Familial frontal fibrosing alopecia in two male families

Porriño‐Bustamante, María Librada; García‐Lora, E.; Buendía‐Eisman, A.; Arias‐Santiago, Salvador

doi:10.1111/ijd.14499

Cited by 8 publications

(13 citation statements)

References 10 publications

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“…However, although this group seems to be the most frequently affected, it is not the only one. The first report of a man with FFA dates from 2002 [ 7 ], but many more have been published since then [ 3 , 8 , 9 ]. Moreover, a fair number of cases of FFA in premenopausal women have been published since its first description [ 10 , 11 ].…”

Section: Epidemiology and Demographic Datamentioning

confidence: 99%

“…Male patients with FFA seem to be affected with FFA at a younger age than women, with a mean age of onset of 47.3 years [ 20 ]. FFA in men is probably underdiagnosed because of its overlap with androgenetic alopecia (AGA); indeed, the main complaint among men having FFA is usually eyebrow loss rather than scalp alopecia [ 9 ].…”

Section: Epidemiology and Demographic Datamentioning

confidence: 99%

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Frontal Fibrosing Alopecia: A Review

Porriño‐Bustamante

Fernández‐Pugnaire

Arias‐Santiago

2021

JCM

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Frontal fibrosing alopecia is a scarring alopecia, the prevalence of which is increasing worldwide since its first description in 1994. The reason for this emerging epidemic may be a higher exposure to an unknown trigger, although its aethiology and pathogenesis still remain enigmatic. Clinical, trichoscopic, sonographic, and histopathologic findings are allowing clinicians to understand more aspects about this type of cicatricial alopecia. Several treatments have been used in frontal fibrosing alopecia, although the 5-alpha reductase inhibitors seem to be the most promising. The aim of this report is to provide a compilation about the published data regarding frontal fibrosing alopecia in a narrative review.

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Section: Epidemiology and Demographic Datamentioning

confidence: 99%

Section: Epidemiology and Demographic Datamentioning

confidence: 99%

Frontal Fibrosing Alopecia: A Review

Porriño‐Bustamante

Fernández‐Pugnaire

Arias‐Santiago

2021

JCM

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“…Axillary and pubic hairs were affected in 33.3 and 16.6% of our patients, respectively; in contrast to the patients of previous F-FFA reports, who were affected in 21.8 and 15.6%, respectively. Beard involvement was mentioned in 2 of 6 male patients [2, 16], representing 33.3% of the total.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Frontal Fibrosing Alopecia: Is There a Link in Relatives?

Ocampo‐Garza

Orizaga-Y-Quiroga

Olvera-Rodríguez

et al. 2021

Skin Appendage Disord

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Frontal fibrosing alopecia (FFA) is an acquired primary lymphocytic cicatricial alopecia characterized by frontotemporal hairline recession, leading to scarring alopecia with a band-like distribution. Prevalence is increasing worldwide, being the most frequent cause of primary scarring alopecia. The natural history of this condition is variable; however, slow progression with spontaneous remission is the most frequent reported outcome. The etiopathogenesis of FFA remains to be elucidated; numerous hypotheses concerning hormonal effects, environmental factors, and genetic predisposition have been proposed. Special interest on genetic basis has emerged since the first familial case was reported. Only a few more familial cases have been published. We report 6 additional cases of female patients with familial FFA (F-FFA) from 3 different families. Sixty-six percent had a family history of autoimmune disease in first-degree relatives; these same patients had a personal history of autoimmune disease. The families described in this cohort study plus the personal and family history of autoimmune disease, as well as the recently described involved genomic loci; reinforced the hypothesis of this disease being genetic. It is important to consider studying this entity since there are scarce data regarding familial cases and this might give us a better insight toward understanding its pathogenesis.

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“…The current case represents the 25 th and resulted in a total of 59 individual cases [Table 1]. 4,[7][8][9][10][11][12][13][14][15][16] Most affected family members were women (88%) but some families had both men and women (8%) who were affected; only one family presented with only affected males (4%). Analysis of the familial relationships showed that the most common relationship was between sisters (56%) followed by mother and daughter (32%) and brother and sister (8%).…”

Section: Case Reportsmentioning

confidence: 99%

“…5 Genetic factors have also been linked to this disease, as family cases reported in the literature to date suggest. 4,[7][8][9][10][11][12][13][14][15][16][17][18][19] Finally some authors have stated an autoimmune origin due to the inflammatory infiltrates in the bulb, the similarities to LPP and the association with other autoimmune diseases. 17 Family groups of FFA are an infrequently described phenomenon, with unknown prevalence among all cases of FFA.…”

Section: Case Reportsmentioning

confidence: 99%

Familial Frontal Fibrosing Alopecia

Cuenca‐Barrales

Ruiz‐Villaverde

Molina‐Leyva

2021

Sultan Qaboos Univ Med J

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Frontal fibrosing alopecia (FFA) is an emerging disease in Western countries. We present the cases of three sisters who were referred simultaneously to the Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain, in 2018. All patients suffered from at least partial frontotemporal hairline recession and eyebrow loss. Following trichoscopic examination, the three sisters were diagnosed with FFA. Only one of the sisters agreed to be treated; she was prescribed with topical clobetasol propionate solution and minoxidil and achieved disease control at the three-month follow-up. These patients represent a new case of familial FFA wherein three sisters as well as their mother were affected by FFA. A systematic review found a total of 24 cases of familial FFA, of which this report is the 25th. In the majority of families, only females were affected (88%) while in the remainder both males and females (8%) were affected; there was only one family where only males were affected (4%). The relationship between the affected individuals was predominately between sisters (56%) followed by mother and daughter (32%). The median age was 61 years old (range: 14–88 years) and the duration of the disease ranged between 3–360 months. Family groups of FFA are an infrequently described phenomenon with unknown prevalence. Keywords: Alopecia; Dermatology; Hair Diseases; Case Report; Spain.

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Familial frontal fibrosing alopecia in two male families

Cited by 8 publications

References 10 publications

Frontal Fibrosing Alopecia: A Review

Frontal Fibrosing Alopecia: A Review

Frontal Fibrosing Alopecia: Is There a Link in Relatives?

Familial Frontal Fibrosing Alopecia

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