Familial Risk of Pancreatic Cancer

Abstract

Routine questioning of patients about a family history of pancreatic cancer, the age of onset of this cancer in their relatives, and the patient's smoking status may identify individuals at high risk of pancreatic cancer. Future research exploring the genetic and environmental interactions associated with the risk of pancreatic cancer is critically important.

Risk of Other Cancers in Individuals with a Family History of Pancreas Cancer

“…Familial aggregation of pancreas cancer has been reported in various populations [8][9][10][11] , including the families in this current study 12 . Familial clustering of pancreas or other cancers may be influenced by shared environmental factors and by shared genes.…”

Clinical, Laboratory Biomarkers and Imaging Findings of Pancreatic Adenocarcinoma in Iran

“…Another factor, cigarette smoking has proven epidemiological correlation with development of pancreatic cancer (Momi et al, 2012). Other factors include positive family history (Schenk et al, 2001) and type 2 diabetes mellitus (Huxley et al, 2005). Pancreatic cancer symptoms are vague and unknown, this is a reason for that diagnosed in the final stages.…”

Incidence and Trends of Malignant and Benign Pancreatic Lesions in Yazd, Iran between 2001 and 2011

“…Another contributing factor, cigarette smoking has proven epidemiological correlation with development of pancreatic cancer (Momi (Schenk et al, 2001), type 2 diabetes mellitus, (Huxley et al, 2005) and an abundance of single genetic mutations, genetic loci, and hereditary syndromes (Iacobuzio-Donahue, 2012;Klein, 2012;McWilliams et al, 2011). Hereditary conditions including among others familial breast cancer with BRCA2 mutation (Lucas et al, 2013), Peutz-Jeghers syndrome (van Lier et al, 2010), and Hereditary Nonpolyposis Colorectal Cancer (HNCC) (Holmes and Bordeianou, 2011) have been causally implicated in malignant tumors of the pancreas.…”