Familial pain models: the relationship between family history of pain and current pain experience

Edwards, Patrick W.; Zeichner, Amos; Kuczmierczyk, Andrzej R.; Boczkowski, Judith A.

doi:10.1016/0304-3959(85)90166-6

Cited by 126 publications

(66 citation statements)

References 14 publications

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“…Conversely, patients from two-parent households have greater presumed family support, which may include a stay-at-home parent who is overly attentive to perceived changes and inclined to seek medical attention. The dynamics of a patient's household seemed to play a role in postoperative management in our study, which is consistent with existing literature examining home life, family support, and the quality of home care provided after a medical procedure [9,11,37,57]. These findings support the importance of preoperative assessment of social support and teaching pain management strategies to patients and caregivers (Table 8).…”

Section: Background and Rationalesupporting

confidence: 90%

“…Rather, all patients Table 8. Recommendations for preoperative evaluation [5,11,17,24,25,27,37,42,46,48,49] should be screened for the presence of psychiatric symptoms and appropriate management of these symptoms should be required before planning surgical intervention of this magnitude (Table 8). As the lead team member, the surgeon should be aware of the patient's preexisting mental health condition and the potential impact during treatment.…”

Section: Background and Rationalementioning

confidence: 99%

“…As such, a poor support system and familial and/or environmental problems may compromise postoperative self-care, rehabilitation, and outcome [36,47,52]. Undergoing limb lengthening and reconstruction also requires mental stability, resilience, and good coping skills to manage increasing pain, limited mobility, and treatment fatigue [10,11,15,19,35,41,58]. This is crucial, because unaddressed psychological, emotional, and behavioral disturbances have been shown to complicate rehabilitation [2,20,38,40].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Implications of Psychosocial Factors on Pediatric External Fixation Treatment and Recommendations

Richard

Nguyen

Birch

et al. 2015

Clin Orthop Relat Res

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Background Pediatric limb reconstruction using circular external fixation is a prolonged treatment that interrupts patients' daily function. Patient personality characteristics and expectations may interfere with planned treatment, making complicated medical procedures more challenging. The aims of this study are to identify factors impacting treatment outcome and recommendations for preoperative evaluation and planning. Questions/purposes (1) Are there group differences between patients with and without a preexisting mental health condition(s) in terms of unplanned reoperations? (2) Does the number of surgical procedures before current external fixator placement correlate with the number of unplanned readmissions, unplanned reoperations, and days spent in circular external fixation? (3) Are there group differences between single-compared with two-parent households in terms of inpatient narcotic doses, length of inpatient stay, number of unplanned readmissions, length of readmission(s), and/or unplanned outpatient clinic visits? (4) Does patient age at the time of surgery have an impact on treatment duration, postoperative complications, and treatment outcome? Methods This is a retrospective chart review of pediatric patients who underwent limb reconstruction between 2008 and 2012. Patients with limb length discrepancy [ 4 cm or severe angular deformity and who agreed to intervention were treated with circular external fixation. Sixty-seven patients were included; 16 patients were excluded. Statistical analyses included Pearson r correlation and t-test. Results Patients who reported preexisting mental health diagnosis (13%) had more unplanned reoperations than patients who did not (no mental health diagnosis; 87%) (mental health diagnosis 3.4 ± 10.3 versus no mental health diagnosis 0.2 ± 0.5 reoperation[s], p = 0.022). Number of previous surgical procedures correlated with number of unplanned reoperations (r = 0.448, p \ 0.001), number of unplanned readmissions (r = 0.375, p \ 0.001), and number of days in an apparatus (r = 0.275, p = 0.018). Compared with patients from two-parent households, patients from single-parent households received a greater number of inpatient narcotic doses (singleparent 129 ± 118 versus two-parent 73 ± 109 doses, p = 0.039), longer length of inpatient stay (single-parent 73 ± 63 versus two-parent 40 ± 65 days, p = 0.036), more unplanned readmissions (single-parent 0.4 ± 0.1 versus two-parent 0.2 ± 0.2 readmission, p = 0.024), longer hospitalization when readmitted (single-parent 5 ± 11 versus two-parent 1 ± 3 day(s), p = 0.025), and fewer unplanned outpatient visits (single-parent 0.2 ± 0.8 versus two-parent 0.9 ± 1.1 visit, p = 0.005). Apparatus applications with successful outcome had higher average age than those with poor outcome (successful outcome 16 ± 3 versus poor outcome 13 ± 4 years old, p = 0.011). Age at time of apparatus application correlated with One or more of the authors (JGB, MKS, AMC), or a member of his or her immediate family, has or may receive payments ...

