Familial Carcinoma of the Submandibular Gland: A Case Report and an Epidemiologic Review

Newman, Anita; Calcaterra, Thomas C.; Bhuta, Sunita

doi:10.1001/archotol.1981.00790390035010

Cited by 15 publications

(1 citation statement)

References 18 publications

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“…Reported familial cases of salivary gland neoplasms are few and include pleomorphic adenoma, Warthin tumor, submandibular gland carcinoma, MALT lymphoma, and acinic cell carcinoma (ACC). 9–13 In addition, two studies report familial clustering of ACC. 9,10 Five siblings in two families among Inuit in Greenland had familial SGC.…”

Section: Introductionmentioning

confidence: 99%

Familial Predisposition for Salivary Gland Cancer in Finland

Aro

Klockars

Leivo

et al. 2014

Clin Med Insights Ear Nose Throat

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BACKGROUNDSalivary gland cancer (SGC) accounts for 3–5% of head and neck malignancies, and register-based studies estimate the familial proportion to be 0.15%.OBJECTIVEWe studied familial predisposition for SGC in the genetically distinct Finnish population.PATIENTS AND METHODSWe sent a patient questionnaire to 161 Finnish SGC patients, 86 of whom responded.RESULTSA total of 76% of the patients reported having one or more relatives with cancer, 30% two or more, and 9% three or more but only one patient reported having a relative with SGC. Tracing the birthplaces of the SGC patients’ grandparents showed no regional clustering suggestive of a founder effect.CONCLUSIONSLack of familial SGC patients and the absence of a founder effect strongly suggest that familial predisposition for SGC is insignificant in the Finnish population. Various histological subtypes and the rarity of these neoplasms make it impossible to draw conclusions about site-specific association between SGC and other malignancies.

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Section: Introductionmentioning

confidence: 99%

Familial Predisposition for Salivary Gland Cancer in Finland

Aro

Klockars

Leivo

et al. 2014

Clin Med Insights Ear Nose Throat

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Familial clustering of salivary gland carcinoma in greenland

Merrick

Albeck

Nielsen

et al. 1986

Cancer

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Salivary gland carcinoma (SGC) occurs at an increased frequency in the Eskimo population. In Greenland the incidence of SGC is 4.5-fold higher for men and 9-fold higher for women as compared with European incidence. The increased incidence is caused by low-differentiated carcinoma. Unusual familial clustering of SGC is reported among two families (five siblings). Peculiar aspects of racial and geographical distribution and possible role of genetic and environmental factors in the etiology of this relatively uncommon tumor are briefly discussed with special emphasis on the recently detected association between the Eskimos' SGC and the Epstein-Barr virus.

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Speicheldrüsentumoren

Seifert

1996

Oralpathologie I

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Familial Carcinoma of the Submandibular Gland: A Case Report and an Epidemiologic Review

Cited by 15 publications

References 18 publications

Familial Predisposition for Salivary Gland Cancer in Finland

Familial Predisposition for Salivary Gland Cancer in Finland

Familial clustering of salivary gland carcinoma in greenland

Speicheldrüsentumoren

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