Familial intussusception

Abstract

We concluded that hereditary predisposition, such as anatomical basis, may be considered as an etiological factor in many cases of idiopathic intussusception. In these predisposed families, if they have inducements such as viral infections as the acquired agents, intussusception will occur very easily.

Simultaneous Intussusception in Monozygotic Twins

“…On the other hand, a genetic predisposition has been suggested in families (3). There was estimated that the risk to siblings is about 5-20 times more than that for the general population in literature (4).…”

“…Intussusception is a well-known disease, and one of the most frequent causes of acute bowel obstruction in children aged 3-18 months, with an incidence of 0.1-0.4% of live births. Although idiopathic intussusception has not been considered a genetic disease, it has also been reported in families and relatives (1)(2)(3)(4). Herein, we present the first case report in the English literature of simultaneous occurring intussusception in monozygotic twins.…”

Intussusception: An anatomical perspective with review of the literature

“…McLaughlin (1948) proposed that ileocolic and ileocecal are most common because of the disproportionate growth between the colon and the ileum in infancy, both being of similar size at birth. The disproportion between the protruding ileocecal valve and the ileum in infancy may form the apex of an ileocecal intussusception (Cooke and Lewis, 1960;Oshio et al, 2007). Perrin and Lindsay (1921) studied the anatomy of the cecum and ileum in children less than 1 year of age compared with older children and found that younger children have a more prominent valve with more lymph tissue congregated nearby.…”

“…In children, a mobile cecum and malrotation could allow for the ileum to pass into the cecum and then the cecum to pass into the colon (Tatekawa et al, 1998;Stringer and Babyn, 2000;Oshio et al, 2007). The pairing of malrotation and intussusception is called Waugh's syndrome (Brereton, 1986;Breckon and Hadley, 2000;Inan et al, 2004).…”

“…However, it is the most common cause of small bowel obstruction in infants (Felix et al, 1976;West et al, 1987;Huang and Warshauer, 2003;Silen, 2005) and occurs in 56 of 100,000 infants per year in USA (Parashar et al, 2000). Intussusception occurs most commonly in infants aged 5-9 months (Daneman and Navarro, 2003;Oshio et al, 2007) or according to other authors in children aged 3-12 months (Ladd and Gross, 1934;Silen, 2005) with 67% of the cases occurring by the first year of age. The peak incidence is at 7 months with the majority of cases being idiopathic (Ladd and Gross, 1934;Silen, 2005).…”