Familial Retrocaecal Appendicitis

Shperber, Y; Halevy, Ariel; Oland, Jan; Orda, Ruben

doi:10.1177/014107688607900708

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…Increased risks for appendicitis were described mainly as low-fibre diet (Burkitt 1971;Adamis et al 2000), infections due to edema causing obstruction of appendix lumen and hereditary (Andersson et al 1979). Familiar history of appendicitis is considered to be due a particular position of the appendix, which predisposes it to infection (Shperber et al 1986). However, irregular myenteric ganglia distribution with currently unknown relation to appendix position may also be hereditary.…”

Section: Discussionmentioning

confidence: 99%

Atypical localization of myenteric ganglia in the human appendical wall: a comparative study with animal appendix

Kubíková¹,

Sivakova²,

Perzelova³

2014

Biologia

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The presence of well developed appendices in some animals when compared to humans has led to speculation that appendix is a vestigial organ. Increasing number of studies have revealed that the appendix serves as an important organ in humans. The function of animal appendix, and the differences between species remain poorly understood. In this study we examined human myenteric plexus and compared them with animal studies. Appendices were obtained from five young adults in which the appendix was found to be normal after removal. Fixed appendix cryosections were examined by immunofluorescence methods using neuronal marker antibodies to neurofilaments and beta III tubulin. Both antibodies stained myenteric ganglia which were arranged in an apparently irregular pattern in human appendix wall. We observed unexpected localization of myenteric ganglia in the subserosa often accompanied by rarely occurring ganglia in the longitudinal muscle layer. These ganglia were of different sizes and shapes and unequally distributed under a thin layer of serosa. Our findings raise many questions about the possible role of irregular and atypical myenteric ganglia localization in relation to altered motility and subsequent pathogenesis of the appendix in inflammatory disease in humans. On the other hand, studies of the literature have revealed simplicity in the organization of myenteric plexus, e.g., in well-developed rabbit appendix. In addition, appendicitis in animals is restricted to in apes with similarly shaped appendix to humans.

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Section: Discussionmentioning

confidence: 99%

Atypical localization of myenteric ganglia in the human appendical wall: a comparative study with animal appendix

Kubíková¹,

Sivakova²,

Perzelova³

2014

Biologia

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“…Although the presence of such ac ongenital malformation alone is not sufficient to precipitateanattack of acute appendicitis, it could well be considered as apredisposing factor in that it presentsthe mechanism by which the lumen of the appendix could be obstructed. Various anomalies of the appendix, such as missing section of mesoappendixo rm orphological and anatomical variationsi ncluding ac oiled, short, longo rr etrocaecal appendix (15)(16)(17) described by many authors. Some authors also suggested that anatomical variations of the appendix might be inheritedasasimple dominant unit-character (15,17).…”

Section: Familyhistorymentioning

confidence: 99%

Heredity and Familial Tendency of Acute Appendicitis

Ergül

2007

Scand J Surg

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Background: Althoughinflammatory disease of the vermiformappendix has been recognized as such for morethan 100 years, its etiology remains asubject of controversy.The notionthat appendicitisisfamilial, is not only important for understandingthe etiology of the condition but might contribute substantially to the diagnosis and thus provide an indication for early surgical intervention.Methods: An extensiveMedline search, textbooks, scientific reportsand scientific journals are the data sources.Conclusions: In the light of past studies, we can suggest that almost half of the variability in risk of acute appendicitis is due to genetic factors. Ap ositive family history increases the relative risk of beingacute appendicitisnearly 3times.

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“…A retrocecal appendix is common and one series showed the appendix to be retrocolic and retrocecal in 58% of cases [1] . A retrocecal appendix has been described also in families and is thought to be inherited as a simple dominant unit character [11] . Studies of the fetal appendix, however, show that it is almost always subcycle during this period [12] .…”

Section: Discussionmentioning

confidence: 99%

Ascending retrocecal appendicitis presenting with right upper abdominal pain: Utility of computed tomography

Ong¹,

Venkatesh²

2009

WJG

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Acute appendicitis is a common surgical condition that is usually managed with early surgery, and is associated with low morbidity and mortality. However, some patients may have atypical symptoms and physical findings that may lead to a delay in diagnosis and increased complications. Atypical presentation may be related to the position of the appendix. Ascending retrocecal appendicitis presenting with right upper abdominal pain may be clinically indistinguishable from acute pathology in the gallbladder, liver, biliary tree, right kidney and right urinary tract. We report a series of four patients with retrocecal appendicitis who presented with acute right upper abdominal pain. The clinical diagnoses at presentation were acute cholecystitis in two patients, pyelonephritis in one, and ureteric colic in one. Ultrasound examination of the abdomen at presentation showed subhepatic collections in two patients and normal findings in the other two. Computed tomography (CT) identified correctly retrocecal appendicitis and inflammation in the retroperitoneum in all cases. In addition, abscesses in the retrocecal space (n = 2) and subhepatic collections (n = 2) were also demonstrated. Emergency appendectomy was performed in two patients, interval appendectomy in one, and hemicolectomy in another. Surgical findings confirmed the presence of appendicitis and its retroperitoneal extensions. Our case series illustrates the usefulness of CT in diagnosing ascending retrocecal appendicitis and its extension, and excluding other inflammatory conditions that mimic appendicitis.

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Familial Retrocaecal Appendicitis

Abstract: Four members of the same family operated on for acute retrocaecal appendicitis are reported. It is suggested that they provide further support for the hypothesis that an hereditary factor might be involved in the pathogenesis of acute appendicitis.

Cited by 10 publications

References 8 publications

Atypical localization of myenteric ganglia in the human appendical wall: a comparative study with animal appendix

Atypical localization of myenteric ganglia in the human appendical wall: a comparative study with animal appendix

Heredity and Familial Tendency of Acute Appendicitis

Ascending retrocecal appendicitis presenting with right upper abdominal pain: Utility of computed tomography

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