Familial reticulate acropigmentation of Dohi

Reticulate Acropigmentation of Dohi: First Case Reports from Nepal

“…Initially, this clinical entity was considered to be a Japanese/Korean specific dermatosis, but similar cases have been reported in Europe, Italy, and India (1, 10, 12, 13). To the best of our knowledge, our two cases represent the first case reports of RAD from Nepal.…”

“…Reticulate acropigmentation (RA) is a dyschromatic disorder with an autosomally dominant pattern of inheritance. Two main forms of RA have been described: 1) Reticulate acropigmentation of Kitamura (RAK) and 2) Reticulate acropigmentation of Dohi (RAD) (1). The later is also known as dysch‐romatosis symmetrica hereditaria (2).…”

Dyschromatosis symmetrica hereditaria: report of a sporadic case

“…At present, more than 60 mutations of this gene have been reported, most of them in oriental individuals who suffer from DSH, but it is not possible to establish a clear correlation between the clinical phenotype and the type of mutation of the DSRAD 12–17 gene. Rare spontaneous cases and cases of autosomal recessive type have been described, mainly in the West 2,7 . Even though it was primarily described as a genodermatosis specific to the oriental race, similar conditions have been reported on people of other races 2,7,18,19 .…”

“…Rare spontaneous cases and cases of autosomal recessive type have been described, mainly in the West 2,7 . Even though it was primarily described as a genodermatosis specific to the oriental race, similar conditions have been reported on people of other races 2,7,18,19 . There are only two previous cases in South America reported in the literature 9,19…”

“…DSH is a genodermatosis characterized by the presence of lentigines at the face, and punctiform hypo‐ and hyper‐pigmented macules at the back of hands and feet; they are asymptomatic, they appear in the first years of childhood and accentuate – but not enlarge – with the passing of time until it stops at adolescence 3 . Such lesions adopt a reticular pattern and they can affect flexural areas, neck and rarely the scrotum and scalp 7 . In general, they are not accompanied by systemic involvement, neither is there evidence of photosensitivity.…”