Familial and Hereditary Syndromes in Renal Cell Cancer

Ball, Mark W.; Pinto, Peter A.

doi:10.1007/978-3-030-24378-4_3

Cited by 2 publications

(8 citation statements)

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“…Researchers postulate that as many as 16 genes may be implicated in the various forms of renal malignancies, including RCC 4,6,12-14. Most RCCs are clear cell RCC (ccRCC) , sometimes referred to as conventional RCC.…”

Section: Genetic Alterations In Rccmentioning

confidence: 99%

“…Most RCCs are clear cell RCC (ccRCC) , sometimes referred to as conventional RCC. These are genetically linked to mutations on the short arm of chromosome 3 (3p) 4,6,12-14…”

Section: Genetic Alterations In Rccmentioning

confidence: 99%

“…The primary gene implicated in ccRCC is the von Hippel-Lindau (VHL) gene, known as pVHL 4,6,12-14. VHL helps to control cell growth and division in all body tissues.…”

Section: Genetic Alterations In Rccmentioning

confidence: 99%

“…VHL helps to control cell growth and division in all body tissues. pVHL is a suppressor protein that undergoes mutation leading to an increase in insulin-like growth factor-1, upregulation of hypoxia-inducible factor and vascular endothelial growth factor (VEGF), creation of VEGF receptors, and angiogenesis, which results in tumor formation 4,6,12-14…”

Section: Genetic Alterations In Rccmentioning

confidence: 99%

“…A pathogenic variant in the VHL gene is linked to VHL disease , which is an autosomal dominant syndrome that predisposes a person to ccRCC in one or both kidneys, renal cysts, pheochromocytoma, and tumors in the brain, spinal cord, retina, pancreas, adrenal glands, and endolymphatic sacs. The syndrome occurs in 2% to 4% of patients with ccRCC, and more frequently in younger men and women 4,6,12-15…”

Section: Genetic Alterations In Rccmentioning

confidence: 99%

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Renal cell carcinoma, part 1

Pullen

2021

Nursing

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July l Nursing2021 l 35 THE AUTHOR'S journey with chronic illness began in 1998 at age 40, with a diagnosis of systemic lupus erythematosus (SLE). SLE and medications used to treat the disease increase the risk for infection. Several years ago, computed tomography (CT) of the chest, performed to confirm a diagnosis of right lower lobe pneumonia, revealed a 3-cm mass. A diagnosis of renal cell carcinoma (RCC) followed, along with a growing acquaintance with this disease. A partial nephrectomy was performed to remove the cancer, enabling a cancer-free life for the past 2 years.This article, the first of a three-part series on RCC, will address the incidence and epidemiology of RCC along with its genetic alterations, risk factors, histologic characteristics, and imaging characteristics. The subsequent articles will address treatment options and take a more detailed look at nursing interventions. Incidence and epidemiologyThe incidence of renal malignancy is 6 per 100,000 men and 3 per 100,000 women. Of all malignancies globally, it ranks 9th in men and 14th in women. 1 In the US, the incidence is 21 per 100,000 men and 11 per 100,000 women, representing the sixth and eighth most common malignancies in men and women, respectively. 1,2 According to the American Cancer Society, about 76,080 new cases of kidney cancer (48,780 in men and 27,300 in women) will be diagnosed in 2021, and about 13,780 people will die from this disease. 3 Sometimes referred to as renal cell adenocarcinoma or hypernephroma, RCC accounts for at least 85% of all renal malignancies and occurs more often than benign renal masses. 3 The incidence of RCC is highest in North America, Australia, and Europe, and lowest in India, Japan, Africa, and China. 1,2,4 Morbidity and mortality associated with RCC is higher for Black Americans, Native Americans, and Hispanics than for White patients, which is likely related to socioeconomic stressors, disparities in access to healthcare, and comorbidities. 1,4,5 Pathophysiology RCC encompasses a group of malignancies that originate in the Abstract: Renal cell carcinoma (RCC) encompasses a group of malignancies that originate in the epithelium of the renal cortex, most often in the upper pole of the kidney. This article, the first of a three-part series on RCC, addresses the incidence and epidemiology of RCC along with its genetic alterations, risk factors, histologic characteristics, and imaging characteristics.

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Section: Genetic Alterations In Rccmentioning

confidence: 99%

“…Most RCCs are clear cell RCC (ccRCC) , sometimes referred to as conventional RCC. These are genetically linked to mutations on the short arm of chromosome 3 (3p) 4,6,12-14…”

Section: Genetic Alterations In Rccmentioning

confidence: 99%

“…The primary gene implicated in ccRCC is the von Hippel-Lindau (VHL) gene, known as pVHL 4,6,12-14. VHL helps to control cell growth and division in all body tissues.…”

Section: Genetic Alterations In Rccmentioning

confidence: 99%

Section: Genetic Alterations In Rccmentioning

confidence: 99%

Section: Genetic Alterations In Rccmentioning

confidence: 99%

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