2021
DOI: 10.1111/trf.16440
|View full text |Cite
|
Sign up to set email alerts
|

Familial pseudohyperkalemia induces significantly higher levels of extracellular potassium in early storage of red cell concentrates without affecting other standard measures of quality: A case control and allele frequency study

Abstract: Background Familial pseudohyperkalemia (FP) is characterized by an increased rate of potassium leakage in refrigerated red cells and is associated with the minor allele of the single nucleotide polymorphism rs148211042 (R723Q) in the ABCB6 gene. The study aims were to obtain the minor allele frequencies of ABCB6 variants and to measure supernatant potassium accumulation, and other red cell storage parameters, in red cell concentrates (RCC) from carriers of variant rs148211042 under standard blood bank conditio… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
13
0
2

Year Published

2022
2022
2023
2023

Publication Types

Select...
7

Relationship

3
4

Authors

Journals

citations
Cited by 9 publications
(16 citation statements)
references
References 43 publications
1
13
0
2
Order By: Relevance
“…To our knowledge, the degree of reticulocyte maturation in DHSt RBC has yet to be analyzed. It is not anticipated that FP RBCs will have a reticulocyte maturation defect as FP is a benign, asymptomatic condition [ 132 ]. Together the study of reticulocyte maturation in HSt variant RBCs provided an insight into the reticulocyte maturation process and a better understanding of the effect of HSt variants on RBC maturation.…”
Section: Red Cell Membrane Variantsmentioning
confidence: 99%
“…To our knowledge, the degree of reticulocyte maturation in DHSt RBC has yet to be analyzed. It is not anticipated that FP RBCs will have a reticulocyte maturation defect as FP is a benign, asymptomatic condition [ 132 ]. Together the study of reticulocyte maturation in HSt variant RBCs provided an insight into the reticulocyte maturation process and a better understanding of the effect of HSt variants on RBC maturation.…”
Section: Red Cell Membrane Variantsmentioning
confidence: 99%
“…Unfortunately, we were not able to conduct a thorough survey of her pedigree; The heterozygous R723Q SNP (rs148211042) was reported as present in approximately 1: 500 UK donors and the R375W SNP (rs764893806) is thought to be present in approximately 1:35,000 UK donors; the variant R276W was present in 0.3% (1/327) of blood donors from South Italy ( 21 ). The estimated accumulative frequencies of FP individuals are 1/785 in Asian population ( 22 ). Since few FP cases have been reported in Asia, FP prevalence might be substantially understated.…”
Section: Discussionmentioning
confidence: 99%
“…Two healthy controls were sex‐ and age‐matched to each FP individual. The five FP individuals participating in this study were different from our previous study of FP RBC 9 …”
Section: Methodsmentioning
confidence: 99%
“…The minor allele frequency of this variant in Britons with European ancestry was found to be 1 in 788 from screening different genotyped population cohorts. As this is a dominantly inherited condition, this results in 1:394 individuals in the British population with FP 9 . The rise in supernatant potassium concentration over cold blood storage of RBC from carriers of variant rs148211042 has been previously studied within our group 9 .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation