1988
DOI: 10.1001/archpsyc.1988.01800340011001
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Familial Risk of Dementia Associated With a Biologic Subtype of Alzheimer's Disease

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Cited by 50 publications
(12 citation statements)
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“…- 21 In the current study, this membrane phenotype was also associated with a decreased prevalence of hypertension, an association that became even stronger when Platelet membrane fluidity subtype (increased=l, normal=0) was predicted in multiple logistic regression model from risk factors for stroke. Age, cardiac index, and ischemic score were coded as continuous variables.…”
supporting
confidence: 52%
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“…- 21 In the current study, this membrane phenotype was also associated with a decreased prevalence of hypertension, an association that became even stronger when Platelet membrane fluidity subtype (increased=l, normal=0) was predicted in multiple logistic regression model from risk factors for stroke. Age, cardiac index, and ischemic score were coded as continuous variables.…”
supporting
confidence: 52%
“…Our previous reports suggest that this difference arises from an earlier age of onset of cognitive impairment in the former subgroup. 3 -8 ' 21 Furthermore, the patients with increased membrane fluidity were significantly less likely to have a history of hypertension than the normal fluidity subgroup. A history of hypertension remained a significant independent predictor of membrane fluidity classification in a logistic regression analysis that simultaneously controlled for the effects of age and other risk factors for stroke (Table 4).…”
Section: Resultsmentioning
confidence: 95%
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“…There is growing recognition for more than a unitary process in AD and the possibility of subtypes of the disease including early and late onset forms (Filley et al, 1986;Seltzer and Sherwin, 1983) and familial and non-familial forms (St George Hyslop et al, 1987;Zubenko et al, 1988). The earlier study findings of more plaques and tangles in brain tissue of patients with AD were found to be non-specific in subsequent studies that reported the presence of increased numbers of plaques and tangles in brains of older non-demented subjects as well (Blass et al, 1991).…”
Section: Alzheimer's Disease and Related Disordersmentioning
confidence: 99%
“…Zubenko and Teply's [8] explanation of this fact was that increased PMF represents a sub-type of the dis order with a more rapidly progressive course. Zubenko et al [10] showed that the number of relatives with dementia was the same in patients with or without increased PMF but the age of onset of the disorder in affected relatives was earlier in the group with the abnor mality. Eagger et al [II] found that increased PMF was not a marker for familial AD and found a correlation between cognitive function and degree of fluidity in patients without a family history.…”
Section: Introductionmentioning
confidence: 98%