Familial occurrence of papillary thyroid carcinoma

Abstract

We report two kindreds from northern Norway with 7 and 4 cases of papillary thyroid carcinoma in otherwise healthy, nonirradiated subjects. While histologic features were comparable the patient's age at the time of diagnosis was lower and lymph node metastases were more frequent in familial than in nonfamilial cases of papillary thyroid carcinoma from the same region. We conclude that genetic factors can predispose the patient for development of papillary thyroid carcinoma. The high local incidence may be due to interaction between susceptibility gene(s) and environmental factors.

A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples

“…1 Approximately 80% of thyroid carcinomas are papillary carcinomas. 2 Papillary thyroid carcinoma is defined as a malignant tumour showing evidence of follicular differentiation and characterized by distinctive nuclear features. 3 Because papillary structures may occasionally be found in follicular adenoma and follicular thyroid carcinoma, the diagnosis of papillary thyroid carcinoma ultimately depends on its nuclear features, that is ground glass appearance, irregularity of nuclear contours, grooves and pseudo-inclusions.…”

Carcinoma não medular familiar da tiróide

“…Do mesmo modo, a identificação dos genes responsáveis pelo CTNMF possivelmente facilitaria o rastreamento e o diagnóstico precoce da doença, aumentando as taxas de cura e de sobrevida. Analisando as várias famílias acometidas pelo CTNMF relatadas na literatura, observa-se acometimento de vários membros na mesma geração e transmissão por genitores de ambos os sexos (25)(26)(27)(28)(29)(30)(31), o que sugere transmissão genética por padrão de herança autossômico dominante, com penetrância variável.…”

Towards Understanding the Molecular Basis of Thyroid Cancer

“…Thyroid carcinoma has, however, been recognized to be more frequent in such syndromes as Gardner syndrome (adenomatosis polyposis) 73,74 and Cowden disease. 75 In addition, reports of remarkable aggregation of papillary thyroid cancers in families [76][77][78] indicate that genetic factors may be relevant to thyroid follicular cell cancer. Indeed, a recent population study indicates some 3.8% of patients with papillary cancer had similarly affected family members.…”

“…Indeed, a recent population study indicates some 3.8% of patients with papillary cancer had similarly affected family members. 79 Genetic factors appear to be more important in the genesis of papillary carcinoma 76,77,79 compared to follicular carcinomas; thus, a review of the concordance of papillary histology in affected sib pairs. 80,81 Female patients with papillary carcinoma (but not their relatives) are at greater risk for other cancers (including breast, renal and CNS malignancies).…”