Familial Mediterranean fever and atherosclerosis in childhood and adolescence

Vampertzi, Olga; Papadopoulou-Legbelou, Kyriakı; Triantafyllou, Αreti; Δούμα, Στέλλα; Papadopoulou‐Alataki, Efimia

doi:10.1007/s00296-019-04457-8

Cited by 7 publications

(3 citation statements)

References 71 publications

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“…Of 2734, 2704 were irrelevant, and 30 were eligible for full‐text screening. There were 25 studies that might appear to meet the inclusion criteria, but were excluded as studies 9 , 10 , 11 , 12 , 13 because of wrong study design and wrong outcomes. Five studies were included in the meta‐analysis after performing full‐text screening, as shown in (Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta‐analysis

Motawea

Kandil

Varney

et al. 2022

Health Science Reports

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Background and Aim Some studies reported a positive link between familial Mediterranean fever (FMF) and epicardial adipose tissue. Our meta‐analysis aimed to evaluate whether there is a significant association between FMF and increased epicardial adipose tissue thickness. Methods We searched the following databases: PUBMED, WOS, OVID, SCOPUS, and EMBASE. Inclusion criteria were any original articles that reported epicardial adipose tissue in FMF patients with no age restriction, excluding reviews, case reports, editorials, animal studies, and non‐English studies. Thirty eligible studies were screened full text but only five studies were suitable. We used RevMan software (5.4) for the meta‐analysis. Results The total number of patients included in the meta‐analysis in the FMF patients group is 256 (mean age = 24.3), and the total number in the control group is 188 (mean age = 24.98). The pooled analysis between FMF patients and controls was [mean difference = 0.82 (95% CI = 0.25–1.39), p ‐value = 0.005]. We observed heterogeneity that was not solved by random effects ( p > 0.00001). We performed leave one out test by removing the Kozan et al. study, and the heterogeneity was solved ( p = 0.07), and the results were (MD = 0.98, 95% CI = 0.52–1.43, p ‐value < 0.0001). Conclusion FMF patients are at increased risk of developing epicardial adipose tissue compared to controls. More multicenter studies with higher sample sizes are needed to support our results.

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Section: Resultsmentioning

confidence: 99%

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta‐analysis

Motawea

Kandil

Varney

et al. 2022

Health Science Reports

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“…Hastalar akut faz reaktanları açısından değerlendirildiğinde CRP, ESH, lökosit ve fibrinojen düzeylerinin subklinik PAI, AK, CRI-I ve II düzeyleriyle ESH, TG, LDL ve TK arasında istatistiksel olarak anlamlı oranda pozitif korelasyon, HDL ile negatif korelasyon olduğu tespit edildi (p<0,05) (Şekil 1).TartışmaSistemik inflamasyonun endotel disfonksiyonu ve ateroskleroz gelişimde önemli bir rolü olduğu bilinmektedir 6. FMF hastalarında artmış sitokin maruziyeti ile birlikte aterosklerotik sürecin hızlanması ve KVH riskinde artış olması beklenir 17. Bu hızlanmış aterosklerotik sürecin patogenezinde lipid profili değişikliklerinin ve aterojenik indekslerin rolünü araştıran…”

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Ailevi Akdeniz Ateşi Hastalarında Pro-aterojenik Lipid Profili ve Aterojenik İndeksin Değerlendirilmesi / Assessment of Pro-atherogenic Lipid Profile and Atherogenic Index in Patients with Familial Mediterranean Fever

TOÇOĞLU,

GENÇ

2023

Acta Medica Nicomedia

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Amaç: Ailevi Akdeniz Ateşi (FMF) kronik inflamasyon ile karakterize bir hastalıktır. Bu hastalarında artmış sitokin maruziyeti ile birlikte kardiyovasküler hastalık (KVH) riskinde artış olması beklenir. Çalışmamızda FMF hastalarında KVH riskini belirlemek için serum lipid parametrelerini ile aterojenik indeksleri değerlendirmeyi amaçladık. Yöntem: Çalışmada ataksız dönemdeki 102 FMF hastası ile 94 sağlıklı kontrol retrospektif olarak değerlendirildi. Katılımcıların verileri poliklinik verileri incelenerek hastane bilgi sistemi üzerinden kayıt edildi. Aterojenik indeksler lipid değerleri kullanılarak hesaplandı. FMF hastaları subklinik inflamasyonun varlığına göre iki gruba ayrıldı. Bulgular: Total kolesterol (TK), düşük yoğunluklu lipoprotein kolesterol (LDL), aterojenik katsayı (AK), Castelli risk indeksi I ve II (CRI-I ve II) düzeylerinin FMF grubunda sağlıklı kontrollere göre istatistiksel olarak anlamlı oranda daha düşük olduğu tespit edildi (p

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“…Системное воспаление при ПБ является также фактором риска развития атеросклероза, что подтверждается однонаправленными изменениями биомаркеров различных звеньев атерогенеза: утолщение комплекса интима-медиа, повышение уровня воспалительных биомаркеров (С-реактивный белок, фибриноген, липопротеин (а), ИЛ-17), эндотелиальная дисфункция (повышение уровня асимметричного диметиларгинина, ухудшение параметров жесткости артериальной стенки), протромбогенное состояние (повышение уровня ингибитора активатора плазминогена-1) [12]. Фибриноген, один из важных воспалительных маркеров активности ПБ, является также и предиктором ишемических инсультов в общей популяции, в особенности у менее возрастных пациентов [13].…”

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Cerebrovascular manifestations of familial Mediterranean fever

Raskurazhev

Кузнецова

Tanashyan

2022

РНЖ

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This article provides an overview of modern concepts of cerebrovascular manifestations of familial Mediterranean fever (FMV), also known as periodic disease, and describes own clinical observation. Despite the relative infrequency of cerebrovascular accidents in the structure of the clinical phenomenology of FMV, common pathogenetic aspects of these diseases indicate the need for a detailed examination of patients with suspected FMV. In addition, insufficient awareness of physicians about autoinflammatory diseases (of which FMV is a prominent member) underlines the need to include FMV in the spectrum of differential diagnosis of ischemic stroke, including taking into account national characteristics.

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Familial Mediterranean fever and atherosclerosis in childhood and adolescence

Cited by 7 publications

References 71 publications

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta‐analysis

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta‐analysis

Ailevi Akdeniz Ateşi Hastalarında Pro-aterojenik Lipid Profili ve Aterojenik İndeksin Değerlendirilmesi / Assessment of Pro-atherogenic Lipid Profile and Atherogenic Index in Patients with Familial Mediterranean Fever

Cerebrovascular manifestations of familial Mediterranean fever

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