.91 to 10.73), 0.47 (0.27 to 0.67), and 2.02 (1.33 to 3.07) for obesity and FHH, respectively. The interaction of BMI and FHH was not significant in Yugur people. Adjustment for behavioural risk factors had little influence on the interactions, and risks of hypertension remained increased. Conclusions. BMI and FHH were associated with hypertension, and the interaction of BMI and FHH on hypertension was significant in Han but not in Yugur people. Behavioural risk factors had little influence on the associations and interactions. The exacerbation of hypertension risks by overweight or obesity in hypertension families deserves attention in weight control and community care.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The Additive Interaction between Body Mass Index and Hypertension Family History in Han and Yugur: The China National Health Survey (CNHS)

Zhao

Pan

et al. 2019

International Journal of Hypertension

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“…Family and twin studies have observed that the link between either of these two factors and BP can be partly attributed to a common set of genetic factors [15]. A GRS based on obesity susceptibility loci was associated with childhood BP and even explained a greater proportion of the variation in BP at certain ages than the BP 29-SNP GRS itself [9].…”

Section: Improving Bp Prediction Using Gwas and Ewas Findings Of Bmentioning

confidence: 99%

Assessing genetic risk of hypertension at an early age: future research directions

Wang

Snieder

2017

Expert Review of Cardiovascular Therapy

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“…For these reasons, it is important to know if pre-pregnancy risk in parents is transmitted specifically through pregnancy to infant offspring, or whether such transmission is a mere reflection of shared familial traits and lifestyles. 10 The aim of our study was to investigate whether there is an association between parental pre-pregnancy BMI and offspring’s BP during the first year of life, and if so from which time period this association is detectable.…”

Section: Introductionmentioning

confidence: 99%

Pre-pregnancy parental BMI and offspring blood pressure in infancy

Jansen

Dalmeijer

Saldi

et al. 2019

European Journal of Preventive Cardiology

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Aims A growing body of evidence suggests that a higher maternal pre-pregnancy body mass index results in higher offspring’s blood pressure, but there is inconsistency about the impact of father’s body mass index. Furthermore, evidence is limited with regard to low and middle income countries. We aimed to determine the association between parental pre-pregnancy body mass index and offspring’s blood pressure during the first year of life. Methods In 587 infants of the BReastfeeding Attitude and Volume Optimization (BRAVO) trial systolic and diastolic blood pressure were measured twice at the right leg in a supine position, using an automatic oscillometric device at day 7, month 1, 2, 4, 6, 9 and 12. Parental pre-pregnancy body mass index was based on self-reported weight and height. Linear mixed models were performed to investigate the associations between parental pre-pregnancy body mass index and offspring blood pressure patterns. Results Each unit increase in maternal body mass index was associated with 0.24 mmHg (95% confidence interval 0.05; 0.44) and 0.13 mmHg (0.01; 0.25) higher offspring’s mean systolic and diastolic blood pressure, respectively, during the first year of life. A higher offspring blood pressure with increased maternal pre-pregnancy body mass index was seen at birth and remained higher during the first year of life. The association with systolic blood pressure remained similar after including birth size and offspring’s weight and height over time. The association with diastolic blood pressure attenuated slightly to a non-significant result after including these variables. Paternal body mass index was not associated with offspring’s blood pressure. Conclusion Higher maternal pre-pregnancy body mass index, but not paternal pre-pregnancy body mass index, is associated with higher offspring blood pressure already from birth onwards.

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Familial Aggregation and Childhood Blood Pressure

Cited by 18 publications

References 70 publications

The Additive Interaction between Body Mass Index and Hypertension Family History in Han and Yugur: The China National Health Survey (CNHS)

The Additive Interaction between Body Mass Index and Hypertension Family History in Han and Yugur: The China National Health Survey (CNHS)

Assessing genetic risk of hypertension at an early age: future research directions

Pre-pregnancy parental BMI and offspring blood pressure in infancy

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