Familial restless legs with periodic movements in sleep

Montplaisir, J; Godbout, Roger; Boghen, Dan; deChamplain, Jacques; Young, Simon N.; Lapierre, G.

doi:10.1212/wnl.35.1.130

Cited by 130 publications

(45 citation statements)

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“…However, periodic leg movements of sleep have a larger intermovement interval (4-90 seconds [8] as compared with the 2-3 seconds in our case), and decrease in the deeper phases of non-rapid eye movement and rapid eye movement sleep [2], in contrast with our case, which shows no variability throughout the sleep cycle.…”

Section: (A) Axial Plane Through the Medulla Demonstrating An Increacontrasting

confidence: 57%

“…ing infants that have been described in the literature [1,8] all had a clear family history, increased sleep latency, disturbed sleep, and the complains were irregular in the first years. The absence of sleep disturbances, no family history of the condition, and persistent character from onset, further rule out the diagnosis of restless legs syndrome for our patient.…”

Section: (A) Axial Plane Through the Medulla Demonstrating An Increamentioning

confidence: 99%

“…The periodicity of the movements during sleep can remotely evoke the periodic leg movements of sleep, which are known to persist throughout wakefulness [8]. However, periodic leg movements of sleep have a larger intermovement interval (4-90 seconds [8] as compared with the 2-3 seconds in our case), and decrease in the deeper phases of non-rapid eye movement and rapid eye movement sleep [2], in contrast with our case, which shows no variability throughout the sleep cycle.…”

Section: (A) Axial Plane Through the Medulla Demonstrating An Increamentioning

confidence: 99%

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Involuntary rhythmic leg movements time-locked with the respiratory cycle

Leal

Calado

2001

Pediatric Neurology

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Involuntary rhythmic leg movements in childhood is an uncommon condition, the generators of which remain unknown. We report on a male 3 years of age with distinct features providing important clues concerning the location of one of these generators. At the age of 7 months, the previously healthy young male started with low frequency, rhythmic, and continuous (both during wakefulness and sleep) flexion/extension movements of the lower limbs. Movements interfered significantly with gait acquisition, and, despite normal cognitive development, he was able to walk only at age 2 years, 4 months. The neurologic examination revealed the absence of automatic stepping in the neonatal period, but was otherwise normal. A polygraphic electroencephalogram/electromyogram (EEG/EMG) recording, at the age of 2 years, 9 months, revealed rhythmic and synchronous legs with EMG activity at 0.5 Hz. A more complete polygraphic recording at the age of 3 years, 10 months, showed a lower frequency (0.35 Hz) for the movements, which were time-locked with the respiratory cycle. Magnetic resonance imaging (MRI) of the brain revealed an increased T 2 signal in the upper medulla-lower pons regions. The generator of the rhythmic legs movements is postulated to be the respiratory center, connecting with the reticulospinal projecting neurons through an aberrant pathway.

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Section: (A) Axial Plane Through the Medulla Demonstrating An Increacontrasting

confidence: 57%

Section: (A) Axial Plane Through the Medulla Demonstrating An Increamentioning

confidence: 99%

Section: (A) Axial Plane Through the Medulla Demonstrating An Increamentioning

confidence: 99%

See 1 more Smart Citation

Involuntary rhythmic leg movements time-locked with the respiratory cycle

Leal

Calado

2001

Pediatric Neurology

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“…6 However, in some cases, RLS-NM may be associated with an early peripheral nervous system involvement such as seen in our patients with FAP. In view of this, patients with apparently idiopathic, late onset RLS should be thoroughly investigated to discover a possible underlying cause, particularly if there is a family history.…”

mentioning

confidence: 54%

Restless legs syndrome and nocturnal myoclonus: initial clinical manifestation of familial amyloid polyneuropathy.

