1992
DOI: 10.1097/00004872-199209000-00025
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Familial influence upon NaCI sensitivity in patients with essential hypertension

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Cited by 10 publications
(7 citation statements)
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“…8 This concept has been extended to normotensive individuals as well. 9 Furthermore, a possible involvement of a genetic factor has been reported in this salt sensitivity 10 and recent studies suggest that insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin-converting Correspondence: Dr S Umemura, Second Department of Internal Medicine, Yokohama City University, 3-9 Fukuura, Kanazawaku, Yokohama, 236 Japan ing 11 g salt/day, which confirmed the previous results. The distribution of genotypes and alleles of ACE gene I/D polymorphism was similar to that in the Japanese and Chinese, who had five-times more hypertensives while consuming almost as much salt as Nepalese, but significantly different from those in Caucasians.…”
Section: Introductionsupporting
confidence: 84%
“…8 This concept has been extended to normotensive individuals as well. 9 Furthermore, a possible involvement of a genetic factor has been reported in this salt sensitivity 10 and recent studies suggest that insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin-converting Correspondence: Dr S Umemura, Second Department of Internal Medicine, Yokohama City University, 3-9 Fukuura, Kanazawaku, Yokohama, 236 Japan ing 11 g salt/day, which confirmed the previous results. The distribution of genotypes and alleles of ACE gene I/D polymorphism was similar to that in the Japanese and Chinese, who had five-times more hypertensives while consuming almost as much salt as Nepalese, but significantly different from those in Caucasians.…”
Section: Introductionsupporting
confidence: 84%
“…22 The phenomenon of salt sensitivity, present in Ϸ50% of patients with essential hypertension, may have some familial influence. 23,24 In fact, the BP response to salt overload, an indirect measure of salt sensitivity, has been reported to be increased in normotensive sons of hypertensive parents. 24 However, another study showed negative results in normotensive sons of subjects with high and low BPs with 4 weeks of low and high salt intakes.…”
Section: Discussionmentioning
confidence: 99%
“…This information may serve as a framework for endurance exercise guidelines designed to lower blood pressure in hypertension associated with a family history. Oshima et al (1992) have observed that plasma renin activity on a low sodium chloride (NaCl) diet was lower, and the erythrocyte sodium (Na + ) concentration higher in hypertensive patients with a family history of hypertension compared to those with no such history. In addition the elevations in mean blood pressure, and in erythrocyte Na + concentration with a high NaCl diet were greater in patients with a family history.…”
Section: Discussionmentioning
confidence: 99%