Familial cutaneous collagenoma. Report of cases

Henderson, Robert R.

doi:10.1001/archderm.98.1.23

Cited by 15 publications

(27 citation statements)

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“…Familial cutaneous collagenoma has been previously reported in three brothers with a clinical and histological presentation similar to our cases (Henderson et al, 1968). These patients also demonstrated multiple, asymptomatic skin nodules with a preferential location on the upper back.…”

Section: Discussionsupporting

confidence: 86%

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Familial cutaneous collagenoma: genetic studies on a family*

1979

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Familial cutaneous collagenoma is an inherited condition characterized by the presence of multiple dermal nodules symmetrically distributed on the trunk and upper arms. In this study, six patients, the proband, his four siblings and a niece, representing a kindred of fifty-two subjects, were examined for aymptomatic cutaneous nodules mainly on the back and chest. The individual lesions varying from a few millimetres to several centimetres in size, were indurated, and showed minimal epidermal changes. Histologically, the nodules were characterized by an excessive accumulation of dense, coarse collagen fibres in the dermis. The elastic fibres appeared diminished in number, and in some areas they were abnormally thin and fragmented. The lesions, therefore, were connective tissue naevi of the collagen type. On the basis of the family history and histological observations the patients were diagnosed as having familial cutaneous collagenoma. Examination of the family pedigree indicated that the dermal nodules in familial cutaneous collagenoma were inherited in an autosomal dominant pattern. It was also observed that the lesions had an onset at the age of 15 to 19 years, and their number increased significantly during pregnancy. It is conceivable that familial cutaneous collagenoma is an inherited condition whose expression may be under a hormonal control.

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Section: Discussionsupporting

confidence: 86%

“…Also, one of the cases reported by Henderson et al (1968) had idiopathic, progressive myocardiopathy with congestive heart failure and a left bundle branch block. In particular, the question of cardiac abnormalities encountered in some of our patients (see above) is of interest.…”

Section: Discussionmentioning

confidence: 99%

Familial cutaneous collagenoma: genetic studies on a family*

1979

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“…In 1 family, the nodules appeared between ages 15 to 19 years; in the other 2 families, the ages varied from the late teens to the 40s. 3,5,6 It has been suggested that FCC may be associated with an extracutaneous process because cardiac abnormalities have been encountered in some of the patients studied. 1,6 Histologically, the nodules are characterized by an excessive accumulation of dense, coarse collagen fibers in the dermis, with a diminished amount of elastic fibers that are abnormally thin or fragmented in some areas.…”

Section: Discussionmentioning

confidence: 99%

“…3,5,6 It has been suggested that FCC may be associated with an extracutaneous process because cardiac abnormalities have been encountered in some of the patients studied. 1,6 Histologically, the nodules are characterized by an excessive accumulation of dense, coarse collagen fibers in the dermis, with a diminished amount of elastic fibers that are abnormally thin or fragmented in some areas. 3,5 This decrease in elastin possibly represents a dilution phenomenon related to the excessive amount of collagen.…”

Section: Discussionmentioning

confidence: 99%

Development of collagenomas during pregnancy

McClung

Blumberg

Huttenbach

et al. 2005

Journal of the American Academy of Dermatology

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“…The histology of these lesions shows storing of dense, coarse collagen fibers in the dermis and a decrease in elastic fibers. In the literature, only 11 cases, belonging to three different families, have been reported so far 2–4 …”

Section: Discussionmentioning

confidence: 99%

Familial cutaneous collagenoma: report of an affected family

et al. 2005

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A 44‐year‐old white woman was admitted to our hospital for the investigation of many roundish, pale‐colored, nodular lesions of different sizes, ranging from a few millimeters to some centimeters, symmetrically grouped on the shoulders (Fig. 1), trunk, upper limbs, and abdomen. The lesions first appeared at 20 years of age on the upper chest around the clavicular region, and thereafter gradually increased on the trunk and upper limbs; they were completely asymptomatic, appearing on normal skin without a previous history of inflammation and/or trauma. No scarring or atrophy was evident. The smaller lesions exhibited a miliaria‐like shape, being evident in particular on stretching of the skin; the larger ones showed a firm‐elastic density, no adhesion to surrounding tissue, and deep localization in the skin. No hypopigmented macules or sebaceous adenoma‐like lesions were present. Skin biopsy of a nodular lesion from the right shoulder revealed a normal epidermis and a dermis filled with bundles of dense and coarse collagen fibers (Fig. 2). Elastic fibers appeared thin and decreased in number under Verhoeff–van Gieson stain (Fig. 3). A diagnosis of cutaneous collagenoma was proposed. Routine laboratory investigations were within the normal range. Chest and skeleton (hands, pelvis, and long bones) X‐ray, electrocardiogram, and echocardiogram showed no abnormality. 1 Nodular papules localized on the right shoulder 2 Histology of a lesion taken from the right shoulder. The picture demonstrates dense and coarse collagen bundles (hematoxylin and eosin stain; original magnification, × 200) 3 Elastic fibers are clearly diminished in number, thin, and fragmented (Verhoeff–van Gieson stain; original magnification, × 400) In order to evaluate a possible familial cutaneous collagenoma, the 19‐year‐old son of the patient was also examined. He had a 3‐month history of numerous, asymptomatic, skin‐colored nodules, ranging from 0.5 to 2 cm, on the upper back. Skin biopsy of a nodular lesion showed the same features as observed in the mother's biopsy. Routine blood and serum tests and X‐ray examinations were within normal limits. Electrocardiogram revealed an early R‐wave transition, and echocardiogram showed a left ventricular dilation with thickened aorta; aortic steno‐insufficiency was diagnosed under cardiologic examination. The diagnosis of familial collagenoma was confirmed, and similar cutaneous lesions were found in the mother's grandmother and aunt.

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Familial cutaneous collagenoma. Report of cases

Cited by 15 publications

References 0 publications

Familial cutaneous collagenoma: genetic studies on a family*

Familial cutaneous collagenoma: genetic studies on a family*

Development of collagenomas during pregnancy

Familial cutaneous collagenoma: report of an affected family

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