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Section: Background and Rationalesupporting

confidence: 90%

Section: Background and Rationalementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Implications of Psychosocial Factors on Pediatric External Fixation Treatment and Recommendations

Richard

Nguyen

Birch

et al. 2015

Clin Orthop Relat Res

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“…Levels of pain sensitivity have been shown to be similar within families (30). Genetic mechanisms for pain perception have also been demonstrated in animal studies and genetic polymorphisms identified (31,32). However, learned patterns of behavior within families, and shared environmental influences may be the predominant determinants of pain perception and not genetic components (33).…”

mentioning

confidence: 99%

The genetic contribution to carpal tunnel syndrome in women: A twin study

Hakim¹,

Cherkas²,

Zayat³

et al. 2002

Arthritis & Rheumatism

116

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Objective. To assess the relative genetic and environmental contribution to carpal tunnel syndrome (CTS) using a classic twin study of monozygotic (MZ) and dizygotic (DZ) twins. Methods. The study group comprised unselected female twin pairs, between 20 and 80 years of age, from the St Thomas' UK Adult Twin Registry. Individuals completed a questionnaire that included details on potential risk factors for CTS. The diagnosis of CTS was made using a standardized hand pain diagram and validated criteria. The genetic contribution to CTS was assessed using variance component and regression methods, the heritability was adjusted for environmental confounders. The role of individual risk factors was assessed by a nested case-control study.Results. An overall prevalence of 14.2% for CTS was found in a population of 4,488 females, comprising 867 MZ and 970 DZ twin pairs, and 814 singletons. The concordance for CTS was significantly higher in MZ compared with DZ twins (case-wise concordance values of 0.35 and 0.24 respectively, with a significantly increased MZ:DZ ratio of 1.48; P ‫؍‬ 0.03). Modeling produced a heritability estimate of 0.46 (95% CI 0.34 -0.58) that was essentially unchanged after adjustment for environmental risk factors including age, body mass index, physical activities, and hormonal/reproductive factors. No major influence of any individual risk factor was seen in the case-control analysis of 520 cases and 3,154 controls, apart from a modest association with menopausal status with an increased risk of 1.53 and 1.43 in the peri and postmenopausal groups. There was no overall effect of age or body mass index. Conclusion. This is the first study to explore the genetic component of CTS. Our data show that up to half of the liability to CTS in women is genetically determined, and this appears to be the single strongest risk factor, with only minor contributions from known environmental factors. Further studies should focus on genetic mechanisms that may lead to tests for susceptibility and detection of those at risk of developing CTS.

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“…Evidências sugerem a presença de fatores genéticos, em combinação com mecanismos de dor periféricos e/ou centrais, envolvidos no desenvolvimento da dor crônica e difusa relatada pelos pacientes (3,(12)(13)(14)(15) . Trabalhos em animais e seres humanos demonstraram a presença de fatores familiares influenciando significativamente a sensibilidade dolorosa, podendo estar, pelo menos em parte, associada a influências genéticas relacionadas ao sexo na transmissão ou modulação da dor (16)(17)(18)(19)(20)(21)(22) . Na FM, de acordo com modelo etiopatogênico proposto (23,24) , a sensibilidade dolorosa anormal depende de uma suscetibilidade genética e envolve os eixos neuroendócrinos, incluindo o eixo hipotálamo-hipófise-adrenal (HPA), assim como defeitos estruturais específicos no sistema musculoesquelético e sistema nervoso central (SNC).…”

Section: Introductionunclassified

Avaliação da produção de espécies reativas de oxigênio por granulócitos de sangue periférico de pacientes com fibromialgia primária

Souza¹,

Nogueira-Machado²,

Silva³

et al. 2003

Rev. Bras. Reumatol.

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RESUMOObjetivo: avaliar anormalidades bioquímicas que possam estar relacionadas à fibromialgia, mais especificamente o metabolismo oxidante de granulócitos de pacientes com fibromialgia primária (FMP). Métodos: foram selecionados 10 pacientes (9 mulheres e 1 homem) portadores de FMP, com idade entre 20 e 40 anos, de acordo com os critérios do Colégio Americano de Reumatologia, que não apresentavam qualquer outra doença de curso agudo ou crônico e estavam sem utilizar medicamentos no mínimo durante duas semanas. Controles normais (n = 19) pareados por sexo e idade foram selecionados. Os granulócitos de pacientes e controles foram separados do sangue periférico e utilizados como célula de trabalho. A produção de espécies reativas de oxigênio (ERO) foi determinada por meio de ensaio de quimioluminescência dependente de luminol. Resultados: demonstramos, pela primeira vez, uma produção significantemente elevada de ERO (3,2 vezes maior) em granulócitos de sangue periférico de pacientes com FMP (p < 0,05). Conclusões: estes resultados demonstraram um comportamento anormal dos granulócitos de pacientes com FMP, em que uma produção aumentada de espécies reativas do oxigênio foi observada. Estudos futuros serão necessários para melhor esclarecer estes resultados, delineando uma nova perspectiva na compreensão e abordagem destes pacientes.

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Familial pain models: the relationship between family history of pain and current pain experience

Cited by 126 publications

References 14 publications

Clinical Implications of Psychosocial Factors on Pediatric External Fixation Treatment and Recommendations

Clinical Implications of Psychosocial Factors on Pediatric External Fixation Treatment and Recommendations

The genetic contribution to carpal tunnel syndrome in women: A twin study

Avaliação da produção de espécies reativas de oxigênio por granulócitos de sangue periférico de pacientes com fibromialgia primária

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