Familial Idiopathic Intracranial Hypertension in Two Non-obese Chinese Sisters

Qiao, Lei; Wei, Yanping

doi:10.3389/fneur.2020.569432

Cited by 7 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only a small number of literature reports about IIH in non-obese young women. Other instances of rare cases of IIH are familial or genetic predisposition, including atypical demographics such as men and older people [7,8]. One study reported that IIH may be diagnosed in older patients with normal Body Mass Index (BMI) because there is a lower suspicion index in the normal BMI population [8].…”

Section: Discussionmentioning

confidence: 99%

Headache with Isolated Sixth Cranial Nerve Palsy in an Overweight Woman: A Case of Idiopathic Intracranial Hypertension

Goe Xian Jeff,

Sharifah Najwa Syed Mohamad,

Siti Noorfaezah Abdul Kadir

et al. 2024

MJoSHT

View full text Add to dashboard Cite

Idiopathic intracranial hypertension (IIH), also known as pseudotumour cerebri, has an estimated incidence of 1 to 2 in 100,000 people per year. IIH commonly affects obese young women, where its pathogenesis, however, is not clearly understood. Patients present to the emergency department with a wide array of presentations. In light of this, we present a case of isolated sixth cranial nerve palsy in a non-obese young woman due to IIH in which brain imaging studies showed no abnormality; however, lumbar puncture reveals an opening pressure of more than 50 cmH2O. This case would help to alert physicians to consider IIH as one of the differential diagnoses when encountering such cases, as an uncommon presentation in the non-obese patient, and prompt referral is important to avoid unnecessary delay in the treatment of IIH.

show abstract

Section: Discussionmentioning

confidence: 99%

Headache with Isolated Sixth Cranial Nerve Palsy in an Overweight Woman: A Case of Idiopathic Intracranial Hypertension

Goe Xian Jeff,

Sharifah Najwa Syed Mohamad,

Siti Noorfaezah Abdul Kadir

et al. 2024

MJoSHT

View full text Add to dashboard Cite

show abstract

“…erefore, as long as the syndrome type diagnosis of the disease was accurate, it was quite beneficial in the treatment effect of the disease. e results of many studies using TCM therapy show that the therapeutic effect of TCM therapy was better than that of simple western medicine therapy and had the characteristics of safety, effectiveness, and small side effects [25][26][27]. It also indicates that the incidence of adverse reactions in the acupoint application group (12%) had no significant statistical significance compared with the control group (10%) (P > 0.05), suggesting that there was no significant difference in the safety between acupoint application therapy and conventional western medicine.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Effect of Acupoint Sticking Therapy on Idiopathic Edema by Ultrasound Imaging Based on Deep Learning Algorithm

Wang

Zhao

et al. 2022

Scientific Programming

View full text Add to dashboard Cite

This study was aimed to evaluate the therapeutic effect of acupoint application therapy on specific edema by using denoising convolutional neural network (DnCNN) ultrasound images. 144 patients with idiopathic edema were selected as the research objects, and they were randomly divided into the conventional treatment group and the acupoint application group. Traditional Chinese medicine (TCM) symptom score, quality-of-life score, and adverse reactions were compared between the two groups before and after treatment. Ultrasound images based on the deep learning algorithm were used to evaluate the efficacy. The results showed that compared with conventional ultrasound, ultrasound based on DnCNN was more accurate in the diagnosis of idiopathic edema. The total effective rate of edema treatment in the acupoint application group was higher than that in the conventional treatment group (45% vs 93%, P < 0.01 ). After treatment, the scores of TCM symptoms in the acupoint application group were lower than those in the conventional treatment group, and the quality-of-life score in the acupoint application group was higher than that in the conventional treatment group P < 0.05 . There was no significant difference in the incidence of adverse reactions between the two groups P > 0.05 . In summary, ultrasound-assisted examination based on the algorithm is accurate in the diagnosis of idiopathic edema. Acupoint application therapy has a significant effect on idiopathic edema and does not increase the incidence of adverse reactions, which has a guiding role in clinical treatment.

show abstract

“…This is also supported by previous reports of non-obese familial IIH. 4 , 5 , 6 , 12 Karaman et al have reported six nonobese family members with IIH based on papilledema, however, three of them were diagnosed “presumptively” as they declined lumbar puncture. 5 Beri et al have reported a mother and two daughters with IIH with no obesity; the first daughter with typical IIH presentation with papilledema and high CSF opening pressure while the second daughter had documented high CSF opening pressure but no papilledema.…”

Section: Discussionmentioning

confidence: 99%