Familial Mediterranean fever and asthma

Tsur, Avishai M; Watad, Abdulla; Gendelman, Omer; Nissan, Daniel; Cohen, Arnon D; Amital, Howard

doi:10.1093/rheumatology/keab159

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…The Clalit Health Services chronic disease registry contains data from pharmaceutical, medical, and administrative databases for both outpatients and inpatients, as described in previous studies. 20,21…”

Section: Designmentioning

confidence: 99%

Ankylosing Spondylitis and the Risk of Hip Fractures: a Matched Cohort Study

et al. 2022

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BACKGROUNDS: It has been hypothesized that ankylosing spondylitis is associated with an increased risk of incident hip fractures due to osteoporosis and risk of falls but the supporting evidence is limited and mixed. OBJECTIVES: To assess the risk of hip fractures in a large cohort of patients with ankylosing spondylitis compared to a matched cohort. DESIGN: A retrospective cohort study. SUBJECTS: Men and women diagnosed with ankylosing spondylitis from 1 January 2002 to 31 December 2018. Matching in a 5:1 ratio was based on age and sex. Followup ended on 23 June 2019. MAIN MEASURES: Cox regression models adjusting for confounders defined in a causal inference framework were used to determine the hazard ratio for hip fractures. KEY RESULT: The final cohorts included 5,909 ankylosing spondylitis patients and 28,671 matched patients. The ankylosing spondylitis cohort had a mean age of 49 (17) years and was composed of 3,762 (64%) men, 3,638 (62%) patients born in Israel, and 1,532 (26%) patients of low residential socioeconomic status. During 45,388 and 224,192 cumulative person-years of follow-up, the ankylosing spondylitis and matched cohorts had 2.47 and 1.63 cases of hip fractures per 1,000 person-years, respectively. Ankylosing spondylitis patients also developed hip fractures earlier (74 [13] vs. 79 [10] years, p = 0.002). Ankylosing spondylitis was associated with hip fractures in the unadjusted (HR = 1.52, 95% CI [1.23-1.88]) and adjusted (HR = 1.56, 95% CI [1.27-1.93]) models. The association was evident in men (HR = 1.65, 95% ) and women (HR = 1.48, 95% CI [1.07-2.05]). CONCLUSION: This study found that ankylosing spondylitis patients developed hip fractures earlier and more often compared to a matched cohort. This study suggests that ankylosing spondylitis patients might benefit from more proactive screening, mitigation, and prevention of risk factors for hip fractures.

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Section: Designmentioning

confidence: 99%

Ankylosing Spondylitis and the Risk of Hip Fractures: a Matched Cohort Study

et al. 2022

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“…The diagnoses are documented by either a primary care physician or specialist using the International Classification of Diseases (ICD). The data is systematically verified and was found to be highly creditable in previous studies (11,12), including study that investigated the association between FM and diabetes mellitus (13). The Ethics Committee of the CHS approved this study and waived the requirement for informed consent.…”

Section: Methodsmentioning

confidence: 53%

“…Moreover, this study lacks information regarding temporality, and the information concerning the criteria for diagnosing the various diseases was unavailable. However CHS data are systematically verified and was found to has high validity in earlier studies (11)(12)(13).…”

Section: Discussionmentioning

confidence: 68%

“…Demographic data including age, sex, body mass index (BMI), smoking status, and socioeconomic status (SES) were obtained from the CHS electronic database. SES was defined based on the location of residence and was obtained from records of the Israeli Ministry of Interior, as previously described (12). GI diagnoses were identified using the following ICD-9 codes: IBS (564.1), gastroesophageal reflux disease (GERD) (530.81, 530.11, 530.10), peptic ulcer disease (PUD) (531, 532, 533), celiac disease (579.0), Crohn's disease (555.0-555.2, 555.9), ulcerative colitis (556), colorectal cancer (153, 154), stomach cancer (151), liver and bile duct cancer (155) and pancreatic cancer (157).…”

Section: Study Variablesmentioning

confidence: 99%

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Association of fibromyalgia with cancerous and non-cancerous gastrointestinal comorbidities: a cross-sectional study

Savin

Tsur

Watad

et al. 2022

Clinical and Experimental Rheumatology

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ObjectiveSeveral studies have shown a higher prevalence of irritable bowel syndrome (IBS) among patients with fibromyalgia yet, data regarding association between fibromyalgia and other gastrointestinal disorders have been relatively overlooked. Our aim was to investigate the association between fibromyalgia and gastrointestinal disorders including both benign and malignant conditions. MethodsWe conducted a retrospective cross-sectional study based on the comprehensive electronic database of the largest health maintenance organisation in Israel. All subjects with a diagnosis of fibromyalgia in their medical records and age-and sex-matched controls were included in the study. We investigated the association of fibromyalgia with benign gastrointestinal disorders including IBS, gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), celiac disease, Crohn's disease, ulcerative colitis, and with gastrointestinal malignancies including colorectal, pancreatic, stomach, liver, and bile duct cancers.

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