Familial Mediterranean Fever

Muhn, Channy; Rosenthal, Donald; Browne, Charmaine; Jakubovic, Henry R.; Fisher, Benjamin

doi:10.1001/archderm.134.8.929

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…10 Erysipelas-like erythema is the most common cutaneous manifestation of FMF, and it generally shows superficial and deep perivascular and interstitial infiltration of predominantly neutrophils in the dermis. 7,11 However, in previous studies, histological examination of erysipelas-like erythema in FMF showed slight edema in the superficial dermis, sparse perivascular infiltration with lymphocytes and neutrophils, 12 and panniculitis. 13 Other types of skin eruptions such as Henoch-Sch€ onlein purpura, urticaria, angioedema, diffuse erythema of the face and/or trunk, diffuse erythema of the palms and soles followed by mild desquamation of the skin, 14 and subcutaneous nodules have also been reported in FMF.…”

Section: Discussionmentioning

confidence: 83%

“…Erysipelas‐like erythema is the most common cutaneous manifestation of FMF, and it generally shows superficial and deep perivascular and interstitial infiltration of predominantly neutrophils in the dermis . However, in previous studies, histological examination of erysipelas‐like erythema in FMF showed slight edema in the superficial dermis, sparse perivascular infiltration with lymphocytes and neutrophils, and panniculitis .…”

Section: Discussionmentioning

confidence: 93%

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Familial Mediterranean fever variant with repeated atypical skin eruptions

Takahashi

Fujisawa

Kimura

et al. 2015

The Journal of Dermatology

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Familial Mediterranean fever (FMF) is characterized by self-limited bouts of fever and polyserositis. Skin involvement is not common in FMF, and erysipelas-like erythema is found to be the most frequent skin eruption which is often accompanied by arthritis and fever, and disappears within 12-72 h. We report a 40-year-old Japanese woman who presented with a 2-year history of recurrent fever with general fatigue, polyarthralgia and transient maculopapular eruptions on her lower extremities and trunk. The histological findings of the maculopapular eruption showed lymphocyte infiltration around the capillaries in the entire dermis. Mutation analysis showed a heterozygous E148Q-P369S mutation of MEFV. These findings suggested a diagnosis of late-onset FMF variant with atypical skin eruptions. The patient was successfully treated with colchicine. Thus, we should pay attention to repeated atypical skin eruptions for the early detection of atypical FMF.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 93%

Familial Mediterranean fever variant with repeated atypical skin eruptions

Takahashi

Fujisawa

Kimura

et al. 2015

The Journal of Dermatology

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Approach to the Patient With Presumed Cellulitis

Kroshinsky

Grossman²,

Fox³

2007

Seminars in Cutaneous Medicine and Surgery

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Dermatologists frequently are consulted in the evaluation and management of the patient with cellulitic-appearing skin. For routine cellulitis, the clinical presentation and patient symptoms are usually sufficient for an accurate diagnosis. However, when the clinical presentation is somewhat atypical, or if the patient fails to respond to appropriate therapy for cellulitis because of routine bacterial pathogens, the differential diagnosis should be rapidly expanded. We discuss the approach to the patient with presumed cellulitis, with an emphasis on the differential diagnosis of cellulitis in both the immunocompetent and immunucompromised patient.

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Amiloidosis sistémicas

Álvarez-Ruiz

García-Río

Daudén

2005

Actas Dermo-Sifiliográficas

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Amyloidoses are a heterogeneous group of diseases characterized by extracellular fibrillar protein deposits in the organs and tissues. These proteins are not biochemically related to each other, but share certain common characteristics, including apple green birefringence with polarized light after staining with Congo red, and beta-pleated sheet configuration through x-ray diffraction. Amyloid deposits may occur in many organs (systemic amyloidoses) or may affect a single tissue (localized or organ-specific amyloidoses). There are different classifications, but in this review the amyloidoses are organized by clinical symptoms, which are determined by the amyloid protein involved. Special attention is given to cutaneous and mucous membrane manifestations, which are often the first sign of the disease and are useful for early diagnosis, thus avoiding more aggressive procedures. The involvement of other organs is analyzed, as are the diagnosis, prognosis and treatment of systemic amyloidoses.

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Familial Mediterranean Fever

Cited by 5 publications

References 11 publications

Familial Mediterranean fever variant with repeated atypical skin eruptions

Familial Mediterranean fever variant with repeated atypical skin eruptions

Approach to the Patient With Presumed Cellulitis

Amiloidosis sistémicas

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