Familial risk among Japanese patients with endometriosis

Kashima, Katsunori; Ishimaru, Tadayuki; Okamura, Hitoshi; Suginami, Hiroshi; Ikuma, K; Murakami, Takashi; Iwashita, Mitsutoshi; Tanaka, Kenichi

doi:10.1016/s0020-7292(03)00340-0

Cited by 43 publications

(35 citation statements)

References 16 publications

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“…In the present sample, 5.3% of patients had affected relatives. Studies have shown endometriosis rates of 4.8% to 8.8% in sisters of affected patients 10,[30][31][32][33][34] , and twin studies have shown concordance rates twice as high in monozygotic twins than in dizygotic pairs 35 . The main symptom reported was dysmenorrhea (62.2%).…”

Section: Discussionmentioning

confidence: 99%

Aspectos epidemiológicos e clínicos da endometriose pélvica: uma série de casos

Bellelis¹,

Dias²,

Podgaec³

et al. 2010

Rev. Assoc. Med. Bras.

135

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Section: Discussionmentioning

confidence: 99%

Aspectos epidemiológicos e clínicos da endometriose pélvica: uma série de casos

Bellelis¹,

Dias²,

Podgaec³

et al. 2010

Rev. Assoc. Med. Bras.

135

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“…Among which, Immunological theory is gained more importance than other theory. [4][5][6][7][8][9] This disease leads to lot of economical burden due to medical and surgical management. 10 There is also economical loss due to loss of working hours.…”

Section: Introductionmentioning

confidence: 99%

Cohort study of endometriosis in south Indian district

Rajeswari

Ramanidevi

Kadalmani

2016

Int J Reprod Contracept Obstet Gynecol

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“…11 The relative risk of endometriosis in female siblings of the case subjects is estimated to be 5.7 in Japanese. 12 In addition, evidence of genetic risk of endometriosis has been suggested by twin studies showing increased concordance rates of the development of endometriosis in monozygotic twins 13,14 compared with dizygotic twins. The heritability of human endometriosis was estimated at 51%.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population

et al. 2010

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To identify susceptibility genes for endometriosis in Japanese women, genome-wide association (GWA) analysis was performed using two case-control cohorts genotyped with the Affymetrix Mapping 500K Array or Genome-Wide Human SNP Array 6.0. In each of the two array cohorts, stringent quality control (QC) filters were applied to newly obtained genotype data, together with previously analyzed data from the Japanese Integrated Database Project. After QC-based filtering of samples and single nucleotide polymorphisms (SNPs) in each cohort, 282 838 SNPs in both genotyping platforms were tested for association with endometriosis using a meta-analysis of the two GWA studies with 696 patients with endometriosis and 825 controls. The meta-analysis revealed that a common susceptibility locus conferring a large effect on the disease risk was unlikely. On the other hand, an excess of SNPs with P-values o10 À4 (36 vs 28 SNPs expected by chance) was observed in the meta-analysis. Of note, four of the top five SNPs with P-values o10 À5 were located in and around IL1A (interleukin 1a), which might be a functional candidate gene for endometriosis. Further studies with larger case-control cohorts will be necessary to elucidate the genetic risk factors.

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Familial risk among Japanese patients with endometriosis

Abstract: These data demonstrate a familial tendency for endometriosis and suggest that endometriosis has a genetic factor in the pathogenesis.

Cited by 43 publications

References 16 publications

Aspectos epidemiológicos e clínicos da endometriose pélvica: uma série de casos

Aspectos epidemiológicos e clínicos da endometriose pélvica: uma série de casos

Cohort study of endometriosis in south Indian district

Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population

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