Familial hiatal hernia in a large five generation family confirming true autosomal dominant inheritance

Carré, I. J.; Johnston, Brian T.; Thomas, Paul S.; Morrison, P. J.

doi:10.1136/gut.45.5.649

Cited by 61 publications

(33 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Although most cases of HH are isolated, familial inheritance of HH has been shown in humans, with evidence pointing to an autosomal dominant mode of inheritance. 36 Familial inheritance has not been shown in animals but Shar-pei dogs do have a breed predisposition for the condition. 7,14,23 Shar-pei dogs also have a predisposition for poor oesophageal motility and oesophageal redundancy, although these can be incidental radiographic findings not associated with clinical signs.…”

Section: Displacement Of the Oesophagogastric Junction And Gastrooesmentioning

confidence: 95%

Hiatal hernia controversies ‐ a review of pathophysiology and treatment options

Sivacolundhu¹,

Read

Marchevsky³

2002

Aust Veterinary J

View full text Add to dashboard Cite

Hiatal hernia is not completely understood in humans or animals. It has a complex multifactorial aetiology and pathophysiology. A primary disturbance of the lower oesophageal sphincter has not been shown in humans or animals. Knowledge of pathophysiology is necessary to institute appropriate treatment. Medical and/or surgical therapy is not indicated in asymptomatic cases. Medical treatment should be used for up to 1 month in stable cases of sliding hiatal hernia. Paraoesophageal hiatal hernias and any large sliding hiatal hernia should be considered for prompt surgical treatment. Surgical techniques used depend on the type of hiatal hernia present. Surgical treatment of hiatal hernia cases should be performed by experienced surgeons, and must include hiatal closure and gastropexy. The Nissen fundoplication procedure has been discontinued in the veterinary field due to poor success rates, coupled with the published view that there is a marked difference in pathophysiology between humans and dogs. Reported complications associated with the original Nissen fundoplication technique are identical in the human and veterinary literature. There have been no complications reported with use of the modified or 'floppy' Nissen fundoplication in dogs. Both oesophagopexy and Nissen fundoplication require further evaluation in small animals.

show abstract

Section: Displacement Of the Oesophagogastric Junction And Gastrooesmentioning

confidence: 95%

Hiatal hernia controversies ‐ a review of pathophysiology and treatment options

Sivacolundhu¹,

Read

Marchevsky³

2002

Aust Veterinary J

View full text Add to dashboard Cite

show abstract

“…[2][3][4] Increasing age (>50 years) and being overweight (body mass index >25 kg/m 2 ) are the most common risk factors for HH formation. [5][6][7][8][9] A study conducted in 2013 by Che et al found that 40% of the morbidly obese patients had a HH, 10 while subsequent studies have shown that HH prevalence is associated with obesity prevalence and increasing age. [5][6][7][8][9] A study conducted in 2013 by Che et al found that 40% of the morbidly obese patients had a HH, 10 while subsequent studies have shown that HH prevalence is associated with obesity prevalence and increasing age.…”

Section: Introductionmentioning

confidence: 99%