Familial hypercholesterolaemia

Knipe, Henry; Dunn, Douglas

doi:10.53347/rid-154524

Cited by 1 publication

(1 citation statement)

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“…In 2011, the UK National Screening Committee (NSC) determined that an adult screening programme specific to FH was unnecessary and that the NHS Health Checks (HCs) programme should be adequate for identifying the majority of the population with FH [38]. The HCs commenced in 2009 for adults in England aged 40-74 years, with the aim of detecting signs of preventable conditions, including diabetes, heart disease, kidney disease, stroke, and dementia [39].…”

Section: Fh Identification In the Uk Falls Well Below Fh Identificati...mentioning

confidence: 99%

A comparison of the Netherlands, Norway and UK Familial Hypercholesterolemia screening programmes with implications for target setting and the UK’s NHS Long Term Plan

Page

Zheng

Wang

et al. 2023

Preprint

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Aims. We sought to determine the most efficacious and cost effective strategy to follow when developing a national screening programme by comparing and contrasting the national screening programmes of Norway, the Netherlands and the UK. Methods and results. Comparing the detection rates and screening profiles between the Netherlands, Norway, the UK and constituent nations (England, Northern Ireland, Scotland and Wales) it is clear that maximising the number of relatives screened per index case leads to identification of the greatest proportion of an FH population. The UK has stated targets to detect 25% of the FH population of England across the 5 years to 2024 with the NHS Long Term Plan. However, this is grossly unrealistic and, based on prepandemic rates, will only be reached in the year 2098. We also modelled the efficacy and costeffectiveness of two screening strategies: 1) Universal screening of 1 to 2 year olds, 2) electronic healthcare record screening, in both cases coupled to reverse cascade screening. We found that index case detection from electronic healthcare records was 56% more efficacious than universal screening and, depending on the cascade screening rate of success, 36% to 43% more cost effective per FH case detected. Conclusion. The UK is currently trialling universal screening of 1 to 2 year olds to contribute to national FH detection targets. Our modelling suggests that this is not the most efficacious or cost effective strategy to follow. For countries looking to develop national FH programmes, screening of electronic healthcare records, coupled to successful cascade screening to blood relatives is likely to be a preferable strategy to follow.

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Section: Fh Identification In the Uk Falls Well Below Fh Identificati...mentioning

confidence: 99%