Familial associations between polycystic ovarian syndrome and common diseases

Moini, Ashraf; Eslami, Bita

doi:10.1007/s10815-009-9297-7

Cited by 34 publications

(20 citation statements)

References 22 publications

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“…It is more common in mother's side of the family. [8] Although most of the adverse health consequences associated with PCOS is substantial, most women are not aware of the risk, hence the need to intensify reproductive health education. There is also the need to screen and monitor patients with PCOS and their relations for adverse health conditions associated with PCOS pathology.…”

Section: Discussionmentioning

confidence: 99%

Familial trend in polycystic ovarian syndrome: Report of two cases

Joe-kechebelu¹,

Mbamara

Ikechebelu

2013

Ann Afr Med

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Polycystic ovarian syndrome (PCOS) is an endocrine disorder with a strong genetic component. The affected females present with anovulatory cycles, a spectrum of menstrual disorders, and features of androgen excess. We present the case of two sisters who were diagnosed with PCOS and have a family history of oligomenorrhoea in their grandmother and PCOS in their mother and sisters. They also have a family history of hypertension, diabetes mellitus, and breast mass which are known co-morbidities associated with PCOS. Both were managed successfully with ovulation induction using clomiphene citrate. PCOS could be familial as in our patients and further research is required to define the exact genetic pattern of inheritance.

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Section: Discussionmentioning

confidence: 99%

Familial trend in polycystic ovarian syndrome: Report of two cases

Joe-kechebelu¹,

Mbamara

Ikechebelu

2013

Ann Afr Med

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“…The diabetes risk score also comprises both modifiable and nonmodifiable DM2 risk factors including age, diet, exercise, and personal or family history of high blood pressure or glucose. Of these, obesity (38), abdominal obesity (39), and family history of DM2 (40) have been reported to be elevated in PCOS. Of note, we report that the diabetes risk score was still elevated for all PCOS despite younger ages for women with PCOS and similar family history of diabetes for all women.…”

Section: Discussionmentioning

confidence: 99%

Diabetes risk score in the diagnostic categories of polycystic ovary syndrome

Moran

Strauss

Teede

2011

Fertility and Sterility

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“…Kulshreshtha et al [14] obtained the same result; specifically, a paternal history of HT is more common among PCOS patients than controls, while a maternal history of HT did not confer an increased risk for PCOS. Moini et al [25] reported a significantly increased prevalence of maternal DM in the PCOS group than the control group, and a maternal history of DM was more predictive than a paternal history of DM. Moreover, mothers of women with PCOS had a higher HOMA-IR, an increased prevalence of MetS, and an elevated risk for CHD [26].…”

Section: Discussionmentioning

confidence: 97%

Paternal history of diabetes mellitus and hypertension affects the prevalence and phenotype of PCOS

Chen

Zhang

Zhao

et al. 2015

J Assist Reprod Genet

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Purpose The purpose of the present study is to determine if paternal or maternal history of diabetes mellitus (DM) and hypertension (HT) contributes to the prevalence and phenotype of polycystic ovary syndrome (PCOS). Methods We performed an epidemiologic study about PCOS from four districts in Beijing, China, between 2008 and 2009. Parental histories of DM and HT were collected, and the basic characteristics and serum indices of 123 PCOS patients and 718 non-PCOS controls were tested. Results The prevalence of a parental history of DM and HT was significantly higher in PCOS patients than non-PCOS women (17.1 % vs. 9.2 % and 42.3 % vs. 26.0 %, P<0.05, respectively). When paternal history was separated from maternal history, only a paternal history of DM and HT reached statistical significance between PCOS and non-PCOS patients (odds ratio (OR)=3.42, 95 % confidence interval (CI)=1.69-6.91; OR=2.50, 95 % CI=1.58-3.93, respectively). A paternal history of both DM and HT was significantly associated with sex hormone-binding globulin, fasting plasma glucose, and fasting insulin levels, the free androgen index, and the homeostatic model assessment-insulin resistance in PCOS patients (P<0.05 for all). There was no independent association between maternal history and the clinical or biochemical phenotype of PCOS. Conclusions PCOS patients with a positive paternal history of both DM and HT have an adverse endocrine and metabolic profile. A paternal history of DM and HT poses a risk to PCOS.

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Familial associations between polycystic ovarian syndrome and common diseases

Cited by 34 publications

References 22 publications

Familial trend in polycystic ovarian syndrome: Report of two cases

Familial trend in polycystic ovarian syndrome: Report of two cases

Diabetes risk score in the diagnostic categories of polycystic ovary syndrome

Paternal history of diabetes mellitus and hypertension affects the prevalence and phenotype of PCOS

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