Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database

Family history of haematopoietic malignancies and non-Hodgkin's lymphoma risk in the California Teachers Study

“…Our cohort study results confirm the evidence from populationbased case -control studies and registry-based linkage studies of an increased NHL risk among individuals with a family history of haematopoietic malignancy (Pottern et al, 1991;Zhu et al, 1998;Chiu et al, 2004;Altieri et al, 2005;Chang et al, 2005;Goldin et al, 2005). The magnitudes of our RR estimates are closer to those from registry-based studies, in which family history data are verified, than to those from case -control studies, in which family history is generally self-reported and, therefore, subject to misclassification and recall bias.…”

“…Among 121 216 women participating in the prospective California Teachers Study, NHL risk varied by type of haematopoietic malignancy and gender of the relative. Evidence from epidemiologic studies shows that the risk of nonHodgkin's lymphoma (NHL) is increased by approximately twofold for individuals with a first-degree family history (parent, sibling or child) of haematopoietic malignancy (Pottern et al, 1991;Zhu et al, 1998;Chiu et al, 2004;Altieri et al, 2005;Chang et al, 2005;Goldin et al, 2005;Wang et al, 2007). However, the underlying mechanisms are poorly understood.…”

The non-Hodgkin lymphomas: A review of the epidemiologic literature

“…They reported nonsignificantly increased relative risks of developing NHL among all first-degree family members (SIR 5 1.71, 95% CI: 0.94-2.87) and siblings (SIR 5 2.16, 95% CI: 0.45-6.31) of lymphoma probands. Similarly, Altieri et al 474 using the nationwide Swedish FamilyCancer Database, reported a significantly increased relative risk of NHL among the offspring of persons with NHL (SIR 5 1.8, 95% CI: 1.4-2.2) and in siblings of persons with NHL (SIR 5 1.9, 95% CI: 1.1-3.2). For a parental history of histopathologically concordant lymphoma, the strongest associations with lymphoma risk among offspring were found for B-cell lymphoma (SIR 5 11.8, 95% CI: 2.2-34.8) and follicular lymphoma (SIR 5 6.1, 95% CI: 1.1-18.0).…”

Familial aggregation of lymphoplasmacytic lymphoma with non-Hodgkin lymphoma and other neoplasms

“…1 Lymphoplasmacytic lymphoma/immunocytoma (LPL) is a rare form of B-cell NHL, arising from plasma cells, characterized by high serum levels of monoclonal immunoglobulins with cryoglobulinemia and usually bone marrow infiltration of small lymphocytes showing evidence of plasmacytoid or plasma-cell differentiation. 2 The term Waldenströ m macroglobulinemia (WM) refers specifically to LPL patients with an exceeding and widely variable serum level of monoclonal IgM.…”