Familial Pityriasis Rubra Pilaris: Case Report and Review

Abstract

BACKGROUND Constriction bands around the digits are termed as ainhum; those which mimic ainhum are termed as pseudoainhum. Ainhum and pseudoainhum can cause autoamputation of the digits. Ainhum which is of idiopathic origin is common in Negros, but rare in rest of the world. Many hypotheses were promulgated for the aetiology of pseudoainhum; however, it has been associated with hereditary palmoplantar keratodermas, systemic sclerosis, leprosy, psoriasis, vascular anomalies etc. We report a case of pseudoainhum associated with pityriasis rubra pilaris (PRP), which has not been reported in the literature so far.

Ustekinumab as an Alternative Treatment Option for Chronic Pityriasis Rubra Pilaris

“…The exact mechanism how ustekinumab works is unclear; however, it is believed that blocking of the p40 subunits of IL-12 and IL-23 reduces additional cytokine release, thus removing a crucial step for immune cell activation. This therapy has been found to be successful in patients with psoriasis [ 6 ] and due to the aforementioned similarities, it has infrequently been used for patients with unremitting PRP (table 1 ) [ 4 , 7 , 8 , 9 ].…”

Increased epidermal expression and absence of mutations inCARD14in a series of patients with sporadic pityriasis rubra pilaris

“…Although most cases of PRP are sporadic, rare familial cases of PRP have been reported . The latter form of PRP is inherited in an autosomal dominant fashion with partial penetrance.…”

In Vitro and Randomized Controlled Clinical Study of Natural Constituents’ Anti-HPV Potential for Treatment of Plantar Warts Supported with In Silico Studies and Network Analysis

“…Metabolomic profiling assisted by HR-LCMS analysis of the crude extract Nigella sativa seed (Table S1, Figures S7-S9) led to the identification of a wide range of secondary metabolites belonging to different phytochemical classes such as Nigellimine (1) [28], Nigellimine N-oxide (2) [29], 3,7-Dimethyl-6-octen-1-ol (3) [30], Nigeglanine (4) [31], Salfredin B 11 (5) [32], Nigellicine (6) [33], 6-Octadecenoic acid (7) [34], Nigellidine (8) [35], Nigellidine 1-O-Sulfate (9) [36], Nigellamine C (10) [37], Nigellamine A 4 (11) [37], Nigellamine A 3 (12) [37], Nigellamine A 1 (13) [38], Nigellamine A 5 (14) [37], and Nigellamine B1 (15) [38]. Furthermore, profiling of the crude extract of Musa Acuminata peel resulted in the identification of several metabolites with different chemical classes such as 28-Hydroxy-7octacosanone (16) [39], musabalbisiane A (17) [40], 2-hydroxyperinaphthenone (18) [41], naproxen (19) [42], 4-phenyl-1H,3H-naphtho [1,8-cd]pyran-1,3-dione (20) [41], 2-methoxy-9-phenyl-1H-phenalen-1-one (21) [41], musafluorone (22) [43], 9-(4-Hydroxyphenyl)-2methoxy-1H-phenalen-1-one (23) [41], 9-(3,4-dimethoxyphenyl)-2-methoxy-1H-phenalen-1one (24) [44], bisanigorufone (25) [45], anigorootin (26), 4 ′ -Hydroxyanigorootin (27)…”

“…Warts frequently appear on the balls and heels of the feet, as these areas experience the most pressure. Even though these warts are benign, they can cause pain, difficulties walking, and high chances of transmission [ 7 , 8 ]. Patients with warts seek a durable therapy to avoid recurrent visits to physicians.…”