Familial Atrial Tachyarrhythmia With Short PR Interval

Brodsky, Michael A.; Wu, Delon; Denes, Pablo; Rosen, Kenneth M.

doi:10.1001/archinte.1977.03630140021008

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Some reports published in the 1970s describe familial occurrence of adult onset conduction disturbances, sinus bradycardia, atrial tachyarrhythmias, sudden cardiac death, myocardial hypertrophy, short PR interval, and intraventricular conduction disturbances in the absence of the WPW syndrome 21,22 . Genetic evaluation was not available at that time but the clinical picture described is consistent with our observations in the affected individuals reported in our study.…”

Section: Discussionsupporting

confidence: 91%

Familial Pseudo‐Wolff‐Parkinson‐White Syndrome

Sternick

Oliva

Magalhães

et al. 2006

Cardiovasc electrophysiol

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Section: Discussionsupporting

confidence: 91%

Familial Pseudo‐Wolff‐Parkinson‐White Syndrome

Sternick

Oliva

Magalhães

et al. 2006

Cardiovasc electrophysiol

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“…There are, however, only 2 reports of a familial incidence of the Lown-Ganong-Levine syndrome. Lown et al (1952) mentioned a mother and son with the disorder and recently Brodsky et al (1977) described 6 members of a family with the surface electrocardiographic features of the Lown-Ganong-Levine syndrome though the proband was studied by intracardiac electrical stimulation and found not to have the features of an atrioventricular nodal bypass tract. The present report is the first of identical twins each with electrophysiological evidence of an atrioventricular nodal bypass tract.…”

Section: Discussionmentioning

confidence: 99%

Identical twins with differing forms of ventricular pre-excitation.

Bennett¹,

Gribbin²,

Birkhead³

1978

Heart

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SUMMARY Identical 10-year-old twins, both with electrocardiograms showing a short PR interval and a normal QRS complex but with dramatically different electrophysiological characteristics, are described.One twin experienced episodes of rapid palpitation and on one occasion was resuscitated from ventricular fibrillation. An intracardiac electrophysiological study confirmed the presence of an atrioventricular nodal bypass tract and in addition revealed the presence of an accessory atrioventricular pathway, thus demonstrating that the patient had both the Lown-Ganong-Levine and Wolff-ParkinsonWhite syndromes. Re-entry tachycardia and atrial fibrillation, with a very rapid ventricular rate, were precipitated. After treatment with amiodarone, the patient became asymptomatic and a repeat study showed that the features of the atrioventricular nodal bypass tract were no longer present and though re-entry tachycardias using the accessory atrioventricular pathway could still be induced, their rates were slower than before treatment.The other twin, in spite of an identical surface electrocardiogram, was asymptomatic. An electrophysiological study showed the features of an atrioventricular nodal bypass tract but there was no evidence of additional atrioventricular accessory connections and a tachycardia could not be induced.The Lown-Ganong-Levine syndrome (1952) and the Wolff-Parkinson-White syndrome (1930) are both types of ventricular pre-excitation. The former results from an atrioventricular nodal bypass tract and the latter from an accessory atrioventricular pathway (Wellens, 1975).The purpose of this paper is to describe identical twins with differing forms of pre-excitation. Both have the surface and intracardiac electrophysiological features of an atrioventricular nodal bypass tract (Lown-Ganong-Levine syndrome). One twin has in addition, the features of a concealed accessory atrioventricular pathway (Wolff-Parkinson-White syndrome). In cases of ventricular pre-excitation, accessory atrioventricular connections of more than one type are sometimes present but this is only the second report of a patient with the surface electrocardiogram of the Lown-Ganong-Levine syndrome in whom an accessory atrioventricular pathway was disclosed by an intracardiac electrophysiological study (Massumi and Vera, 1971;Spurrell et al., 1973;Gallagher et al., 1976), and it is the first report of identical twins with proved atrioventricular nodal bypass tracts. The patients are identical, male, 10-year-old twins. They were born after an uncomplicated pregnancy and delivery but twin A was noticed to have an apical systolic murmur in infancy and this has persisted. Twin A had experienced frequent, brief episodes of rapid palpitation for some months before the incident which brought about his admission to hospital. At that time his father, a general practitioner, found that he had a heart rate of over 300 per minute; carotid sinus massage was ineffective and 2 hours later, after admission, an electrocardiogram showed atrial fibrillation with ...

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