Familial Medullary Carcinoma Of The Thyroid

Block, Melvin A.; Horn, Robert C.; Miller, Joanne L.; Barrett, J. L.; Brush, Brock E.

doi:10.1097/00000658-196709000-00008

Cited by 71 publications

(9 citation statements)

References 30 publications

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“…Several reports have demonstrated familial aggregation of medullary thyroid carcinoma, either in isolation or as part of a multiple endocrine neoplastic syndrome. 45,46 Anthropometric measures have not been included in the majority of thyroid-cancer studies. Dal Maso et al 24 reported that both height and weight were moderately related to thyroid cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Cohort study of thyroid cancer in a San Francisco Bay area population

et al. 2001

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Using data from a large health plan, we performed a cohort study of thyroid cancer among 204,964 persons (aged 10 -89 at baseline in 1964 -1973, 54% female) followed for a median of 20 years. Thyroid carcinoma is rare, representing 0.5% of cancers among U.S. men and 1.7% cancers among U.S. women, but remains the most common malignancy of the endocrine system. 1 Its incidence increased from 1987 to 1991 in the United States, 2 is greater in women than in men and peaks between the ages of 25 and 65. 3,4 The prognosis of well-differentiated, localized thyroid tumors is extremely good. 1 Persons considered to be at high risk include those with a history of radiation treatment during infancy and childhood, 5,6 those with exposure to nuclear testing 7 or to nuclear reactor accidents 8 and those with benign conditions of the thyroid gland. 9 -13 Other putative determinants include diet (notably iodine deficiency or excess), 14,15 hormonal, reproductive 16 -20 and genetic factors. 21,22 Other less well-studied potential risk factors include smoking, alcohol intake, 23 body size and weight gain. 18,24 In this report, we evaluated several potential predictors of thyroid cancer (including demographic, behavioral, medical and reproductive factors as well as occupational exposures) in a large, well-defined, multi-ethnic cohort of men and women enrolled in a health-maintenance organization (HMO) in northern California and followed for up to 33 years. MATERIAL AND METHODS Study design and proceduresWe used a historical cohort study design with measurement of characteristics at baseline (1964 -1973) and prospective follow-up of events from baseline through the end of 1997. The cohort was composed of 95,058 male and 112,838 female subscribers of the Kaiser Permanente Medical Care Program of Northern California, aged 10 -89, who underwent multiphasic health checkups between 1964 and 1973 in San Francisco or Oakland. Of the original cohort, 28 women and 6 men were excluded for having a prior diagnosis of thyroid cancer before the multiphasic checkup. An additional 2,395 women and 503 men were excluded for having a self-reported history of thyroid operation (though the extent of surgical removal was unknown). Thus, the final sample of persons free of thyroid cancer and with an intact thyroid gland consisted of 94,549 men and 110,415 women.Northern California Kaiser Permanente members constitute an ethnic and socio-economic mix that is generally representative of the local population, except that the extremes of wealth and poverty are under-represented. 25 If study participants attended more than 1 checkup, only the data from the first were used.The multiphasic checkup collected information on several demographic factors (age, gender, race/ethnicity and educational attainment), anthropometric measurements, health behaviors (cigarette smoking and alcohol consumption), physiological characteristics (including reproductive factors), medical conditions and occupational exposures using standardized instruments and procedures previously...

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Section: Discussionmentioning

confidence: 99%

Cohort study of thyroid cancer in a San Francisco Bay area population

et al. 2001

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“…Of note, the F/M IRR for medullary carcinoma was 3.73, much higher than the 1.31 in SEER. The higher medullary rate among females in Sao Paulo than in SEER, in contrast to similar rates among males, is also notable, especially because a genetic origin has been suggested for these tumors (10,50). Further research is required to investigate a possible genetic susceptibility in Sao Paulo females.…”

Section: Thyroid Cancer Incidence Trend In Sao Paulo and Seermentioning

confidence: 94%

Thyroid Cancer Incidence Patterns in Sao Paulo, Brazil, and the U.S. SEER Program, 1997–2008

Veiga

Neta

Aschebrook‐Kilfoy

et al. 2013

Thyroid

116

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Background: Thyroid cancer incidence has risen steadily over the last few decades in most of the developed world, but information on incidence trends in developing countries is limited. Sao Paulo, Brazil, has one of the highest rates of thyroid cancer worldwide, higher than in the United States. We examined thyroid cancer incidence patterns using data from the Sao Paulo Cancer Registry (SPCR) in Brazil and the National Cancer Institute's Surveillance Epidemiology End Results (SEER) program in the United States. Methods: Data on thyroid cancer cases diagnosed during 1997-2008 were obtained from SPCR (n = 15,892) and SEER (n = 42,717). Age-adjusted and age-specific rates were calculated by sex and histology and temporal patterns were compared between the two populations. Results: Overall incidence rates increased over time in both populations and were higher in Sao Paulo than in the United States among females (SPCR/SEER incidence rate ratio [IRR] = 1.65) and males (IRR = 1.23). Papillary was the most common histology in both populations, followed by follicular and medullary carcinomas. Incidence rates by histology were consistently higher in Sao Paulo than in the United States, with the greatest differences for follicular (IRR = 2.44) and medullary (IRR = 3.29) carcinomas among females. The overall female/male IRR was higher in Sao Paulo (IRR = 4.17) than in SEER (IRR = 3.10) and did not change over time. Papillary rates rose over time more rapidly in Sao Paulo (annual percentage change = 10.3% among females and 9.6% among males) than in the United States (6.9% and 5.7%, respectively). Regardless of sex, rates rose faster among younger people (<50 years) in Sao Paulo, but among older people ( ‡50 years) in the United States. The papillary to follicular carcinoma ratio rose from < 3 to > 8 among both Sao Paulo males and females, in contrast to increases from 9 to 12 and from 6 to 7 among U.S.males and females, respectively. Conclusions: Increased diagnostic activity may be contributing to the notable rise in incidence, mainly for papillary type, in both populations, but it is not likely to be the only reason. Differences in iodine nutrition status between Sao Paulo and the U.S. SEER population might have affected the observed incidence patterns.

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“…Whereas about 20% of medullary thyroid car cinomas are familial [1,2], nonmedullary thyroid car cinomas were thought to be entirely sporadic until recent clinical reports suggested a familial tendency. Some of the familial occurrences were linked to in herited syndromes, such as polyposis coli (Gardner's syndrome) and multiple endocrine neoplasia (type 1), but others reviewed in table 1 [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] have occurred without evidence of underlying syndromes.…”

Section: Introductionmentioning

confidence: 99%