Familial desmoplastic trichoepithelioma

Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma?

“…Desmoplastic trichoepithelioma (DTE) is an uncommon neoplasm of follicular derivation first described by Brownstein and Shapiro in 1977 1 . Clinically, it often presents as an asymptomatic, solitary, slow‐growing, indurated lesion with an elevated annular border involving sun‐exposed areas, particularly the face, of young to middle‐aged women 2,3 . Both clinically and microscopically, it can resemble morpheaform/infiltrative basal cell carcinoma (mBCC) 2,3 .…”

“…Clinically, it often presents as an asymptomatic, solitary, slow‐growing, indurated lesion with an elevated annular border involving sun‐exposed areas, particularly the face, of young to middle‐aged women 2,3 . Both clinically and microscopically, it can resemble morpheaform/infiltrative basal cell carcinoma (mBCC) 2,3 . Histopathologically, the morpheaform and infiltrative variants of basal cell carcinoma are particularly challenging to differentiate from DTE, especially in the setting of a small biopsy specimen 2–4 .…”

Desmoplastic Trichoepithelioma: An Infrequent Entity not to be Missed: Report of Two Cases

“…The lesions were clinically misdiagnosed in most cases. Misdiagnosis included squamous cell carcinoma (SCC) , sebaceous hyperplasia , and BCC , as in our first case.…”

Familial desmoplastic trichoepithelioma: limitation of electronic database search and solutions

“…When we prepared our manuscript 3 and searched for relevant literature, we used the disease term “desmoplastic trichoepithelioma” for searching the MEDLINE because this entity is not a medical subject heading (MeSH). Shapiro's publication could not be identified because the plural form, “trichoepitheliomas”, was used in their title and abstract, where the MEDLINE would treat it as a different term.…”