Familial aggregation and excess maternal transmission of type 2 diabetes in Tunisia

Arfa, Imen; Abid, Abdelmajid; Malouche, Dhafer; Alaya, Nissaf Ben; Azegue, Théophile Roland; Mannai, Imen; Zorgati, Mohamed Majdi; Rayana, Mohamed Chiheb Ben; Ammar, Slim Ben; Blousa-Chabchoub, S.; Romdhane, Habiba Ben; Zouari, B.; Dellagi, Mohamed Koussay; Abdelhak, Sonia

doi:10.1136/pgmj.2006.053744

Cited by 32 publications

(26 citation statements)

References 27 publications

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“…This suggests an excess maternal transmission. The familial aggregation of type 2 diabetes was confirmed in various populations [73,74], although the maternal effect was not univocally observed [75]. The pattern of segregation in families with type 2 diabetes is consistent with a complex, multifactorial inheritance.…”

Section: Type 2 Diabetes As a Genetic Diseasesupporting

confidence: 61%

Genes, Environment, and Interactions in Prevention of Type 2 Diabetes: A Focus on Physical Activity and Lifestyle Changes

Qi¹,

Hu²,

Hu³

2008

CMM

125

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Type 2 diabetes is one of the fastest growing public health problems worldwide. Both environmental (e.g. physical activity, obesity, and diet) and genetic factors are involved in the development of type 2 diabetes. The associations between physical activity and diabetes risk have been assessed by a number of prospective studies and clinical trials. The results from these studies consistently indicate that the regular physical activity during occupation, commuting, leisure time or daily life reduces the risk of type 2 diabetes by 15-60%; and lifestyle intervention, including counselling for physical activity, nutrition, and body weight, can reduce the risk of type 2 diabetes by 40-60% among adults with impaired glucose tolerance and by about 20% among general individuals. In the past decade, studies using traditional linkage analysis and candidate-gene association approach have found dozens of genes harboring common variants that were related to the common-form type 2 diabetes. However, most reported associations are lack of reproducibility, except TCF7L2, PPARG, CAPN10, and KCNJ11. Since 2007, seven genome-wide association (GWA) studies emerged to generate a list of new diabetes genes. The genetic effects are largely of moderate size. These findings provide novel insight into the diabetes etiology and pave new avenue for predicting the disease risk using genetic information. In addition, data especially those from intervention trials display preliminary but promising evidence that the genetic variants might interact with physical activity in predisposing to type 2 diabetes. The gene-environment interactions merit extensive exploration in large, prospective studies.

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Section: Type 2 Diabetes As a Genetic Diseasesupporting

confidence: 61%

Genes, Environment, and Interactions in Prevention of Type 2 Diabetes: A Focus on Physical Activity and Lifestyle Changes

Qi¹,

Hu²,

Hu³

2008

CMM

125

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show abstract

“…Mexican Americans, Pima Indians, gypsies of southern Slovakia, African Americans, etc. This feature has been reported in cases of isolated ethnic groups [7][8][9][10][11]and among underprivileged groups in developed countries [12]. NsiIpolymorphism at exon 8 of INSR gene has been associated with arterial hypertension [13].…”

Section: Introductionmentioning

confidence: 69%

ScreeningCodon 233, 234 and 276 Polymorphisms in Exon 3 ofInsulin Receptor Gene in Type 2 Diabetes Mellitus Patients ofKashmir Valley

Hameed¹

2012

IOSJPBS

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“…However, the prevalence of familial aggregation of T2D was higher among the Omani population than that reported among other populations. 10,11,13,26,27 Consanguineous marriages in Oman are about half that of all marriages, 23,24 and there is strong evidence that genetic factors play an important role in the pathogenesis of T2D. 25 Few studies were conducted among Arabs to investigate the family clustering of diabetes, despite high consanguineous marriages.…”

Section: Discussionmentioning

confidence: 98%

Familial Clustering of Type 2 Diabetes among Omanis

Al-Sinani¹,

Al-Shafaee²,

Al-Mamari³

et al. 2014

Oman Med J

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The findings of this study confirm familial aggregation of diabetes among the Omani population. Compared to other populations, familial aggregation of type 2 diabetes mellitus among Omanis is relatively very high, and is perhaps due to the very high degree of consanguinity among Omanis. Since almost everyone seems to have a genetic predisposition to diabetes, the dramatic lifestyle changes over the past 25 years, could tip the population into an epidemic of type 2 diabetes mellitus.

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Familial aggregation and excess maternal transmission of type 2 diabetes in Tunisia

Abstract: These results suggest familial aggregation and excess maternal transmission of type 2 diabetes in the Tunisian studied population.

Cited by 32 publications

References 27 publications

Genes, Environment, and Interactions in Prevention of Type 2 Diabetes: A Focus on Physical Activity and Lifestyle Changes

Genes, Environment, and Interactions in Prevention of Type 2 Diabetes: A Focus on Physical Activity and Lifestyle Changes

ScreeningCodon 233, 234 and 276 Polymorphisms in Exon 3 ofInsulin Receptor Gene in Type 2 Diabetes Mellitus Patients ofKashmir Valley

Familial Clustering of Type 2 Diabetes among Omanis

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