Familial aggregation of MATRICS Consensus Cognitive Battery scores in a large sample of outpatients with schizophrenia and their unaffected relatives

Mucci, Armida; Galderisi, Silvana; Green, M. F.; Nuechterlein, Keith H.; Rucci, Paola; Gibertoni, Dino; Rossi, Alessandro; Rocca, Paola; Bertolino, Alessandro; Bucci, Paola; Hellemann, Gerhard; Spisto, Myriam; Palumbo, Domenico; Aguglia, Eugenio; Amodeo, Giovanni; Amore, Mario; Bellomo, Antonello; Brugnoli, Roberto; Carpiniello, Bernardo; Dell’Osso, Liliana; Fabio, Fabio Di; Giannantonio, Massimo Di; Lorenzo, Giorgio Di; Marchesi, Carlo; Monteleone, Palmiero; Montemagni, Cristiana; Oldani, Lucio; Romano, Raffaella; Roncone, Rita; Stratta, Paolo; Tenconi, Elena; Vita, Antonio; Zeppegno, Patrizia; Maj, Mario

doi:10.1017/s0033291717002902

Cited by 46 publications

(43 citation statements)

References 62 publications

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“…The exclusive involvement of the academic domain in relatives, already reported by other authors (4,5), could be related to a mild cognitive dysfunction that has been described by several authors (68)(69)(70)(71)(72)(73) and found in the sample of relatives recruited in the present multicenter study (63,74).…”

Section: Discussionsupporting

confidence: 75%

“…Data analysis. Co-norming and standardization of the Italian MCCB test scores was carried out as described in Kern et al (55,63). For cognitive domains including more than one measure, that is working memory and speed of processing, the summary score for the domain was calculated by summing the scores of the tests included in that domain and then standardizing the sum to a Tscore.…”

Section: Assessmentsmentioning

confidence: 99%

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Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

Bucci

Galderisi

Mucci

et al. 2018

Acta Psychiatr Scand

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Section: Discussionsupporting

confidence: 75%

Section: Assessmentsmentioning

confidence: 99%

Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

Bucci

Galderisi

Mucci

et al. 2018

Acta Psychiatr Scand

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“…However, there may be intercultural differences in social processes and it would be interesting to examine these intercultural differences in social cognitive processes in patients with schizophrenia. Also, environmental factors [41,42], dietary influence [43,44] or stress-induced lifestyle condition may influence brain function and future studies may want to investigate this.…”

Section: Discussionmentioning

confidence: 99%

Neural Correlates of Emotional Ambiguity in Patients with Schizophrenia – Relationship with Expressive Deficits

Lange¹,

Bais²,

Renken³

et al. 2018

Neuropsychiatry

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ObjectiveNegative symptoms can be grouped into two factors, expressive deficits and social-emotional withdrawal. We aimed to examine the neural correlates of the two negative symptom factors during a social cognition task, which measures emotional ambiguity in a social context by presenting an array of faces with varying degrees of consistency in emotional expressions. MethodsPatients with schizophrenia (N=38) and healthy controls (N=20) performed a social cognition task during fMRI that probed both affect and ambiguity. Differences in brain activation between the healthy controls and patients were non-parametrically tested. Subsequently, the expressive deficits and social-emotional withdrawal factors were regressed against task-related brain activation. ResultsSeverity of expressive deficits was negatively correlated with activation of the ventromedial prefrontal cortex when comparing ambiguous emotional decisions to ambiguous gender decisions. During emotional ambiguity, severity of expressive deficits was negatively correlated with activation in thalamic, prefrontal, precentral, parietal and temporal brain areas. No associations between social-emotional withdrawal and brain activation were observed. ConclusionHypoactivation of the fronto-thalamic circuitry during ambiguous social appraisal may imply a reduced action readiness in social situations, underlying expressive deficits but not social-emotional withdrawal. The findings provide further evidence for different neurobiological bases of the two factors of negative symptoms.

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“…The components of mental health proposed by the authors are identified on the basis of a wide literature. Cognitive and social skills impact on all aspect of everyday life [16], and are considered to be impaired in sev-eral mental disorders ( [17][18][19]. The ability to recognize, express and modulate one's own emotions is also related both to mental health and to mental disorders [20].…”

Section: Searching For Normative Criteriamentioning

confidence: 99%

Controversial issues in current definitions of mental health

Cyranka¹

2020

Arch Psych Psych

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The concept of mental health is still widely discussed among philosophers and scientists. The emphasis on positive emotions and functional aspects of the World Health Organization definition has sometimes been called into question. This paper will focus on recently proposed mental health definitions, and in particular on mental health normative criteria involved in each of them. The criteria are divided in two broad categories: biomedical and cultural criteria. Strengths and weaknesses of each definition are illustrated in order to highlight research needs likely to support further progress. mental health, well-being, normative criteria, determinants of health

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Familial aggregation of MATRICS Consensus Cognitive Battery scores in a large sample of outpatients with schizophrenia and their unaffected relatives

Cited by 46 publications

References 62 publications

Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

Neural Correlates of Emotional Ambiguity in Patients with Schizophrenia – Relationship with Expressive Deficits

Controversial issues in current definitions of mental health

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