Familial bilateral carpal tunnel syndrome.

Is there a familial carpal tunnel syndrome? An evaluation and literature review

“…HLA typing of two affected individuals and their offspring found no conclusive results. 18 Red cell and serum markers were used in a linkage analysis in an attempt to map the FCTS gene, but no evidence for linkage was obtained. 21 Further analysis with polymerase chain reaction (PCR)-based markers is needed.…”

Primary Familial Carpal Tunnel Syndrome with Long-term Followup: A Study of Two Families and Review of the Literature

“…Mochizuki also identified a preponderance of HLA-AW33 and HLA-B12 antigens in a family affected by FCTS. However, subsequent investigations into links between FCTS and specific HLA types have not confirmed their association, nor have they identified other reliable disease markers [11,18]. Genetic linkage analysis between FCTS and polymorphic blood markers has also proven unfruitful [28,32].…”

“…Phalen's test was positive at the most small FCTS case series have been published. However, essentially all of these studies lack outcome measures beyond five years postoperatively [2,4,[8][9][10][11][12]. In addition, there are few reports noting outcomes in children afflicted with this condition.…”

Carpal Tunnel Syndrome in a 28-Month-Old Child

“…The majority of cases in children below the age of 10 years are related to metabolic disorders; mucopolysaccharidosis and mucolipidosis account for 77% of cases [7, 8]. Other etiologies of carpal tunnel syndrome in children are familial [9, 10], deformities of the hand [11], hemangioma of the median nerve [12], trauma [13], primary non-Hodgkin’s lymphoma [14], iatrogenic [15], Schwartz-Jampel syndrome [16], Weil-Marchesani syndrome [17], infections [18], rubella [19]and hormonal [20], among others.…”