Familial resemblance for free androgens and androgen glucuronides in sedentary black and white individuals: the HERITAGE Family Study. Health, Risk Factors, Exercise Training and Genetics

Hong, Yuling; Gagnon, Jacques; Rice, Treva; Pérusse, Louis; Leon, AS; Skinner, J. S.; Jh, Wilmore; Bouchard, Claude; Rao, D. C.

doi:10.1677/joe.0.1700485

Cited by 43 publications

(30 citation statements)

References 22 publications

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“…The sex difference in heritability has also been found for several other traits 9. In addition, previous studies also found a higher heritability of testosterone, IgA, IgE, IgG and IgM levels in males than females 14 22. It is likely that there may be shared common causes between metabolic syndrome and immunity response.…”

Section: Discussionmentioning

confidence: 76%

Heritability of metabolic syndrome traits among healthy younger adults: a population based study in China

Luo

et al. 2009

Journal of Medical Genetics

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OBJECTIVE To estimate heritability of metabolic syndrome traits among healthy younger adults in a human population in China, and examine potential sex differences in heritability and parental effect on metabolic syndrome traits. METHODS Using offspring-parent regression, we estimated heritability (h(2)) of metabolic syndrome traits based on 452 child-parent triads identified from a population based random survey on metabolic syndrome among people over 15 years of age in Guangzhou, China. RESULTS Body mass index (BMI), cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG) and waist circumference (waist-C) were more heritable (h(2), 0.42-0.545), whereas systolic blood pressure (SBP), diastolic blood pressure (DBP), and triglycerides (TG) were less heritable (h(2), 0.14-0.28). Sons had pronounced increases in heritability for all traits over daughters, particularly for cholesterol (0.653 vs 0.356), FPG (0.602 vs 0.313), LDL-C (0.521 vs 0.329), and TG (0.395 vs 0.187). Offspring-mother seemed to have a higher heritability in every trait except FPG (0.67 vs 0.794) than offspring-father, most notably for DBP (0.308 vs 0.122), SBP (0.288 vs 0.146), TG (0.387 vs 0.239) and waist-C (0.581 vs 0.354). CONCLUSION We estimated the heritability of metabolic syndrome traits in a human population based on a unique population based offspring-parent sample from China, and found important evidence that the maternal and paternal effects on these traits are different and the sex difference in heritability is pronounced.

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Section: Discussionmentioning

confidence: 76%

Heritability of metabolic syndrome traits among healthy younger adults: a population based study in China

Luo

et al. 2009

Journal of Medical Genetics

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“…Baseline testosterone has fairly high heritability. The majority of estimates are between 50 percent and 70 percent with a mean of 60 percent (e.g., Gagnon et al 2001;Harris and Vernon et al 1998).…”

Section: Primer On Testosteronementioning

confidence: 99%

Testosterone and Social Behavior

et al. 2006

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Popular perceptions of the effect of testosterone on "manly" behavior are inaccurate. We need to move away from such simplistic notions by treating testosterone as one component along with other physiological, psychological and sociological variables in interactive and reciprocal models of behavior. Several hormones can now be measured in saliva, removing the need for blood samples. Conceptual shifts have moved research from biological determinism to biosocial models in which the social environment plays a key role in understanding behavior-hormones associations. As a result, more social scientists are incorporating testosterone in their studies. Following a primer on testosterone, we describe testosterone's link to (a) gaining, maintaining and losing social status, (b) aggression and antisocial behavior, (c) peer and family relationships, and (d) gender similarities and differences. Research needed to take us to the next level of understanding is outlined."Testosterone poisoning," now part of the language, is a popular explanation for excessive "manly" behaviors such as boasting, violence and pugnaciousness. Middie-aged and older men think sagging libido and fatigue stem from their declining testosterone.In fact, there is little empirical support for these popular assertions. We cannot say that they are all false because research literature is not conclusive. But it is already clearthat there is no simple one-to-one relationship between testosterone and machoism or aggressiveness or sexuality (Mazur and Booth 1998). It seems wiser to view testosterone as one component in a confluence of interacting physiological, psychological and social influences that affect behavior.The focus of this research is variables of interest to sociologists. Gaining, maintaining and losing status is a theme found in a great deal of sociological research. Many testosterone studies have focused on status change under the rubric of competition. Sociologists who focus on deviance and social integration will be interested in testosterone studies that focus on problem behavior, and the nature and quality of peer and family relations. Those who work in the area of health and social behavior will find studies of testosterone's link to depression. Those who study gendered behavior will be interested in the differences and symmetries in the links between testosterone and social behavior for males and females. Finally, sociologists will be interested to learn that the social environment has a key role in defining testosterone-behavioral links.This article is dedicated to the memory of James M. Dabbs, apioneer in the field of testosterone research who greatly enriched our knowledge methodologically and substantively.

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“…For example, the heritability of neuroticism, a personality trait, was estimated to range from 13 to 58% [18] . In men, heritability estimates are in the range of 25-75% for testosterone [19][20][21][22][23][24] . Some traits, such as height and hemoglobin concentration, have heritability of 80% or above [25,26] .…”

Section: Simulation Designmentioning

confidence: 99%

Phenotypically Enriched Genotypic Imputation in Genetic Association Tests

2016

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Background: In longitudinal epidemiological studies there may be individuals with rich phenotype data who die or are lost to follow-up before providing DNA for genetic studies. Often, the genotypic and phenotypic data of the relatives are available. Two strategies for analyzing the incomplete data are to exclude ungenotyped subjects from analysis (the complete-case method, CC) and to include phenotyped but ungenotyped individuals in analysis by using relatives' genotypes for genotype imputation (GI). In both strategies, the information in the phenotypic data was not used to handle the missing-genotype problem. Methods: We propose a phenotypically enriched genotypic imputation (PEGI) method that uses the EM (expectation-maximization)-based maximum likelihood method to incorporate observed phenotypes into genotype imputation. Results: Our simulations with genotypes missing completely at random show that, for a single-nucleotide polymorphism (SNP) with moderate to strong effect on a phenotype, PEGI improves power more than GI without excess type I errors. Using the Framingham Heart Study data set, we compare the ability of the PEGI, GI, and CC to detect the associations between 5 SNPs and age at natural menopause. Conclusion: The PEGI method may improve power to detect an association over both CC and GI under many circumstances.

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Familial resemblance for free androgens and androgen glucuronides in sedentary black and white individuals: the HERITAGE Family Study. Health, Risk Factors, Exercise Training and Genetics

Cited by 43 publications

References 22 publications

Heritability of metabolic syndrome traits among healthy younger adults: a population based study in China

Heritability of metabolic syndrome traits among healthy younger adults: a population based study in China

Testosterone and Social Behavior

Phenotypically Enriched Genotypic Imputation in Genetic Association Tests

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