Familial frontal fibrosing alopecia treated with dutasteride, minoxidil and artificial hair transplantation

Cranwell, William; Sinclair, Rodney

doi:10.1111/ajd.12499

Cited by 26 publications

(28 citation statements)

References 18 publications

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“…Literature regarding FFA and hair transplantation reports a majority of failed transplant vitality [15,[19][20][21][22]. Although hair growth for the patients who had successfully traversed at least 2 years of stable disease was initially excellent, recipient dominance lead to a recurrence of FFA at graft sites by 4 years post-transplant in multiple cases [20][21][22].…”

Section: Resultsmentioning

confidence: 99%

“…Although hair growth for the patients who had successfully traversed at least 2 years of stable disease was initially excellent, recipient dominance lead to a recurrence of FFA at graft sites by 4 years post-transplant in multiple cases [20][21][22]. As with patients with CCCA, efficacy of hair transplantation in FFA appears to be directly correlated with the stability of inflammation prior to surgery.…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia

Ekelem

Pham

Mesinkovska³

2018

Skin Appendage Disord

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Importance: Hair loss, or alopecia, is one of the most commonly presented problems in dermatology. Scarring alopecias are considered particularly damaging due to limited success in slowing permanent disease progression, and current treatment methods, such as intralesional and topical steroids and topical minoxidil, are largely ineffective. Objective: Hair transplantation is a debated treatment option for advanced cases of primary scarring alopecia. This study reviews the efficacy of hair transplantation as a treatment option for primary scarring alopecia. Evidence Review: A primary literature search was conducted using PubMed to identify articles in scarring alopecia and hair transplants published from 1960 to the present time. Findings: Fifteen reports with 34 patients were included in this review. Twenty six patients experienced moderate to positive results, while 8 patients experienced negative results or recurrence of disease. Positive hair transplantation results have been reported in patients with central centrifugal cicatricial alopecia, en coup de sabre, discoid lupus erythematous, pseudopelade de brocq, and folliculitis decalvans. Positive and negative results were observed in patients with lichen planopilaris and frontal fibrosing alopecia. Conclusion and Relevance: Findings show that hair transplant surgery can be considered as a treatment option for certain primary scarring alopecias. However, data must be interpreted with caution due to concern for positive-result publication bias.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia

Ekelem

Pham

Mesinkovska³

2018

Skin Appendage Disord

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“…However, treatment efficacy was difficult to establish in this case due to several concurrent treatment. Furthermore, this patient was also on hydroxychloroquine and methotrexate for underlying rheumatoid arthritis …”

Section: Efficacy Of 5ari In Ffamentioning

confidence: 99%

“…Furthermore, this patient was also on hydroxychloroquine and methotrexate for underlying rheumatoid arthritis. 12…”

Section: Efficacy Of 5ari In Ffamentioning

confidence: 99%

5‐alpha‐reductase inhibitor treatment for frontal fibrosing alopecia: an evidence‐based treatment update

Murad

Bergfeld

2018

Acad Dermatol Venereol

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“…Alopecia is commonly considered a defect with apparently no significant health consequences. However, one should not underestimate the fact that hair loss can affect self-acceptance, causing depression and anxiety [27,28]. Additionally, an early onset of androgenic alopecia is associated with both an increased metabolic syndrome and an increased risk of ischemic heart disease [29].…”

Section: Hair Loss and Hair Follicle Stem Cellsmentioning

confidence: 99%

Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration

Ahmadi-Ashtiani

Bishe

Baldisserotto

et al. 2020

IJMS

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Cutaneous stem cells, gained great attention in the field of regenerative medicine as a potential therapeutic target for the treatment of skin and hair disorders and various types of skin cancers. Cutaneous stem cells play a key role in several processes like the renovation of skin structures in the condition of homeostasis and after injuries, the hair follicle growth and the reconstruction and production of melanocytes. Thus, gaining effective access to skin stem cells for therapeutic interventions that often involve active molecules with non-favorable characteristics for skin absorption is a valuable achievement. The topical route with high patient compliance and several other benefits is gaining increasing importance in basic and applied research. However, the major obstacle for topical drug delivery is the effective barrier provided by skin against penetration of the vast majority of exogenous molecules. The research in this field is focusing more and more on new strategies to circumvent and pass this barrier effectively. In this article the existing approaches are discussed considering physical and chemical methods along with utilization of novel drug delivery systems to enhance penetration of drugs to the skin. In particular, attention has been paid to studies finalized to the delivery of molecules to cutaneous stem cells with the aim of transferring signals, modulating their metabolic program, inducing physiological modifications and stem cell gene therapy.

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Familial frontal fibrosing alopecia treated with dutasteride, minoxidil and artificial hair transplantation

Cited by 26 publications

References 18 publications

A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia

A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia

5‐alpha‐reductase inhibitor treatment for frontal fibrosing alopecia: an evidence‐based treatment update

Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration

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