Familial aggregation of Parkinson's disease in a Finnish population

Autere, Jaana; Moilanen, Jukka S.; Myllylä, Vilho V.; Majamaa, Kari

doi:10.1136/jnnp.69.1.107

Cited by 42 publications

(40 citation statements)

References 22 publications

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“…The relative risk (RR) of PD when having a firstdegree relative with PD compared to having no first-degree relative with PD in these studies ranged between 1.6 and 10.4, although one study reported an odds ratio (OR) of 41.7 [147]. In general, population-based studies [155][156][157][158][159][160][161][162][163] reported lower RRs, with a range between 1.5 and 7.5. A study that included both a clinic-based sample and a population-based sample [161] reported a higher RR estimate together with lower age of PD onset in the clinic-based sample than in the population-based sample, indicating that the type of sampling strategy influences results.…”

Section: Family Studiesmentioning

confidence: 97%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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Section: Family Studiesmentioning

confidence: 97%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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“…However, some familial clusters have been identified with apparent Mendelian inheritance patterns. It is known that offspring of an affected parent have a two-to three-fold risk of also being affected with PD compared with population norms (Autere et al 2000;Sveinbjornsdottir et al 2000;Sellbach et al 2006). In recent years, a genetic basis for the disease has been shown particularly in patients with young age of onset.…”

Section: Introductionmentioning

confidence: 99%

Knowledge and attitudes towards genetic testing in those affected with Parkinson’s disease

Scuffham

McInerny-Leo

et al. 2013

J Community Genet

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Advances in genetic tests provide valuable information for clinicians and patients around risks and inheritance of Parkinson's Disease (PD); however, questions arise whether those affected or at risk of PD will want genetic testing, particularly given that there are no preventive or diseasemodifying therapies currently available. This study sought to determine knowledge and attitudes toward genetic testing for those affected with PD. A cross-sectional study was undertaken using a standardized questionnaire with six multi-choice genetic knowledge and 17 multi-choice attitude items. Participants were selected from a registry of people affected with PD living in Queensland, Australia. Half of the selected index cases had a family history of PD. Ordinal regression was used to evaluate the association between support for genetic testing and demographic, knowledge, and other attitudinal factors. The level of genetic knowledge was relatively low (37 % correct responses). The vast majority supported diagnostic testing (97 %) and 90 % would undertake a genetic test themselves. Support for predictive was lower (78 %) and prenatal genetic testing had the least support (58 %). Benefits of testing were identified as the ability to know the child's risk, seek therapies, and helping science with finding a cure. Concerns about genetic testing included potential emotional reactions and test accuracy. Genetic knowledge was not significantly associated with attitudes towards genetic testing. Patients with PD have strong interest in genetic testing for themselves with support for diagnostic testing but less support for predictive and prenatal testing. Genetic knowledge was unrelated to testing attitudes.

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“…By contrast, such relative risks have been estimated for many other neurological disorders with a genetic component (eg, Alzheimers' disease, amyotrophic lateral sclerosis, and Parkinson's disease). [21][22][23] These relative risks help in defining quantitatively the genetic contribution to these diseases. In addition, there has been little attempt to explore systematically the impairments resulting from tremor among affected relatives.…”

mentioning

confidence: 99%

Risk of tremor and impairment from tremor in relatives of patients with essential tremor: A community-based family study

et al. 2001

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Essential tremor (ET) is a common condition that is present in as many as 23% of elderly individuals. Our objective was to determine the risk of ET and to study the impairment resulting from ET among relatives of ET cases compared to relatives of controls. ET cases and matched controls from the Washington Heights-Inwood community, New York, and their first- and second-degree relatives underwent a standardized tremor examination. The risk of having ET in relatives of cases vs relatives of controls was compared using Cox proportional hazards models. Five hundred ninety-one subjects were examined (59 ET cases, 72 controls, 234 case relatives, and 226 control relatives). ET was present in 25 (22.5%) of the 111 first-degree relatives of cases compared to 6 (5.6%) of 107 first-degree relatives of controls [relative risk (RR) = 4.67, 95% confidence interval (CI) = 1.90-11.49, p = 0.0008]. RRs were higher in relatives of cases with onset < or =50 years than in those with later onset (RR = 10.38 vs 4.82). Sixteen (64%) of twenty-five affected first-degree case relatives exhibited moderate tremor while performing tasks such as writing, drinking, or pouring. Relatives of ET patients are five times more likely to develop the disease than are members of the population and ten times more likely if the proband's tremor began at an early age. The majority of the affected relatives can expect to experience impairment resulting from tremor.

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Familial aggregation of Parkinson's disease in a Finnish population

Cited by 42 publications

References 22 publications

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Knowledge and attitudes towards genetic testing in those affected with Parkinson’s disease

Risk of tremor and impairment from tremor in relatives of patients with essential tremor: A community-based family study

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