Familial severe psychiatric history in bipolar disorder and correlation with disease severity and treatment response

Köhler‐Forsberg, Ole; Sylvia, Louisa G.; Ruberto, Valerie L.; Kuperberg, Maya; Shannon, Alec P.; Fung, Vicki; Overhage, Lindsay; Calabrese, Joseph R.; Thase, Michael E.; Bowden, Charles L.; Shelton, Richard C.; McInnis, Melvin G.; Deckersbach, Thilo; Tohen, Mauricio; Kocsis, James H.; Ketter, Terence A.; Friedman, Edward S.; Iosifescu, Dan V.; McElroy, Susan L.; Ostacher, Michael J.; Nierenberg, Andrew A.

doi:10.1016/j.jad.2020.03.157

Cited by 8 publications

(13 citation statements)

References 25 publications

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“…Stage 4 consists of persistent and unremitting symptoms of an episode. Kapczinski et al 2 was not applicable to our study.…”

Section: Introductionmentioning

confidence: 68%

“…It has been widely established that familial loading, especially with parental early‐onset bipolar disorder, is one of the most consistent risk factors for developing BD, 1 but its influence on course and outcome is still understudied. Kohler‐Forsberg 2 found that a family history of BD correlates with an earlier onset and a more severe course and outcome, including more hospitalizations, suicide attempts, and with sociodemographic markers such as lower education and lower household income.…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…The clinical manifestation and course of bipolar disorder (BD) may be influenced by several patient characteristics. In earlier studies, familial loading, 1,2 childhood abuse, 3–5 age at onset, 6–10 illness duration, 11 comorbid psychiatric disorders, 9,12 addiction, 13,14 treatment resistance, 15–18 and cognitive functioning 19–21 have all been hypothesized to be associated with a higher likelihood of developing BD or a worse outcome. These factors appear to be interrelated in various ways; for example, an earlier onset of BD is associated with an increased rate of substance use disorders 22 .…”

Section: Introductionmentioning

confidence: 99%

“…Stage 4 consists of persistent and unremitting symptoms of an episode. Kapczinski et al 2 (Model B in this study) employs an alternative staging model based on inter‐episodic functional impairment. This model includes a latent stage and four clinical stages, defined as well defined periods of euthymia without overt psychiatric symptoms (stage I); inter‐episodic symptoms (stage II); marked inter‐episodic impairment in cognition and functioning with inability to work (stage III); and the inability to live autonomously owing to cognitive and functional impairment (stage IV).…”

Section: Introductionmentioning

confidence: 99%

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Clinical profiles of subsequent stages in bipolar disorder: Results from the Dutch Bipolar Cohort

et al. 2021

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Introduction The manifestation of bipolar disorder (BD) is hypothesized to be determined by clinical characteristics such as familial loading, childhood abuse, age at onset, illness duration, comorbid psychiatric disorders, addiction, treatment resistance, and premorbid cognitive functioning. Which of these are associated with a more severe course and worse outcome is currently unknown. Our objective is to find a combination of clinical characteristics associated with advancement to subsequent stages in two clinical staging models for BD. Methods Using cross‐sectional data from the Dutch Bipolar Cohort, staging was applied to determine the progression of bipolar‐I‐disorder (BD‐I; N = 1396). Model A is primarily defined by recurrence of mood episodes, ranging from prodromal to chronicity. Model B is defined by level of inter‐episodic functioning, ranging from prodromal to inability to function autonomously. For both models, ordinal logistic regression was conducted to test which clinical characteristics are associated with subsequent stages. Results For model A, familial loading, childhood abuse, earlier onset, longer illness duration, psychiatric comorbidity, and treatment resistance were all predictors for a higher stage in contrast to addiction and cognitive functioning. For model B, childhood abuse, psychiatric comorbidity, cognitive functioning, and treatment resistance were predictors for a more severe stage, whereas age at onset, illness duration, and addiction were not. Discussion/conclusions Differences in clinical characteristics across stages support the construct validity of both staging models. Characteristics associated with a higher stage largely overlapped across both models. This study is a first step toward determining different clinical profiles, with a corresponding course and outcome.

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“…Stage 4 consists of persistent and unremitting symptoms of an episode. Kapczinski et al 2 was not applicable to our study.…”

Section: Introductionmentioning

confidence: 68%

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical profiles of subsequent stages in bipolar disorder: Results from the Dutch Bipolar Cohort

et al. 2021

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“…In relation with severity of BD, a lack of objectivity exists in the current diagnostic system to differentiate more severe patients. Some studies define severity of illness course as early onset of BD [ 11 ]; other authors consider illness severity of BD as having anxiety symptoms [ 12 , 13 ], or correlation with familial psychiatric history: in most cases, with a first-degree relative with severe mental disorder [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Social cognition in first-degree relatives of bipolar disorder: Theory of Mind and nonverbal sensitivity

et al. 2021

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Social cognition might be impaired in first degree relatives (FDR) of BD but existing research shows controversial results about social cognitive impairments in this population. The aim of this study was to assess Theory of Mind (ToM) and nonverbal sensitivity in FDR of BD and compare the results with those of two groups of persons with remitted bipolar disorder (BD), type I and II, and a control group. Social cognitive ability was examined in first degree relatives of BD, with a biological parent, offspring or sibling diagnosed with the disorder. For this study, 37 FDRs of bipolar patients, 37 BD I, 40 BD II and 40 control participants were recruited. Social cognition was explored by means of the Reading the Mind in the Eyes Test and the MiniPONS. Results showed a significant impairment in FDR of BD in the ToM task, but not in nonverbal sensitivity. Performance of FDRs in social cognition is better than that of BDs (either type I or type II) but worse when compared with that of healthy individuals without a family history of psychiatric disorders. Nevertheless, no differences were found between BD I and BD II groups. Males and older participants showed a worse performance in all groups. Group family therapy with FDRs of BD might include training in the recognition of nonverbal cues, which might increase the understanding of their familiars with BD, in order to modify communication abilities.

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Progress and Implications from Genetic Studies of Bipolar Disorder

Kong,

Chen,

Shen

et al. 2024

Neurosci. Bull.

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Familial severe psychiatric history in bipolar disorder and correlation with disease severity and treatment response

Cited by 8 publications

References 25 publications

Clinical profiles of subsequent stages in bipolar disorder: Results from the Dutch Bipolar Cohort

Clinical profiles of subsequent stages in bipolar disorder: Results from the Dutch Bipolar Cohort

Social cognition in first-degree relatives of bipolar disorder: Theory of Mind and nonverbal sensitivity

Progress and Implications from Genetic Studies of Bipolar Disorder

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