Familial eruptive syringoma in a Nigerian girl

Ibekwe, Perpetua U.

doi:10.1111/ced.12766

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…En el diagnóstico diferencial de los siringomas se incluyen xantomas, quistes de millium, angiofibromas, verrugas planas, hiperplasias sebáceas, otros tumores anexiales, urticaria pigmentosa o liquen plano entre otros cuadros [1,2,4]. El estudio histopatológico muestra una proliferación dérmica de células epiteliales de citoplasma pálido eosinófilo, dispuestas en nidos o túbulos, rodeadas de un estroma fibroso y con una forma típica de "renacuajo" o "coma" [5,6]. Debido a la benignidad del cuadro y a la ausencia de síntomas asociados, el principal objetivo del tratamiento es estético, ya que en el caso de los SE pueden llegar a ser muy llamativos y afectar de forma importante la esfera psicosocial de los pacientes.…”

Section: Discussionunclassified

Dermatosis papular extensa en un paciente con síndrome de Down

González‐Ruiz¹

2019

Our Dermatol Online

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Syringomas are benign adnexal tumors deriving from eccrine sweat ducts, that affect 1% of general population. They present with a female predominance and associated with Down's syndrome. Syringomas are classified into four clinical variants, the localized form is the most frequent. Clinically, the appear as multiple, small, firm, skin-colored and asymptomatic papules, usually distributed in the periorbital area. Skin biopsy show benign proliferation of multiple eccrine ducts embedded in fibrotic stroma of the upper dermis. We present a case of a 20-year-old man with Down's syndrome with multiple papules resembling eruptive syringomas. We review reported clinical and histopathological findings of eruptive syringomas and discuss differential diagnosis as well as treatment options.

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Section: Discussionunclassified

Dermatosis papular extensa en un paciente con síndrome de Down

González‐Ruiz¹

2019

Our Dermatol Online

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“…Further, surgical therapies are ineffective due to the location of ES and the high risk of recurrence. 3 However, the pathophysiology of ES remains an enigma. ES has been described eccrine duct reactive hyperplasia in response to inflammation than as real neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Serum Proteomics Combined with Metabolomics Analysis Explore the Molecular Biological Characteristics of Eruptive Syringoma

Wang

Liu

Lei

et al. 2023

CCID

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Background: Eruptive syringoma (ES) is a clinical variant of the appendageal tumor syringoma. Around 75% of ES arise in the head or neck, which makes them unsightly. ES is common in patients with amyloidosis, diabetes, and Down's syndrome, suggesting that it may be associated with potential systemic effects. ES is a rare tumor with the unclear pathogenesis and no effective treatment. Methods: A PubMed search of ES was conducted. Plasma samples of patients with ES were acquired from the Department of Dermatology at Xi'an Jiaotong University's Second Affiliated Hospital. After removing highly abundant proteins, plasma samples were subjected to proteomics and metabolomics analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: LC-MS/MS revealed 71 differentially expressed proteins and 18 differentially abundant metabolites. The functional analysis highlighted the importance of complement binding, coagulation, secretory granules and vesicle lumen. Further, the study revealed 15 hub genes associated with FGG, GC, APOE, FGA, FGB, C4A, C3, CRP, C4B, FLNA, TAGLN2, ANXA5, MYL6, MYL12B, and TLN1 organized into three clusters. The seed genes in each cluster were GC, FLNA, and MYL6. In addition, glycol metabolism was associated with variable abundance of serum metabolites, which explains the relatively high rate of ES among diabetics. Conclusion:This study suggests that immunological inflammation and tumor glycol metabolism may play significant role in the pathophysiology of ES.

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Late-Onset Eruptive Clear Cell Syringoma: A Case Report and Literature Review

Eittidachachote,

Triyangkulsri,

Rutnin

et al. 2024

CCID

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Eruptive syringoma, a rare subtype of syringoma, is a benign adnexal tumor arising from the eccrine sweat glands. It is characterized by multiple asymptomatic, flat-topped, brown-pigmented papules. The disease typically occurs during adolescence and young adulthood. The clear cell variant of syringoma, which histologically features ductal epithelial cells with clear cytoplasm, is relatively rare, while eruptive clear cell syringoma is even more infrequent. In this report, we present a case of a 64-year-old Thai woman who developed multiple erythematous to brownish papules on her right cheek, which eventually spread to the periorbital region, face, neck, and chest over five years. The diagnosis of late-onset eruptive clear cell syringoma was made based on the patient’s clinical manifestations and confirmed by histopathological examination. Notably, the patient was found to have impaired fasting plasma glucose upon screening, highlighting the potential association between clear cell syringoma and glucose metabolism abnormalities. This case report emphasizes the importance of considering this diagnosis in elderly patients presenting with eruptive papular dermatoses and underscores the need for metabolic screening in affected individuals.

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Familial eruptive syringoma in a Nigerian girl

Cited by 3 publications

References 7 publications

Dermatosis papular extensa en un paciente con síndrome de Down

Dermatosis papular extensa en un paciente con síndrome de Down

Serum Proteomics Combined with Metabolomics Analysis Explore the Molecular Biological Characteristics of Eruptive Syringoma

Late-Onset Eruptive Clear Cell Syringoma: A Case Report and Literature Review

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