Familial hypercholesterolaemia: A global call to arms

Vallejo‐Vaz, Antonio J.; Seshasai, Sreenivasa Rao Kondapally; Cole, Della; Hovingh, G. Kees; Kastelein, John J.P.; Mata, Pedro; Raal, Frederick J.; Santos, Raul D.; Soran, Handrean; Watts, Gerald F.; Abifadel, Marianne; Aguilar-Salinas, Carlos A.; Akram, Asif; Alnouri, Fahad; Alonso, Rodrigo; Al-Rasadi, Khalid; Banach, Maciej; Bogsrud, Martin P.; Bourbon, Mafalda; Bruckert, Éric; Car, Josip; Corral, Pablo; Descamps, Olivier; Dieplinger, Hans; Durst, Ronen; Freiberger, Tomáš; Gaspar, Isabel; Genest, Jaques; Harada‐Shiba, Mariko; Jiang, Lixin; Kayıkçıoğlu, Meral; Lam, Carolyn S.P.; Latkovskis, Gustavs; Laufs, Ulrich; Liberopoulos, Evangelos N.; Nilsson, Lennart; Nordestgaard, Børge G.; O’Donoghue, John; Sahebkar, Amirhossein; Schunkert, Heribert; Shehab, Abdulla; Stoll, Mario; Su, Ta Chen; Сусеков, А. В.; Widén, Elisabeth; Catapano, Alberico L.; Ray, Kausik K.

doi:10.1016/j.atherosclerosis.2015.09.021

Cited by 161 publications

(129 citation statements)

References 11 publications

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“…Patient support and advocacy groups led by affected individuals have often helped to raise FH awareness in the general public 38) . Interactions between national patient support groups to share and communicate ideas and resources would be helpful, particularly in the Asian region where advocacy activity is minimal 38) .…”

Section: Patient Perspectives: Family Support Groupsmentioning

confidence: 99%

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International Developments in the Care of Familial Hypercholesterolemia: Where Now and Where to Next?

Pang

Lansberg

Watts

2016

JAT

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Section: Patient Perspectives: Family Support Groupsmentioning

confidence: 99%

“…Integrated screening programs are sparse in the Asia region 38) and limited to the city states of Hong Kong 39) and Singapore 40) . Owing to high population densities, screening and cascade testing services may be particularly efficient and beneficial.…”

Section: Introductionmentioning

confidence: 99%

International Developments in the Care of Familial Hypercholesterolemia: Where Now and Where to Next?

Pang

Lansberg

Watts

2016

JAT

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“…Concurrently, the European Atherosclerosis Society FH Studies Collaboration has been launched as an ambitious global initiative, and through a consortium of major FH registries worldwide, aims to generate large-scale data on how FH is detected and managed and explore the clinical implications. The ultimate aims of this proposal are to disseminate FH information and facilitate all countries to improve the care of patients and families with FH 47) . In summary, there are relatively limited epidemiological data on FH in Asia, and the frequency of FH is unclear in many Asian countries.…”

Section: Clinical Care Of Fh Patients In Asian Countriesmentioning

confidence: 99%

Familial Hypercholesterolemia in Asian Populations

Zhou

Zhao

2016

J Atheroscler Thromb

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Familial hypercholesterolemia (FH) is the most common autosomal disorder characterized by an elevated low-density lipoprotein-cholesterol level and a high risk of premature cardiovascular disease. In this review, we summarize information on FH studies in Asian countries, focusing on mean cholesterol level, FH frequency, diagnostic criteria, genotypes, and clinical care of FH patients in Asian populations. Compared with Western countries, most Asian countries had lower mean cholesterol levels, with a significant variation between different countries. In the limited studies reported, a frequency of 1/900 was reported in Hokuriku district, Japan in 1977 and a frequency of 1/85 among Christian Lebanese in 1979. Recently, a population study in China reported frequencies of 0.47% and 0.28%. However, the different FH frequencies reported were based on different diagnostic criteria. Of 28 publications from 16 Asian countries or regions, 14 used self-defined FH criteria. Only one specific guideline for FH was available, which was developed by Japanese scientists. Six Asian countries joined the Make Early Diagnosis to Prevent Early Deaths program in the late 1990s, and the estimated diagnosis rates of FH ranged from 3% to 10% in these countries. A more recent study explored the awareness, knowledge, and perception of FH among practitioners in Japan, Korea, and Taiwan. The study found that the correct rates of these FH-related questions were low and concluded that lack of country-specific criteria and guidelines may contribute to the lack of FH knowledge in the present survey. More attention and resources should be focused on raising awareness, improving care, and increasing FH research in Asian populations. J Atheroscler Thromb, 2016; 23: 539-549.

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“…The United Kingdom, a country with a highly developed healthcare system and a sophisticated guideline for the care of FH developed by the National Institute for Health and Care Excellence (NICE), will provide benchmark data for international comparison. Further networking has spawned a new association with the FH Studies Collaboration (FHSC) 21) .…”

Section: Core Group and Networkmentioning

confidence: 99%

“…Transfer of the research findings to enhance the awareness and knowledge of FH among healthcare professionals is an essential future objective, including the incorporation and utilization of the findings into routine clinical practice. The wider impact and effectiveness of future studies relies on the development of closer collaborative efforts with other international initiatives, such as the FH Studies Collaboration (FHSC) 21) and the ScreenPro FH Project 53) . At country, region, and local levels, the instigation of partnership between clinical and political stakeholders and patient support groups is essential to effectively translate current and future evidence into better healthcare for all patients and families with FH 54) .…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Translational Research for Improving the Care of Familial Hypercholesterolemia: The “Ten Countries Study” and Beyond

Watts

Ding²,

George

et al. 2016

J Atheroscler Thromb

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Familial hypercholesterolemia (FH) is the most common and serious form of inherited hyperlipidaemia. Dominantly inherited with high penetrance, untreated FH leads to premature death from coronary artery disease due to accelerated atherosclerosis from birth. Despite its importance, there is still a major shortfall in awareness, detection and treatment of FH worldwide. International models of care for FH have recently been published, but their effective implementation requires the garnering of more knowledge about the condition. The "Ten Countries Study" aims to investigate diagnostic, epidemiological and service aspects, as well as physician practices and patient experiences of FH in several countries in the Asia-Pacific Region and the Southern Hemisphere. Five observational studies are being undertaken that will systematically investigate the following aspects of FH: the phenotypic predictors of low-density lipoprotein receptor mutations, the point prevalence in available community populations, current knowledge and clinical practices among primary care physicians, availability and utilisation of services and facilities, and patient perceptions and personal experiences of the condition. The information gathered will inform better clinical practice and will enable the development of country-specific models of care for FH.

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Familial hypercholesterolaemia: A global call to arms

Abstract: r Endocrinologie m etabolisme et prevention cardiovasculaire, Institut E3M et IHU cardiom etabolique (ICAN), HôpitalPiti eSalpêtri ere,

Cited by 161 publications

References 11 publications

International Developments in the Care of Familial Hypercholesterolemia: Where Now and Where to Next?

International Developments in the Care of Familial Hypercholesterolemia: Where Now and Where to Next?

Familial Hypercholesterolemia in Asian Populations

Translational Research for Improving the Care of Familial Hypercholesterolemia: The “Ten Countries Study” and Beyond

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