Salvi

Montagna

Plasmati³

et al. 1990

Journal of Neurology, Neurosurgery & Psychiatry

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“…A SPI também costuma acompanhar-se das seguintes características clínicas: 1-distúrbios do sono e suas consequências; 2-movimentos involuntários (movimentos periódicos dos membros durante o sono, movimentos involuntários dos membros em vigília e ao repouso); 3-exame neurológico normal; 4-curso clínico apresentando início em qualquer idade, com acometimento mais intenso em pacientes de meia idade e de idade avançada, podendo ter quadro estático ou ainda progressivo; 5-história familiar, sugestiva de herança autossômica dominante 3,6 .…”

Section: Discussionunclassified

Síndrome das pernas inquietas com herança autossômica dominante piorada pelo uso de mirtazapina: relato de caso

Teive

Quadros

Barros

et al. 2002

Arq. Neuro-Psiquiatr.

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RESUMO -Relatamos o caso de uma paciente de 78 anos, com diagnóstico estabelecido de síndrome das pernas inquietas (SPI), de etiologia primária com herança autossômica dominante. A paciente apresentava quadro depressivo associado. Enfatiza-se a piora do quadro clínico da SPI após o uso de anti-depressivo com ação inibidora seletiva da recaptação de serotonina (mirtazapina), com atenuação dos sintomas após a retirada da droga, e a excelente resposta terapêutica com o uso de agonista dopaminérgico (pramipexol) em baixa dose. PALAVRAS-CHAVE: síndrome das pernas inquietas, mirtazapina.Worsening of autosomal dominant restless legs syndrome after use of mirtazapine: case report ABSTRACT -We report the case of a 78 years old female patient with primary restless legs syndrome (RLS) with an autosomal dominant pattern of inheritance. In addition, the patient also had depression. We emphasize the worsening of symptoms of RLS after the use of a selective serotonin uptake inhibitor (mirtazapine), with improvement after the drug was discontinued, and an excellent recovery with the use of low dose dopaminergic agonist (pramipexol).KEY WORDS: restless legs syndrome, mirtazapine. . Um grande interesse nesta enfermidade vem sendo observado recentemente, talvez pela sua alta incidência, de até 5%, na população em geral segundo alguns estudos 1,2,4 . A falta de informação dirigida aos médicos e também o fato da sua fisiopatologia ser ainda pouco compreendida contribuem para que seja uma doença sub-diagnosticada. É caracterizada, sumariamente, pela sensação de inquietude, noturna e ao descanso, dos membros inferiores, associados a queixas de parestesias e disestesias. A insônia é uma consequência comum destes sintomas. Trata-se de doença crônica, com maior prevalência acima dos 30 anos de idade [1][2][3][4] . Porém, pode ocorrer em todas as faixas etárias. A classificação da SPI ainda é motivo de controvérsia, sendo basicamente dividida em duas categorias: idiopática (primária) e sintomática (secundária). Nas formas primá-rias pode-se encontrar formas familiares com herança autossômica dominante 1,3,4 . Neste artigo relatamos um caso da SPI com herança autossômica dominante, bem como peculiaridades do tratamento, em particular a piora do quadro clínico após o uso de droga inibidora seletiva de captação de serotonina (mirtazapina) e a excelente melhora clínica após tratamento com droga agonista dopaminérgico (pramipexol). CASOMulher, branca, com 78 anos de idade, viúva. Há 2 meses começou apresentar sensação de desconforto e parestesias nos pés, pernas e coxas, semelhantes a "formigamento", "queimação". Esses sintomas pioravam com a

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Familial restless legs with periodic movements in sleep

Cited by 130 publications

References 0 publications

Involuntary rhythmic leg movements time-locked with the respiratory cycle

Involuntary rhythmic leg movements time-locked with the respiratory cycle

Restless legs syndrome and nocturnal myoclonus: initial clinical manifestation of familial amyloid polyneuropathy.

Síndrome das pernas inquietas com herança autossômica dominante piorada pelo uso de mirtazapina: relato de caso

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