Familial follicular mucinosis: A case letter

Weir, Gina; Burns, Erin K.; Fraga, Garth; Aires, Daniel

doi:10.1016/j.jaad.2012.07.008

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…Weir et al described the paradox of FM: on one hand, younger patients present with benign and limited lesions carrying a favorable prognosis, and, on the other, older adults present with more severe lesions reminiscent of mycosis fungoides (MF). It may be difficult at times to make the distinction between a benign and a malignant process 6 . Leboit presented four different approaches in viewing FM.…”

Section: Pathogenesismentioning

confidence: 99%

“…It may be difficult at times to make the distinction between a benign and a malignant process. 6 Leboit presented four different approaches in viewing FM. In the first approach, FM is regarded as a benign lymphocytic neoplasm consisting of a self-limited proliferation of lymphocytes, which explains the presence of clonality in its infiltrate.…”

Section: Pathogenesismentioning

confidence: 99%

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Follicular mucinosis: a review

2020

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Follicular mucinosis (FM) is an epithelial reaction pattern characterized by follicular mucin accumulation. It has been described in association with various inflammatory and neoplastic cutaneous disorders. FM is generally divided into a primary benign idiopathic form and a secondary form usually occurring in association with cutaneous lymphomas (especially mycosis fungoides), among other entities. Distinction between the two forms can be challenging as they share many overlapping features and the lack of a single diagnostic tool to differentiate between the two. Making the distinction may require evaluating and correlating the clinical, histologic, immunohistochemical, and molecular studies together. Long‐term clinical follow‐up also remains very important. In this review, we describe the different entities associated with FM, its pathogenesis, and possible therapeutic options.

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Section: Pathogenesismentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Follicular mucinosis: a review

2020

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“…Schneider et al [66] reported HCQ use in 6 patients with idiopathic follicular mucinosis and found improvement in all patients without any relapse. However, use in pediatric patients has shown inconsistent results [67, 68].…”

Section: Other Forms Of Alopeciamentioning

confidence: 99%

Use of Hydroxychloroquine in Hair Disorders

Ravipati,

Randolph,

Al-Salhi

et al. 2023

Skin Appendage Disord

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Hydroxychloroquine (HCQ) is an antimalarial that is utilized to treat a range of dermatologic and autoimmune disorders. With its ability to alter immunologic mechanisms, it has been used to slow or halt the progression of hair loss in conditions secondary to autoimmune dysfunction. Lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and alopecia areata (AA) are hair disorders with underlying autoimmune components and no standardized treatment guidelines. We summarized the available literature on the use of HCQ to treat LPP, FFA, and AA. For all three conditions, HCQ showed variable efficacy from halted hair loss to no improvement. While patients did show success with HCQ treatment, there were no clear treatment patterns. Regimens ranged from HCQ monotherapy to combination treatments with other agents like steroids. Overall, HCQ should certainly be considered by clinicians as a treatment option for patient suffering from these hair disorders. While there is no standardized treatment, incorporation of HCQ should take into consideration individual patient characteristics, clinical judgment, and risks of side effects.

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Cutaneous Mucinoses

Rongioletti

2016

Rook's Textbook of Dermatology, Ninth Edition

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The cutaneous mucinoses are a heterogeneous group of disorders whose main characteristic is abnormal mucin deposition in the skin. The aetiopathogenesis of cutaneous mucinoses is unknown, although cytokines such as tumour necrosis factor α and β, interleukin 1, interleukin 6 and transforming growth factor β and/or polyclonal and monoclonal immunoglobulins and other unidentified factors in the serum of affected patients may induce up‐regulation of glycosaminoglycan synthesis. The cutaneous mucinoses are divided into two categories: (i) primary cutaneous mucinoses in which the mucin deposit is the main histological feature resulting in clinically distinctive lesions; and (ii) secondary mucinoses in which the mucin deposition is only an additional histological epiphenomenon. Primary mucinoses can be divided into dermal and follicular mucinoses. The former includes lichen myxoedematosus, reticular erythematous mucinosis, scleroedema, mucinoses in thyroid disease, papular and nodular mucinosis in connective tissue diseases, self‐healing juvenile cutaneous mucinosis, cutaneous focal mucinosis, digital myxoid cyst; the latter include Pinkus follicular mucinosis and urticaria‐like follicular mucinosis. Associated disorders include paraproteinaemia (scleromyxoedema, scleroedema), diabetes mellitus (scleroedema), hyperthyroidism (pretibial myxoedema), hypothyroidism (generalized myxoedema) and lupus erythematosus, dermatomyositis or scleroderma (papular and nodular mucinosis in connective tissue diseases).

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Familial follicular mucinosis: A case letter

Cited by 5 publications

References 5 publications

Follicular mucinosis: a review

Follicular mucinosis: a review

Use of Hydroxychloroquine in Hair Disorders

Cutaneous Mucinoses

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